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[Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life].
Turk Psikiyatri Derg. 2017 Spring; 28(1):71-73.TP

Abstract

Autism spectrum disorders (ASD) are neuropsychiatric disorders characterized by impairment in social interactions, in verbal and non-verbal communication, and restricted and stereotyped patterns of interest and behavior within the first 3 years of life. Pharmacologic interventions may be needed for the treatment of temper tantrums, aggression, hyperactivity, and stereotypes in children with ASD. The approval of aripiprazole by the United States Food and Drug Administration (USFDA) for the treatment of temper tantrums in children and adolescents with ASD has gained increased interest for the use in these patients. Aripiprazole is a partial agonist for the dopamine D2, serotonin 5-HT1A receptors, and an antagonist for 5HT2A receptors. Because aripiprazole is a partial agonist, it has been is speculated that aripiprazole has a protective effect for extrapyramidal side effects, movement disorders, and metabolic problems. But the increased use in children and adolescents is associated with an increase in the number of case reports related with such problems. Nevertheless, our review of the literature uncovered limited data regarding the association between acute dystonia and aripiprazole use in ASD children under five years of age is. In this paper, we present two cases of autistic spectrum disorder children with ages under 5 years that developed acute dystonia taking aripiprazole.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

tur

PubMed ID

28291301

Citation

Küçükköse, Mustafa, and Bürge Kabukçu Başay. "[Acute Dystonia Due to Aripiprazole Use in Two Children With Autism Spectrum Disorder in the First Five Years of Life]." Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry, vol. 28, no. 1, 2017, pp. 71-73.
Küçükköse M, Kabukçu Başay B. [Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life]. Turk Psikiyatri Derg. 2017;28(1):71-73.
Küçükköse, M., & Kabukçu Başay, B. (2017). [Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life]. Turk Psikiyatri Dergisi = Turkish Journal of Psychiatry, 28(1), 71-73.
Küçükköse M, Kabukçu Başay B. [Acute Dystonia Due to Aripiprazole Use in Two Children With Autism Spectrum Disorder in the First Five Years of Life]. Turk Psikiyatri Derg. 2017;28(1):71-73. PubMed PMID: 28291301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acute Dystonia due to Aripiprazole Use in Two Children with Autism Spectrum Disorder in the First Five Years of Life]. AU - Küçükköse,Mustafa, AU - Kabukçu Başay,Bürge, PY - 2017/3/15/entrez PY - 2017/3/16/pubmed PY - 2017/8/29/medline SP - 71 EP - 73 JF - Turk psikiyatri dergisi = Turkish journal of psychiatry JO - Turk Psikiyatri Derg VL - 28 IS - 1 N2 - Autism spectrum disorders (ASD) are neuropsychiatric disorders characterized by impairment in social interactions, in verbal and non-verbal communication, and restricted and stereotyped patterns of interest and behavior within the first 3 years of life. Pharmacologic interventions may be needed for the treatment of temper tantrums, aggression, hyperactivity, and stereotypes in children with ASD. The approval of aripiprazole by the United States Food and Drug Administration (USFDA) for the treatment of temper tantrums in children and adolescents with ASD has gained increased interest for the use in these patients. Aripiprazole is a partial agonist for the dopamine D2, serotonin 5-HT1A receptors, and an antagonist for 5HT2A receptors. Because aripiprazole is a partial agonist, it has been is speculated that aripiprazole has a protective effect for extrapyramidal side effects, movement disorders, and metabolic problems. But the increased use in children and adolescents is associated with an increase in the number of case reports related with such problems. Nevertheless, our review of the literature uncovered limited data regarding the association between acute dystonia and aripiprazole use in ASD children under five years of age is. In this paper, we present two cases of autistic spectrum disorder children with ages under 5 years that developed acute dystonia taking aripiprazole. SN - 1300-2163 UR - https://www.unboundmedicine.com/medline/citation/28291301/[Acute_Dystonia_due_to_Aripiprazole_Use_in_Two_Children_with_Autism_Spectrum_Disorder_in_the_First_Five_Years_of_Life]_ L2 - http://www.turkpsikiyatri.com/ftr.aspx?id=1067 DB - PRIME DP - Unbound Medicine ER -