Tags

Type your tag names separated by a space and hit enter

A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men.
Br J Ophthalmol. 2017 10; 101(10):1367-1373.BJ

Abstract

BACKGROUND

Few longitudinal studies have evaluated the relationship between cigarette smoking and risk of neovascular age-related macular degeneration (AMD) among Asian populations. This study aimed to prospectively evaluate the association between cigarette smoking and risk of neovascular AMD among Korean men.

METHODS

Men between the ages of 45 and 79 years included in the Korea National Health Insurance Service database from 2002 through 2013. We compared hazard ratios (HR) for neovascular AMD between 64 560 past/current and 64 560 never smokers by 1:1 propensity-matched analysis and 85 267 past/current and 72 347 never smokers by unmatched cohort and propensity-adjusted analysis.

RESULTS

The risk of neovascular AMD among past/current smokers was 50% higher than that among never smokers (propensity-adjusted whole cohort analysis: HR, 1.48; 95% CI 1.22 to 1.79; propensity-matched analysis: HR, 1.50; 95% CI 1.22 to 1.84), with the risk more pronounced among current than past smokers (current vs past smokers: propensity-adjusted whole cohort analysis, HR, 1.66; 95% CI 1.35 to 2.04 vs HR, 1.15, 95% CI 0.87 to 1.52; propensity-matched analysis, HR, 1.65; 95% CI 1.32 to 2.05 vs HR, 1.21; 95% CI 0.90 to 1.63). Duration of smoking and daily cigarette consumption was associated with the incidence of neovascular AMD in a dose-dependent manner (p<0.001 for trend).

CONCLUSIONS

Cigarette smoking is associated with a strong risk of neovascular AMD among Korean men. These data highlight the public health impact of smoking on blindness in Asia.

Authors+Show Affiliations

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea. Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Gyeonggi-do, Korea.Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.Department of Policy Research Affairs, National Health Insurance Service Ilsan Hospital, Goyang, Gyeonggi-do, Korea.Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea. Yonsei Healthcare Big Data Based Knowledge Integration System Research Center, Yonsei University College of Medicine, Seoul, Korea. Institute of Convergence Science, Yonsei University College of Medicine, Seoul, Korea.Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28292774

Citation

Rim, Tyler Hyungtaek, et al. "A Nationwide Cohort Study of Cigarette Smoking and Risk of Neovascular Age-related Macular Degeneration in East Asian Men." The British Journal of Ophthalmology, vol. 101, no. 10, 2017, pp. 1367-1373.
Rim TH, Cheng CY, Kim DW, et al. A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. Br J Ophthalmol. 2017;101(10):1367-1373.
Rim, T. H., Cheng, C. Y., Kim, D. W., Kim, S. S., & Wong, T. Y. (2017). A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. The British Journal of Ophthalmology, 101(10), 1367-1373. https://doi.org/10.1136/bjophthalmol-2016-309952
Rim TH, et al. A Nationwide Cohort Study of Cigarette Smoking and Risk of Neovascular Age-related Macular Degeneration in East Asian Men. Br J Ophthalmol. 2017;101(10):1367-1373. PubMed PMID: 28292774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide cohort study of cigarette smoking and risk of neovascular age-related macular degeneration in East Asian men. AU - Rim,Tyler Hyungtaek, AU - Cheng,Ching-Yu, AU - Kim,Dong Wook, AU - Kim,Sung Soo, AU - Wong,Tien Y, Y1 - 2017/03/14/ PY - 2016/11/21/received PY - 2017/01/14/revised PY - 2017/02/07/accepted PY - 2017/3/16/pubmed PY - 2017/10/5/medline PY - 2017/3/16/entrez KW - Epidemiology KW - Retina SP - 1367 EP - 1373 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 101 IS - 10 N2 - BACKGROUND: Few longitudinal studies have evaluated the relationship between cigarette smoking and risk of neovascular age-related macular degeneration (AMD) among Asian populations. This study aimed to prospectively evaluate the association between cigarette smoking and risk of neovascular AMD among Korean men. METHODS: Men between the ages of 45 and 79 years included in the Korea National Health Insurance Service database from 2002 through 2013. We compared hazard ratios (HR) for neovascular AMD between 64 560 past/current and 64 560 never smokers by 1:1 propensity-matched analysis and 85 267 past/current and 72 347 never smokers by unmatched cohort and propensity-adjusted analysis. RESULTS: The risk of neovascular AMD among past/current smokers was 50% higher than that among never smokers (propensity-adjusted whole cohort analysis: HR, 1.48; 95% CI 1.22 to 1.79; propensity-matched analysis: HR, 1.50; 95% CI 1.22 to 1.84), with the risk more pronounced among current than past smokers (current vs past smokers: propensity-adjusted whole cohort analysis, HR, 1.66; 95% CI 1.35 to 2.04 vs HR, 1.15, 95% CI 0.87 to 1.52; propensity-matched analysis, HR, 1.65; 95% CI 1.32 to 2.05 vs HR, 1.21; 95% CI 0.90 to 1.63). Duration of smoking and daily cigarette consumption was associated with the incidence of neovascular AMD in a dose-dependent manner (p<0.001 for trend). CONCLUSIONS: Cigarette smoking is associated with a strong risk of neovascular AMD among Korean men. These data highlight the public health impact of smoking on blindness in Asia. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/28292774/A_nationwide_cohort_study_of_cigarette_smoking_and_risk_of_neovascular_age_related_macular_degeneration_in_East_Asian_men_ L2 - https://bjo.bmj.com/lookup/pmidlookup?view=long&amp;pmid=28292774 DB - PRIME DP - Unbound Medicine ER -