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Regional distribution of Na-K-ATPase specific activity in the large intestine of the rat and man.
Scand J Gastroenterol Suppl. 1987; 139:37-40.SJ

Abstract

Segmental heterogeneity of colonic electrolyte transport has been demonstrated in rat and man. We determined whether this is reflected by regional differences in Na-K-ATPase activity. In rats, Na-K-ATPase specific activity was significantly lower in the caecum than in the proximal colon, distal colon, and rectum. In man, biopsy specimens of macroscopically intact mucosa in 26 subjects showed no difference in Na-K-ATPase specific activity along the colon axis. We conclude that Na-K-ATPase distribution may contribute to electrolyte transport differences between rat caecum and colon but not between colonic segments in either rat or man. In an additional series of 11 patients with proximal intestinal resections colonic Na-K-ATPase specific activity was slightly but significantly higher than in controls, possibly representing an adaptive process.

Authors+Show Affiliations

Medizinische Klinik Innenstadt, University of Munich, FRG.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2829344

Citation

Loeschke, K, et al. "Regional Distribution of Na-K-ATPase Specific Activity in the Large Intestine of the Rat and Man." Scandinavian Journal of Gastroenterology. Supplement, vol. 139, 1987, pp. 37-40.
Loeschke K, Schreiner J, Heldwein W. Regional distribution of Na-K-ATPase specific activity in the large intestine of the rat and man. Scand J Gastroenterol Suppl. 1987;139:37-40.
Loeschke, K., Schreiner, J., & Heldwein, W. (1987). Regional distribution of Na-K-ATPase specific activity in the large intestine of the rat and man. Scandinavian Journal of Gastroenterology. Supplement, 139, 37-40.
Loeschke K, Schreiner J, Heldwein W. Regional Distribution of Na-K-ATPase Specific Activity in the Large Intestine of the Rat and Man. Scand J Gastroenterol Suppl. 1987;139:37-40. PubMed PMID: 2829344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regional distribution of Na-K-ATPase specific activity in the large intestine of the rat and man. AU - Loeschke,K, AU - Schreiner,J, AU - Heldwein,W, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 37 EP - 40 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 139 N2 - Segmental heterogeneity of colonic electrolyte transport has been demonstrated in rat and man. We determined whether this is reflected by regional differences in Na-K-ATPase activity. In rats, Na-K-ATPase specific activity was significantly lower in the caecum than in the proximal colon, distal colon, and rectum. In man, biopsy specimens of macroscopically intact mucosa in 26 subjects showed no difference in Na-K-ATPase specific activity along the colon axis. We conclude that Na-K-ATPase distribution may contribute to electrolyte transport differences between rat caecum and colon but not between colonic segments in either rat or man. In an additional series of 11 patients with proximal intestinal resections colonic Na-K-ATPase specific activity was slightly but significantly higher than in controls, possibly representing an adaptive process. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/2829344/Regional_distribution_of_Na_K_ATPase_specific_activity_in_the_large_intestine_of_the_rat_and_man_ DB - PRIME DP - Unbound Medicine ER -