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The mechanisms of air pollution and particulate matter in cardiovascular diseases.
Heart Fail Rev. 2017 05; 22(3):337-347.HF

Abstract

Clinical and epidemiological studies demonstrate that short- and long-term exposure to air pollution increases mortality due to respiratory and cardiovascular diseases. Given the increased industrialization and the increased sources of pollutants (i.e., cars exhaust emissions, cigarette smoke, industry emissions, burning of fossil fuels, incineration of garbage), air pollution has become a key public health issue to solve. Among pollutants, the particulate matter (PM) is a mixture of solid and liquid particles which differently affects human health depending on their size (i.e., PM10 with a diameter <10 μm reach the lung and PM2.5 with a diameter <2.5 μm penetrate deeper into the lung). In particular, the acute exposure to PM10 and PM2.5 increases the rate of cardiovascular deaths. Thus, appropriate interventions to reduce air pollution may promote great benefits to public health by reducing the risk of cardiovascular diseases. Several biological mechanisms have been identified to date which could be responsible for PM-dependent adverse cardiovascular outcomes. Indeed, the exposure to PM10 and PM2.5 induces sustained oxidative stress and inflammation. PM2.5 is also able to increase autonomic nervous system activation. Some potential therapeutic approaches have been tested both in pre-clinical and clinical studies, based on the intake of antioxidants from dietary or by pharmacological administration. Studies are still in progress to increase the knowledge of PM activation of intracellular pathways and propose new strategies of intervention.

Authors+Show Affiliations

I.O.S, Southern Italy Hospital Institute, Medicina Futura Research, 80100, Naples, Italy.I.O.S, Southern Italy Hospital Institute, Medicina Futura Research, 80100, Naples, Italy.Department of Advanced Biomedical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy.Division of Cardiac Surgery, AOU San Giovanni di Dio e Ruggi d'Aragona, Via Largo d'Ippocrate, 84131, Salerno, Italy.Division of Cardiac Surgery, AOU San Giovanni di Dio e Ruggi d'Aragona, Via Largo d'Ippocrate, 84131, Salerno, Italy. Department of Medicine and Surgery, University of Salerno, Via Salvator Allende, 84081, Baronissi, SA, Italy.Department of Advanced Biomedical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy. danisor@libero.it.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28303426

Citation

Fiordelisi, Antonella, et al. "The Mechanisms of Air Pollution and Particulate Matter in Cardiovascular Diseases." Heart Failure Reviews, vol. 22, no. 3, 2017, pp. 337-347.
Fiordelisi A, Piscitelli P, Trimarco B, et al. The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Fail Rev. 2017;22(3):337-347.
Fiordelisi, A., Piscitelli, P., Trimarco, B., Coscioni, E., Iaccarino, G., & Sorriento, D. (2017). The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Failure Reviews, 22(3), 337-347. https://doi.org/10.1007/s10741-017-9606-7
Fiordelisi A, et al. The Mechanisms of Air Pollution and Particulate Matter in Cardiovascular Diseases. Heart Fail Rev. 2017;22(3):337-347. PubMed PMID: 28303426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mechanisms of air pollution and particulate matter in cardiovascular diseases. AU - Fiordelisi,Antonella, AU - Piscitelli,Prisco, AU - Trimarco,Bruno, AU - Coscioni,Enrico, AU - Iaccarino,Guido, AU - Sorriento,Daniela, PY - 2017/3/18/pubmed PY - 2018/3/22/medline PY - 2017/3/18/entrez KW - Acute cardiovascular diseases KW - Air pollution KW - Chronic cardiovascular diseases KW - Oxidative stress KW - Particulate matter SP - 337 EP - 347 JF - Heart failure reviews JO - Heart Fail Rev VL - 22 IS - 3 N2 - Clinical and epidemiological studies demonstrate that short- and long-term exposure to air pollution increases mortality due to respiratory and cardiovascular diseases. Given the increased industrialization and the increased sources of pollutants (i.e., cars exhaust emissions, cigarette smoke, industry emissions, burning of fossil fuels, incineration of garbage), air pollution has become a key public health issue to solve. Among pollutants, the particulate matter (PM) is a mixture of solid and liquid particles which differently affects human health depending on their size (i.e., PM10 with a diameter <10 μm reach the lung and PM2.5 with a diameter <2.5 μm penetrate deeper into the lung). In particular, the acute exposure to PM10 and PM2.5 increases the rate of cardiovascular deaths. Thus, appropriate interventions to reduce air pollution may promote great benefits to public health by reducing the risk of cardiovascular diseases. Several biological mechanisms have been identified to date which could be responsible for PM-dependent adverse cardiovascular outcomes. Indeed, the exposure to PM10 and PM2.5 induces sustained oxidative stress and inflammation. PM2.5 is also able to increase autonomic nervous system activation. Some potential therapeutic approaches have been tested both in pre-clinical and clinical studies, based on the intake of antioxidants from dietary or by pharmacological administration. Studies are still in progress to increase the knowledge of PM activation of intracellular pathways and propose new strategies of intervention. SN - 1573-7322 UR - https://www.unboundmedicine.com/medline/citation/28303426/The_mechanisms_of_air_pollution_and_particulate_matter_in_cardiovascular_diseases_ L2 - https://doi.org/10.1007/s10741-017-9606-7 DB - PRIME DP - Unbound Medicine ER -