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Medicinal Plants as Protective Strategies Against Parkinson's Disease.
Curr Pharm Des. 2017; 23(28):4180-4188.CP

Abstract

Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds.

Authors+Show Affiliations

Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.Universidad San Sebastian, Lientur 1457, Concepcion, 4030000. Chile.Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.Institute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya St., 119991 Moscow. Russian Federation.Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam-530 045, Andhra Pradesh. India.GALLY International Biomedical Research Consulting LLC, San Antonio, TX. United States.Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogota D.C. Colombia.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28302024

Citation

Mazo, Natalia Areiza, et al. "Medicinal Plants as Protective Strategies Against Parkinson's Disease." Current Pharmaceutical Design, vol. 23, no. 28, 2017, pp. 4180-4188.
Mazo NA, Echeverria V, Cabezas R, et al. Medicinal Plants as Protective Strategies Against Parkinson's Disease. Curr Pharm Des. 2017;23(28):4180-4188.
Mazo, N. A., Echeverria, V., Cabezas, R., Avila-Rodriguez, M., Tarasov, V. V., Yarla, N. S., Aliev, G., & Barreto, G. E. (2017). Medicinal Plants as Protective Strategies Against Parkinson's Disease. Current Pharmaceutical Design, 23(28), 4180-4188. https://doi.org/10.2174/1381612823666170316142803
Mazo NA, et al. Medicinal Plants as Protective Strategies Against Parkinson's Disease. Curr Pharm Des. 2017;23(28):4180-4188. PubMed PMID: 28302024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medicinal Plants as Protective Strategies Against Parkinson's Disease. AU - Mazo,Natalia Areiza, AU - Echeverria,Valentina, AU - Cabezas,Ricardo, AU - Avila-Rodriguez,Marco, AU - Tarasov,Vadim V, AU - Yarla,Nagendra S, AU - Aliev,Gjumrakch, AU - Barreto,George E, PY - 2016/08/12/received PY - 2016/09/12/revised PY - 2016/10/12/accepted PY - 2017/3/18/pubmed PY - 2018/7/6/medline PY - 2017/3/18/entrez KW - Parkinson's Disease KW - dopaminergic neurons KW - neuroprotective fruits KW - phytochemicals KW - signaling pathways KW - transcription factors SP - 4180 EP - 4188 JF - Current pharmaceutical design JO - Curr Pharm Des VL - 23 IS - 28 N2 - Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra pars compacta region. An important mechanism contributing to its development is oxidative stress, induced by the imbalance between the endogenous antioxidant defenses and free radicals production. Naturally occurring bioactive compounds exhibit high antioxidant capacity that may help reducing oxidative stress and even reverse the damage induced by ROS. Fruits are particularly rich in phytochemicals with antioxidant effect, and their properties against the development of neurodegenerative diseases are of great interest. This review discusses how the fruits bioactive compounds and synthetic analogs have been assessed for their ability to regulate molecular pathways involved in neuronal survival such as MAPK, Nrf2, and NF-κB, thus elucidating the possible therapeutic and neuroprotective actions of these compounds. SN - 1873-4286 UR - https://www.unboundmedicine.com/medline/citation/28302024/Medicinal_Plants_as_Protective_Strategies_Against_Parkinson's_Disease_ DB - PRIME DP - Unbound Medicine ER -