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Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas.
World J Gastroenterol. 2017 Feb 28; 23(8):1443-1449.WJ

Abstract

AIM

To explore the association between Helicobacter pylori (H. pylori) infection status, intestinal metaplasia (IM), and colorectal adenomas.

METHODS

We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing, 13C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies.

RESULTS

The prevalence of H. pylori infection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively. H. pylori infection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95%CI: 1.044-1.753, P = 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785, P = 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95%CI: 1.216-2.277, P = 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929, P = 0.059). Stratification based on H. pylori infection stage and IM revealed that IM accompanied by H. pylori infection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95%CI: 1.383-3.216, P = 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757, P = 0.012).

CONCLUSION

H. pylori-related IM is associated with a high risk of colorectal adenomas in Chinese individuals.

Authors+Show Affiliations

Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.Ye Yan, Yi-Na Chen, Qian Zhao, Chao Chen, Yin Jin, Shuang Pan, Department of Gastroenterology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28293091

Citation

Yan, Ye, et al. "Helicobacter Pylori Infection With Intestinal Metaplasia: an Independent Risk Factor for Colorectal Adenomas." World Journal of Gastroenterology, vol. 23, no. 8, 2017, pp. 1443-1449.
Yan Y, Chen YN, Zhao Q, et al. Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas. World J Gastroenterol. 2017;23(8):1443-1449.
Yan, Y., Chen, Y. N., Zhao, Q., Chen, C., Lin, C. J., Jin, Y., Pan, S., & Wu, J. S. (2017). Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas. World Journal of Gastroenterology, 23(8), 1443-1449. https://doi.org/10.3748/wjg.v23.i8.1443
Yan Y, et al. Helicobacter Pylori Infection With Intestinal Metaplasia: an Independent Risk Factor for Colorectal Adenomas. World J Gastroenterol. 2017 Feb 28;23(8):1443-1449. PubMed PMID: 28293091.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori infection with intestinal metaplasia: An independent risk factor for colorectal adenomas. AU - Yan,Ye, AU - Chen,Yi-Na, AU - Zhao,Qian, AU - Chen,Chao, AU - Lin,Chun-Jing, AU - Jin,Yin, AU - Pan,Shuang, AU - Wu,Jian-Sheng, PY - 2016/10/14/received PY - 2016/12/14/revised PY - 2017/01/04/accepted PY - 2017/3/16/entrez PY - 2017/3/16/pubmed PY - 2017/10/27/medline KW - Chinese population KW - Chronic gastritis KW - Colorectal neoplasms KW - Helicobacter pylori KW - Intestinal metaplasia SP - 1443 EP - 1449 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 23 IS - 8 N2 - AIM: To explore the association between Helicobacter pylori (H. pylori) infection status, intestinal metaplasia (IM), and colorectal adenomas. METHODS: We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing, 13C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies. RESULTS: The prevalence of H. pylori infection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively. H. pylori infection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95%CI: 1.044-1.753, P = 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785, P = 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95%CI: 1.216-2.277, P = 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929, P = 0.059). Stratification based on H. pylori infection stage and IM revealed that IM accompanied by H. pylori infection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95%CI: 1.383-3.216, P = 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757, P = 0.012). CONCLUSION: H. pylori-related IM is associated with a high risk of colorectal adenomas in Chinese individuals. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/28293091/Helicobacter_pylori_infection_with_intestinal_metaplasia:_An_independent_risk_factor_for_colorectal_adenomas_ L2 - http://www.wjgnet.com/1007-9327/full/v23/i8/1443.htm DB - PRIME DP - Unbound Medicine ER -