Tags

Type your tag names separated by a space and hit enter

The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats.
Fundam Clin Pharmacol. 2017 Aug; 31(4):438-446.FC

Abstract

Endometrial hyperplasia (EH) is a common gynecological condition and may progress to carcinoma. We investigated the effect of diacerein (DIA) on estradiol benzoate (EB)-induced EH and atypia. DIA (50 mg/kg/day) was administered orally to rats for 4 weeks, in the presence or absence of EH induced by intramuscular injection of EB (60 μg/100 g) three times per week for 4 weeks. We measured levels of serum total cholesterol, uterine tissue malondialdehyde (MDA), total nitrites (NOx), superoxide dismutase (SOD) activity, caspase-3, interleukin-1b (IL-1b) immunoexpressions, and histopathology. Results showed that EB-induced EH and atypia manifested by significant increase in serum total cholesterol with increase in MDA and NOx levels. EB showed the typical histopathological changes of EH and atypia. In addition, there was reduction in SOD activity and decrease in caspase-3 immunoexpressions but increase in IL-1b immunoexpressions. DIA was able to reduce EB-induced pathological changes.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, El-Minia University, 61511, El-Minia, Egypt.Department of Pathology, Faculty of Medicine, El-Minia University, 61511, El-Minia, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28299811

Citation

Refaie, Marwa M M., and Maram El-Hussieny. "The Role of Interleukin-1b and Its Antagonist (diacerein) in Estradiol Benzoate-induced Endometrial Hyperplasia and Atypia in Female Rats." Fundamental & Clinical Pharmacology, vol. 31, no. 4, 2017, pp. 438-446.
Refaie MMM, El-Hussieny M. The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. Fundam Clin Pharmacol. 2017;31(4):438-446.
Refaie, M. M. M., & El-Hussieny, M. (2017). The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. Fundamental & Clinical Pharmacology, 31(4), 438-446. https://doi.org/10.1111/fcp.12285
Refaie MMM, El-Hussieny M. The Role of Interleukin-1b and Its Antagonist (diacerein) in Estradiol Benzoate-induced Endometrial Hyperplasia and Atypia in Female Rats. Fundam Clin Pharmacol. 2017;31(4):438-446. PubMed PMID: 28299811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of interleukin-1b and its antagonist (diacerein) in estradiol benzoate-induced endometrial hyperplasia and atypia in female rats. AU - Refaie,Marwa M M, AU - El-Hussieny,Maram, Y1 - 2017/04/26/ PY - 2016/12/26/received PY - 2017/03/05/revised PY - 2017/03/13/accepted PY - 2017/3/17/pubmed PY - 2018/4/6/medline PY - 2017/3/17/entrez KW - caspase-3 KW - diacerein KW - endometrial hyperplasia KW - estradiol benzoate KW - interleukin-1b SP - 438 EP - 446 JF - Fundamental & clinical pharmacology JO - Fundam Clin Pharmacol VL - 31 IS - 4 N2 - Endometrial hyperplasia (EH) is a common gynecological condition and may progress to carcinoma. We investigated the effect of diacerein (DIA) on estradiol benzoate (EB)-induced EH and atypia. DIA (50 mg/kg/day) was administered orally to rats for 4 weeks, in the presence or absence of EH induced by intramuscular injection of EB (60 μg/100 g) three times per week for 4 weeks. We measured levels of serum total cholesterol, uterine tissue malondialdehyde (MDA), total nitrites (NOx), superoxide dismutase (SOD) activity, caspase-3, interleukin-1b (IL-1b) immunoexpressions, and histopathology. Results showed that EB-induced EH and atypia manifested by significant increase in serum total cholesterol with increase in MDA and NOx levels. EB showed the typical histopathological changes of EH and atypia. In addition, there was reduction in SOD activity and decrease in caspase-3 immunoexpressions but increase in IL-1b immunoexpressions. DIA was able to reduce EB-induced pathological changes. SN - 1472-8206 UR - https://www.unboundmedicine.com/medline/citation/28299811/The_role_of_interleukin_1b_and_its_antagonist__diacerein__in_estradiol_benzoate_induced_endometrial_hyperplasia_and_atypia_in_female_rats_ L2 - https://doi.org/10.1111/fcp.12285 DB - PRIME DP - Unbound Medicine ER -