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Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep.
J Appl Physiol (1985). 1987 Dec; 63(6):2201-7.JA

Abstract

To assess the role of intracellular adenosine 3',5'-cyclic monophosphate (cAMP), we tested the effects of dibutyryl cAMP (DBcAMP), an analogue of cAMP, on lung injury induced by pulmonary air embolism in awake sheep with chronic lung lymph fistula. We infused air (1.23 ml/min) in the pulmonary artery for 2 h in untreated control sheep. In DBcAMP-pretreated sheep DBcAMP was infused (1 mg/kg bolus and 0.02 mg.kg-1.min-1 constantly for 5 h); after 1 h from beginning of DBcAMP administration the air infusion was started. After the air infusion, pulmonary arterial pressure (Ppa) and lung lymph flow rate (Qlym) significantly increased in both groups. DBcAMP-pretreated sheep showed significantly lower responses in Qlym (2.7 X base line) compared with untreated control sheep (4.6 X base line); however, Ppa, left atrial pressure, and lung lymph-to-plasma protein concentration ratio were not significantly different between the two groups. Although plasma and lung lymph thromboxane B2 and 6-ketoprostaglandin F1 alpha concentrations increased significantly during the air infusion, DBcAMP-pretreated sheep showed significantly lower responses. Thus DBcAMP infusion attenuated pulmonary microvascular permeability induced by air embolism. We conclude that pulmonary vascular permeability is in part controlled by the intracellular cAMP level.

Authors+Show Affiliations

First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2830215

Citation

Kobayashi, H, et al. "Effects of Dibutyryl cAMP On Pulmonary Air Embolism-induced Lung Injury in Awake Sheep." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 63, no. 6, 1987, pp. 2201-7.
Kobayashi H, Kobayashi T, Fukushima M. Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep. J Appl Physiol (1985). 1987;63(6):2201-7.
Kobayashi, H., Kobayashi, T., & Fukushima, M. (1987). Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep. Journal of Applied Physiology (Bethesda, Md. : 1985), 63(6), 2201-7.
Kobayashi H, Kobayashi T, Fukushima M. Effects of Dibutyryl cAMP On Pulmonary Air Embolism-induced Lung Injury in Awake Sheep. J Appl Physiol (1985). 1987;63(6):2201-7. PubMed PMID: 2830215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dibutyryl cAMP on pulmonary air embolism-induced lung injury in awake sheep. AU - Kobayashi,H, AU - Kobayashi,T, AU - Fukushima,M, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 2201 EP - 7 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 63 IS - 6 N2 - To assess the role of intracellular adenosine 3',5'-cyclic monophosphate (cAMP), we tested the effects of dibutyryl cAMP (DBcAMP), an analogue of cAMP, on lung injury induced by pulmonary air embolism in awake sheep with chronic lung lymph fistula. We infused air (1.23 ml/min) in the pulmonary artery for 2 h in untreated control sheep. In DBcAMP-pretreated sheep DBcAMP was infused (1 mg/kg bolus and 0.02 mg.kg-1.min-1 constantly for 5 h); after 1 h from beginning of DBcAMP administration the air infusion was started. After the air infusion, pulmonary arterial pressure (Ppa) and lung lymph flow rate (Qlym) significantly increased in both groups. DBcAMP-pretreated sheep showed significantly lower responses in Qlym (2.7 X base line) compared with untreated control sheep (4.6 X base line); however, Ppa, left atrial pressure, and lung lymph-to-plasma protein concentration ratio were not significantly different between the two groups. Although plasma and lung lymph thromboxane B2 and 6-ketoprostaglandin F1 alpha concentrations increased significantly during the air infusion, DBcAMP-pretreated sheep showed significantly lower responses. Thus DBcAMP infusion attenuated pulmonary microvascular permeability induced by air embolism. We conclude that pulmonary vascular permeability is in part controlled by the intracellular cAMP level. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/2830215/Effects_of_dibutyryl_cAMP_on_pulmonary_air_embolism_induced_lung_injury_in_awake_sheep_ L2 - https://journals.physiology.org/doi/10.1152/jappl.1987.63.6.2201?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -