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Galactose-1-P-uridyl transferase activity in patients with congenital and infantile cataract.
Ophthalmic Paediatr Genet 1987; 8(3):187-90OP

Abstract

The activity of red blood cell galactose-1-P-uridyl transferase in 22 patients with congenital and infantile cataract and in 18 age-matched controls was investigated. All control subjects examined showed normal enzymatic levels, while 31.8% of patients with congenital and infantile cataract presented a statistically significant reduced enzymatic activity (mean--2 SD in controls). Twenty-four parents of children with congenital and infantile cataract were also examined. Four parents were affected by congenital cataract and the other 20 showed transparent lenses. The parents were compared with a group of 20 age-matched control subjects examined previously. There was no difference in the average enzymatic activities between the groups. The results suggest that a chronic disorder of galactose metabolism may be involved in the development of congenital and infantile cataract.

Authors+Show Affiliations

Eye Clinic, First School of Medicine, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2830571

Citation

Simonelli, F, et al. "Galactose-1-P-uridyl Transferase Activity in Patients With Congenital and Infantile Cataract." Ophthalmic Paediatrics and Genetics, vol. 8, no. 3, 1987, pp. 187-90.
Simonelli F, Cotticelli L, Russo S, et al. Galactose-1-P-uridyl transferase activity in patients with congenital and infantile cataract. Ophthalmic Paediatr Genet. 1987;8(3):187-90.
Simonelli, F., Cotticelli, L., Russo, S., Di Meo, A., & Rinaldi, E. (1987). Galactose-1-P-uridyl transferase activity in patients with congenital and infantile cataract. Ophthalmic Paediatrics and Genetics, 8(3), pp. 187-90.
Simonelli F, et al. Galactose-1-P-uridyl Transferase Activity in Patients With Congenital and Infantile Cataract. Ophthalmic Paediatr Genet. 1987;8(3):187-90. PubMed PMID: 2830571.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Galactose-1-P-uridyl transferase activity in patients with congenital and infantile cataract. AU - Simonelli,F, AU - Cotticelli,L, AU - Russo,S, AU - Di Meo,A, AU - Rinaldi,E, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 187 EP - 90 JF - Ophthalmic paediatrics and genetics JO - Ophthalmic Paediatr Genet VL - 8 IS - 3 N2 - The activity of red blood cell galactose-1-P-uridyl transferase in 22 patients with congenital and infantile cataract and in 18 age-matched controls was investigated. All control subjects examined showed normal enzymatic levels, while 31.8% of patients with congenital and infantile cataract presented a statistically significant reduced enzymatic activity (mean--2 SD in controls). Twenty-four parents of children with congenital and infantile cataract were also examined. Four parents were affected by congenital cataract and the other 20 showed transparent lenses. The parents were compared with a group of 20 age-matched control subjects examined previously. There was no difference in the average enzymatic activities between the groups. The results suggest that a chronic disorder of galactose metabolism may be involved in the development of congenital and infantile cataract. SN - 0167-6784 UR - https://www.unboundmedicine.com/medline/citation/2830571/Galactose_1_P_uridyl_transferase_activity_in_patients_with_congenital_and_infantile_cataract_ L2 - https://medlineplus.gov/cataract.html DB - PRIME DP - Unbound Medicine ER -