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Lung function and impaired kidney function in relation to metabolic syndrome.

Abstract

PURPOSE

This study aimed to assess the relationships between abnormal lung function and indicators of chronic kidney disease in relation to metabolic syndrome (MetS) by using data from the 2011-2013 Korea National Health and Nutrition Examination Survey.

METHODS

Using the data of 8551 Korean adults (3798 men, 4753 women, ≥40 years), lung function categories [obstructive lung disease (OLD), restrictive lung disease (RLD), and non-obstructive/non-restrictive lung disease (reference group)] were defined for each gender. Albuminuria and low estimated glomerular filtration rate (eGFR) were defined as urine albumin-to-creatinine ratio ≥30 mg/g and eGFR < 60 mL/min/1.73 m2. Gender-specific logistic regression analysis was performed after adjusting for age, educational level, smoking, alcohol use, physical activity, and medication use for chronic diseases.

RESULTS

Compared to the reference group, low eGFR was associated with higher odds for RLD in men and RLD or OLD in women when they did not have MetS. In those with MetS, low eGFR was associated with higher odds for OLD in men and RLD or OLD in women. Albuminuria was associated with higher odds for RLD in men who did not have MetS, while it was associated with higher odds for RLD or OLD in men and women who had MetS.

CONCLUSIONS

Abnormal lung function was associated with increased odds for chronic kidney disease indicators, when combined with MetS in both gender. Even in those without MetS, RLD in men was associated with increased odds for low eGFR or albuminuria, while RLD or OLD in women was associated with increased odds for low eGFR.

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  • Authors+Show Affiliations

    Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, 633-165 Gaegum-dong, Busan Jin-Gu, Busan, 614-735, Republic of Korea. fmlky@inje.ac.kr.

    Source

    International urology and nephrology 49:7 2017 Jul pg 1217-1223

    MeSH

    Adult
    Aged
    Albuminuria
    Blood Glucose
    Blood Pressure
    Cholesterol, HDL
    Creatinine
    Cross-Sectional Studies
    Female
    Forced Expiratory Volume
    Glomerular Filtration Rate
    Humans
    Hyperglycemia
    Hypertension
    Lung Diseases, Obstructive
    Male
    Metabolic Syndrome
    Middle Aged
    Nutrition Surveys
    Republic of Korea
    Sex Factors
    Triglycerides
    Vital Capacity
    Waist Circumference

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28299524

    Citation

    Lee, Kayoung. "Lung Function and Impaired Kidney Function in Relation to Metabolic Syndrome." International Urology and Nephrology, vol. 49, no. 7, 2017, pp. 1217-1223.
    Lee K. Lung function and impaired kidney function in relation to metabolic syndrome. Int Urol Nephrol. 2017;49(7):1217-1223.
    Lee, K. (2017). Lung function and impaired kidney function in relation to metabolic syndrome. International Urology and Nephrology, 49(7), pp. 1217-1223. doi:10.1007/s11255-017-1567-1.
    Lee K. Lung Function and Impaired Kidney Function in Relation to Metabolic Syndrome. Int Urol Nephrol. 2017;49(7):1217-1223. PubMed PMID: 28299524.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lung function and impaired kidney function in relation to metabolic syndrome. A1 - Lee,Kayoung, Y1 - 2017/03/15/ PY - 2016/12/04/received PY - 2017/03/08/accepted PY - 2017/3/17/pubmed PY - 2018/6/15/medline PY - 2017/3/17/entrez KW - Albuminuria KW - Estimated glomerular filtration rate KW - Lung function KW - Metabolic syndrome SP - 1217 EP - 1223 JF - International urology and nephrology JO - Int Urol Nephrol VL - 49 IS - 7 N2 - PURPOSE: This study aimed to assess the relationships between abnormal lung function and indicators of chronic kidney disease in relation to metabolic syndrome (MetS) by using data from the 2011-2013 Korea National Health and Nutrition Examination Survey. METHODS: Using the data of 8551 Korean adults (3798 men, 4753 women, ≥40 years), lung function categories [obstructive lung disease (OLD), restrictive lung disease (RLD), and non-obstructive/non-restrictive lung disease (reference group)] were defined for each gender. Albuminuria and low estimated glomerular filtration rate (eGFR) were defined as urine albumin-to-creatinine ratio ≥30 mg/g and eGFR < 60 mL/min/1.73 m2. Gender-specific logistic regression analysis was performed after adjusting for age, educational level, smoking, alcohol use, physical activity, and medication use for chronic diseases. RESULTS: Compared to the reference group, low eGFR was associated with higher odds for RLD in men and RLD or OLD in women when they did not have MetS. In those with MetS, low eGFR was associated with higher odds for OLD in men and RLD or OLD in women. Albuminuria was associated with higher odds for RLD in men who did not have MetS, while it was associated with higher odds for RLD or OLD in men and women who had MetS. CONCLUSIONS: Abnormal lung function was associated with increased odds for chronic kidney disease indicators, when combined with MetS in both gender. Even in those without MetS, RLD in men was associated with increased odds for low eGFR or albuminuria, while RLD or OLD in women was associated with increased odds for low eGFR. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/28299524/Lung_function_and_impaired_kidney_function_in_relation_to_metabolic_syndrome_ L2 - https://doi.org/10.1007/s11255-017-1567-1 DB - PRIME DP - Unbound Medicine ER -