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Senescence of mesenchymal stem cells (Review).
Int J Mol Med 2017; 39(4):775-782IJ

Abstract

Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases, due to their immunomodulatory and inflammatory effects. However, the function of MSCs is known to decline with age, a process that is called senescence. To date, the process of MSC senescence remains unknown as in-depth understanding of the mechanisms involved in cellular senescence is lacking. First, senescent MSCs are so heterogeneous that not all of them express the same phenotypic markers. In addition, the genes and signaling pathways which regulate this process in MSCs are still unknown. Thus, an understanding of the molecular processes controlling MSC senescence is crucial to determining the drivers and effectors of age-associated MSC dysfunction. Moreover, the proper use of MSCs for clinical application requires a general understanding of the MSC aging process. Furthermore, such knowledge is essential for the development of therapeutic interventions that can slow or reverse age-related degenerative changes to enhance repair processes and maintain healthy function in aging tissues. To further clarify the properties of senescent cells, as well as to present significant findings from studies on the mechanisms of cellular aging, we summarize these biological features in the senescence of MSCs in this scenario. This review summarizes recent advances in our understanding of the markers and differentiation potential indicating MSC senescence, as well as factors affecting MSC senescence with particular emphasis on the roles of oxidative stress, intrinsic changes in telomere shortening, histone deacetylase and DNA methyltransferase, genes and signaling pathways and immunological properties.

Authors+Show Affiliations

Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28290609

Citation

Li, Yi, et al. "Senescence of Mesenchymal Stem Cells (Review)." International Journal of Molecular Medicine, vol. 39, no. 4, 2017, pp. 775-782.
Li Y, Wu Q, Wang Y, et al. Senescence of mesenchymal stem cells (Review). Int J Mol Med. 2017;39(4):775-782.
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., & Bao, J. (2017). Senescence of mesenchymal stem cells (Review). International Journal of Molecular Medicine, 39(4), pp. 775-782. doi:10.3892/ijmm.2017.2912.
Li Y, et al. Senescence of Mesenchymal Stem Cells (Review). Int J Mol Med. 2017;39(4):775-782. PubMed PMID: 28290609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Senescence of mesenchymal stem cells (Review). AU - Li,Yi, AU - Wu,Qiong, AU - Wang,Yujia, AU - Li,Li, AU - Bu,Hong, AU - Bao,Ji, Y1 - 2017/03/09/ PY - 2016/02/02/received PY - 2017/01/13/accepted PY - 2017/3/16/pubmed PY - 2017/4/30/medline PY - 2017/3/15/entrez SP - 775 EP - 782 JF - International journal of molecular medicine JO - Int. J. Mol. Med. VL - 39 IS - 4 N2 - Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases, due to their immunomodulatory and inflammatory effects. However, the function of MSCs is known to decline with age, a process that is called senescence. To date, the process of MSC senescence remains unknown as in-depth understanding of the mechanisms involved in cellular senescence is lacking. First, senescent MSCs are so heterogeneous that not all of them express the same phenotypic markers. In addition, the genes and signaling pathways which regulate this process in MSCs are still unknown. Thus, an understanding of the molecular processes controlling MSC senescence is crucial to determining the drivers and effectors of age-associated MSC dysfunction. Moreover, the proper use of MSCs for clinical application requires a general understanding of the MSC aging process. Furthermore, such knowledge is essential for the development of therapeutic interventions that can slow or reverse age-related degenerative changes to enhance repair processes and maintain healthy function in aging tissues. To further clarify the properties of senescent cells, as well as to present significant findings from studies on the mechanisms of cellular aging, we summarize these biological features in the senescence of MSCs in this scenario. This review summarizes recent advances in our understanding of the markers and differentiation potential indicating MSC senescence, as well as factors affecting MSC senescence with particular emphasis on the roles of oxidative stress, intrinsic changes in telomere shortening, histone deacetylase and DNA methyltransferase, genes and signaling pathways and immunological properties. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/28290609/Senescence_of_mesenchymal_stem_cells__Review__ L2 - http://www.spandidos-publications.com/ijmm/39/4/775 DB - PRIME DP - Unbound Medicine ER -