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Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice.
J Pharmacol Exp Ther. 1988 Feb; 244(2):592-8.JP

Abstract

The imidazobenzodiazepine Ro 15-4513 has a high affinity for central benzodiazepine binding sites and has been shown to antagonize certain effects of ethanol. The purpose of the present study was to determine if Ro 15-4513 would attenuate the discriminative stimulus properties of ethanol and the other central nervous system depressants pentobarbital and oxazepam. Different groups of mice were trained to discriminate 1.0 or 1.5 g/kg of ethanol, 20 mg/kg of pentobarbital or 10 mg/kg of oxazepam from saline injections in a two-lever operant task. Stimulus generalization tests were conducted with Ro 15-4513 alone (0.01-20 mg/kg) and in combination with the training drugs. The discriminative stimulus effects of ethanol and oxazepam, but not of pentobarbital, were blocked by Ro 15-4513. When given alone in each of the different drug-training groups, Ro 15-4513 did not produce drug-lever responding but decreased overall response rates in a dose-related fashion. Although the alcohols, barbiturates and benzodiazepines share discriminative stimulus properties under many conditions, the selective blockade of their stimulus effects provides further evidence that their actions may be mediated by different cellular mechanisms. These data also show that Ro 15-4513 may attenuate behavioral effects of ethanol relevant to its abuse.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2831347

Citation

Rees, D C., and R L. Balster. "Attenuation of the Discriminative Stimulus Properties of Ethanol and Oxazepam, but Not of Pentobarbital, By Ro 15-4513 in Mice." The Journal of Pharmacology and Experimental Therapeutics, vol. 244, no. 2, 1988, pp. 592-8.
Rees DC, Balster RL. Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice. J Pharmacol Exp Ther. 1988;244(2):592-8.
Rees, D. C., & Balster, R. L. (1988). Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice. The Journal of Pharmacology and Experimental Therapeutics, 244(2), 592-8.
Rees DC, Balster RL. Attenuation of the Discriminative Stimulus Properties of Ethanol and Oxazepam, but Not of Pentobarbital, By Ro 15-4513 in Mice. J Pharmacol Exp Ther. 1988;244(2):592-8. PubMed PMID: 2831347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice. AU - Rees,D C, AU - Balster,R L, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 592 EP - 8 JF - The Journal of pharmacology and experimental therapeutics JO - J. Pharmacol. Exp. Ther. VL - 244 IS - 2 N2 - The imidazobenzodiazepine Ro 15-4513 has a high affinity for central benzodiazepine binding sites and has been shown to antagonize certain effects of ethanol. The purpose of the present study was to determine if Ro 15-4513 would attenuate the discriminative stimulus properties of ethanol and the other central nervous system depressants pentobarbital and oxazepam. Different groups of mice were trained to discriminate 1.0 or 1.5 g/kg of ethanol, 20 mg/kg of pentobarbital or 10 mg/kg of oxazepam from saline injections in a two-lever operant task. Stimulus generalization tests were conducted with Ro 15-4513 alone (0.01-20 mg/kg) and in combination with the training drugs. The discriminative stimulus effects of ethanol and oxazepam, but not of pentobarbital, were blocked by Ro 15-4513. When given alone in each of the different drug-training groups, Ro 15-4513 did not produce drug-lever responding but decreased overall response rates in a dose-related fashion. Although the alcohols, barbiturates and benzodiazepines share discriminative stimulus properties under many conditions, the selective blockade of their stimulus effects provides further evidence that their actions may be mediated by different cellular mechanisms. These data also show that Ro 15-4513 may attenuate behavioral effects of ethanol relevant to its abuse. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/2831347/Attenuation_of_the_discriminative_stimulus_properties_of_ethanol_and_oxazepam_but_not_of_pentobarbital_by_Ro_15_4513_in_mice_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2831347 DB - PRIME DP - Unbound Medicine ER -