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Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease.
Chin Med J (Engl). 2017 Mar 20; 130(6):669-677.CM

Abstract

BACKGROUND

The clinical significance of metabolic syndrome (MS) score, MS, and its individual components with respect to risk prediction of coronary artery disease (CAD) remains unclear. The objective of this study was to investigate whether and to what extent MS score, MS, and its individual components were related to the risk of CAD.

METHODS

Among 1191 participants who underwent coronary angiography for the confirmation of suspected myocardial ischemia, 858 were included in this study according to the inclusion criteria from September 2010 to June 2013. MS was diagnosed with the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria. The severity of coronary atherosclerosis was assessed by Gensini score.

RESULTS

The results showed that the age- and sex-adjusted odds ratios (OR s) for CAD were as follows: MS score, 1.327; MS, 2.013; elevated waist circumference, 1.447; reduced high-density lipoprotein cholesterol, 1.654; and elevated fasting glucose, 1.782; all P < 0.05; whereas for elevated triglycerides, 1.324, and elevated blood pressure, 1.342, both P > 0.05. After multivariate adjustment, results showed that only MS and elevated fasting glucose were significantly associated with CAD (OR, 1.628, 95% confidence interval [CI], 1.151-2.305, P = 0.006 for elevated fasting glucose, and OR, 1.631, 95% CI, 1.208-2.203, P = 0.001 for MS). The study showed that only MS score and elevated fasting glucose were significantly associated with Gensini score (standardized coefficient, 0.101, P = 0.031 for elevated fasting glucose and standardized coefficient, 0.103, P = 0.009 for MS score).

CONCLUSIONS

The present study demonstrated that MS score, MS, and its individual components might have different contributions to CAD prevalence and severity. MS and elevated fasting glucose were independent risk factors for the prevalence of angiographic CAD whereas MS score and elevated fasting glucose were significantly associated with the severity of CAD.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.Department of Endocrinology and Metabolism, Shanghai Zhongshan Hospital, Fudan University, Shanghai 200032; Fudan Institute for Metabolic Diseases, Shanghai 200032, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28303849

Citation

Gui, Ming-Hui, et al. "Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components On the Prevalence and Severity of Angiographic Coronary Artery Disease." Chinese Medical Journal, vol. 130, no. 6, 2017, pp. 669-677.
Gui MH, Ling Y, Liu L, et al. Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease. Chin Med J (Engl). 2017;130(6):669-677.
Gui, M. H., Ling, Y., Liu, L., Jiang, J. J., Li, X. Y., & Gao, X. (2017). Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease. Chinese Medical Journal, 130(6), 669-677. https://doi.org/10.4103/0366-6999.201611
Gui MH, et al. Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components On the Prevalence and Severity of Angiographic Coronary Artery Disease. Chin Med J (Engl). 2017 Mar 20;130(6):669-677. PubMed PMID: 28303849.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Metabolic Syndrome Score, Metabolic Syndrome, and Its Individual Components on the Prevalence and Severity of Angiographic Coronary Artery Disease. AU - Gui,Ming-Hui, AU - Ling,Yan, AU - Liu,Lin, AU - Jiang,Jing-Jing, AU - Li,Xiao-Ying, AU - Gao,Xin, PY - 2017/3/18/entrez PY - 2017/3/18/pubmed PY - 2017/5/16/medline SP - 669 EP - 677 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 130 IS - 6 N2 - BACKGROUND: The clinical significance of metabolic syndrome (MS) score, MS, and its individual components with respect to risk prediction of coronary artery disease (CAD) remains unclear. The objective of this study was to investigate whether and to what extent MS score, MS, and its individual components were related to the risk of CAD. METHODS: Among 1191 participants who underwent coronary angiography for the confirmation of suspected myocardial ischemia, 858 were included in this study according to the inclusion criteria from September 2010 to June 2013. MS was diagnosed with the 2005 National Cholesterol Education Program Adult Treatment Panel III criteria. The severity of coronary atherosclerosis was assessed by Gensini score. RESULTS: The results showed that the age- and sex-adjusted odds ratios (OR s) for CAD were as follows: MS score, 1.327; MS, 2.013; elevated waist circumference, 1.447; reduced high-density lipoprotein cholesterol, 1.654; and elevated fasting glucose, 1.782; all P < 0.05; whereas for elevated triglycerides, 1.324, and elevated blood pressure, 1.342, both P > 0.05. After multivariate adjustment, results showed that only MS and elevated fasting glucose were significantly associated with CAD (OR, 1.628, 95% confidence interval [CI], 1.151-2.305, P = 0.006 for elevated fasting glucose, and OR, 1.631, 95% CI, 1.208-2.203, P = 0.001 for MS). The study showed that only MS score and elevated fasting glucose were significantly associated with Gensini score (standardized coefficient, 0.101, P = 0.031 for elevated fasting glucose and standardized coefficient, 0.103, P = 0.009 for MS score). CONCLUSIONS: The present study demonstrated that MS score, MS, and its individual components might have different contributions to CAD prevalence and severity. MS and elevated fasting glucose were independent risk factors for the prevalence of angiographic CAD whereas MS score and elevated fasting glucose were significantly associated with the severity of CAD. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/28303849/Effect_of_Metabolic_Syndrome_Score_Metabolic_Syndrome_and_Its_Individual_Components_on_the_Prevalence_and_Severity_of_Angiographic_Coronary_Artery_Disease_ L2 - https://doi.org/10.4103/0366-6999.201611 DB - PRIME DP - Unbound Medicine ER -