Tags

Type your tag names separated by a space and hit enter

Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais.
Int J Rheum Dis. 2017 Oct; 20(10):1572-1581.IJ

Abstract

OBJECTIVE

Autoantibody profiles in systemic sclerosis (SSc) and their relative clinical association vary between studies. The rate for being anti-topoisomerase-I (ATA) positive and the association with diffuse cutaneous the SSc subset (dcSSc) is higher among Thais than among Caucasians. The objective was to evaluate the relevance of clinical presentation, namely being positive for one or more autoantibodies among Thai SSc patients.

METHOD

A retrospective, cohort study was performed among SSc patients over 18 years of age at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006 to December 2013. Autoantibodies comprising 13 SSc-specific antigens were evaluated using the EUROIMMUN AG (Lübeck, Germany) in order to define their clinical association(s).

RESULTS

Two hundred and eighty-five scleroderma patients (200 female; 85 male) were included. The majority (66.7%) were dcSSc subset. ATA was the most common antibody profile in our patients (231 cases; 81.1%), followed by anti-Ro 52 (87 cases; 30.5%). Eleven of our patients (3.9%) were negative for all antibody profiles and 44 cases (15.4%) were negative for ATA and anti-centromere antibody (anti-CENP). Almost 40% (112 cases) were positive for at least two autoantibodies. There was an association between the presence of ATA and hand deformity (odds ratio [OR] 3.94; 95% CI 1.12-13.84), anti-CENP and hand deformity (OR 0.20; 95% CI 0.02-0.90), anti-Ku and scleroderma-polymyositis overlap syndrome (OR 6.58; 95% CI 2.16-19.39) and the absence of both ATA and anti-CENP with female sex (OR 2.90; 95% CI 1.12-7.51), limited cutaneous SSc subset (OR 2.70; 95% CI 1.30-5.55) and scleroderma-polymyositis overlap syndrome (OR 2.53; 95% CI 1.04-6.16). Neither ATA nor anti-CENP were associated with the SSc subset.

CONCLUSIONS

ATA and anti-CENP were not helpful in differentiating the SSc subset in Thai SSc patients, albeit they were good for predicting hand function. Coexisting ATA and anti-CENP negativity were associated with less extensive skin tightness and SSc overlap syndrome.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28296274

Citation

Foocharoen, Chingching, et al. "Relevance of Clinical and Autoantibody Profiles in Systemic Sclerosis Among Thais." International Journal of Rheumatic Diseases, vol. 20, no. 10, 2017, pp. 1572-1581.
Foocharoen C, Watcharenwong P, Netwijitpan S, et al. Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais. Int J Rheum Dis. 2017;20(10):1572-1581.
Foocharoen, C., Watcharenwong, P., Netwijitpan, S., Mahakkanukrauh, A., Suwannaroj, S., & Nanagara, R. (2017). Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais. International Journal of Rheumatic Diseases, 20(10), 1572-1581. https://doi.org/10.1111/1756-185X.13060
Foocharoen C, et al. Relevance of Clinical and Autoantibody Profiles in Systemic Sclerosis Among Thais. Int J Rheum Dis. 2017;20(10):1572-1581. PubMed PMID: 28296274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais. AU - Foocharoen,Chingching, AU - Watcharenwong,Piyakarn, AU - Netwijitpan,Sittichai, AU - Mahakkanukrauh,Ajanee, AU - Suwannaroj,Siraphop, AU - Nanagara,Ratanvadee, Y1 - 2017/03/10/ PY - 2017/3/16/pubmed PY - 2018/6/12/medline PY - 2017/3/16/entrez KW - clinical aspects systemic sclerosis KW - epidemiology systemic sclerosis SP - 1572 EP - 1581 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 20 IS - 10 N2 - OBJECTIVE: Autoantibody profiles in systemic sclerosis (SSc) and their relative clinical association vary between studies. The rate for being anti-topoisomerase-I (ATA) positive and the association with diffuse cutaneous the SSc subset (dcSSc) is higher among Thais than among Caucasians. The objective was to evaluate the relevance of clinical presentation, namely being positive for one or more autoantibodies among Thai SSc patients. METHOD: A retrospective, cohort study was performed among SSc patients over 18 years of age at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006 to December 2013. Autoantibodies comprising 13 SSc-specific antigens were evaluated using the EUROIMMUN AG (Lübeck, Germany) in order to define their clinical association(s). RESULTS: Two hundred and eighty-five scleroderma patients (200 female; 85 male) were included. The majority (66.7%) were dcSSc subset. ATA was the most common antibody profile in our patients (231 cases; 81.1%), followed by anti-Ro 52 (87 cases; 30.5%). Eleven of our patients (3.9%) were negative for all antibody profiles and 44 cases (15.4%) were negative for ATA and anti-centromere antibody (anti-CENP). Almost 40% (112 cases) were positive for at least two autoantibodies. There was an association between the presence of ATA and hand deformity (odds ratio [OR] 3.94; 95% CI 1.12-13.84), anti-CENP and hand deformity (OR 0.20; 95% CI 0.02-0.90), anti-Ku and scleroderma-polymyositis overlap syndrome (OR 6.58; 95% CI 2.16-19.39) and the absence of both ATA and anti-CENP with female sex (OR 2.90; 95% CI 1.12-7.51), limited cutaneous SSc subset (OR 2.70; 95% CI 1.30-5.55) and scleroderma-polymyositis overlap syndrome (OR 2.53; 95% CI 1.04-6.16). Neither ATA nor anti-CENP were associated with the SSc subset. CONCLUSIONS: ATA and anti-CENP were not helpful in differentiating the SSc subset in Thai SSc patients, albeit they were good for predicting hand function. Coexisting ATA and anti-CENP negativity were associated with less extensive skin tightness and SSc overlap syndrome. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/28296274/Relevance_of_clinical_and_autoantibody_profiles_in_systemic_sclerosis_among_Thais_ L2 - https://doi.org/10.1111/1756-185X.13060 DB - PRIME DP - Unbound Medicine ER -