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Role of σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia.
Adv Exp Med Biol. 2017; 964:213-233.AE

Abstract

The present chapter will review the role of σ1 receptor in learning and memory and neuroprotection , against Alzheimer's type dementia. σ1 Receptor agonists have been tested in a variety of pharmacological and pathological models of learning impairments in rodents these last past 20 years. Their anti-amnesic effects have been explained by the wide-range modulatory role of σ1 receptors on Ca2+ mobilizations, neurotransmitter responses, and particularly glutamate and acetylcholine systems, and neurotrophic factors. Recent observations from genetic and pharmacological studies have shown that σ1 receptor can also be targeted in neurodegenerative diseases, and particularly Alzheimer's disease . Several compounds, acting partly through the σ1 receptor, have showed effective neuroprotection in transgenic mouse models of Alzheimer's disease . We will review the data and discuss the possible mechanisms of action, particularly focusing on oxidative stress and mitochondrial integrity, trophic factors and a novel hypothesis suggesting a functional interaction between the σ1 receptor and α7 nicotinic acetylcholine receptor. Finally, we will discuss the pharmacological peculiarities of non-selective σ1 receptor ligands, now developed as neuroprotectants in Alzheimer's disease , and positive modulators, recently described and that showed efficacy against learning and memory deficits.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Maurice T
INSERM U1198, University of Montpellier, 34095, Montpellier, France. tangui.maurice@umontpellier.fr.
Goguadze N
INSERM U1198, University of Montpellier, 34095, Montpellier, France. Institute of Chemical Biology, Ilia State University, Tbilisi, 0162, GA, USA.

MeSH

Alzheimer DiseaseAnimalsDementiaHumansLearningLigandsMemoryMemory DisordersNeuroprotective AgentsReceptors, sigmaalpha7 Nicotinic Acetylcholine Receptor

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28315274

Citation

Maurice, Tangui, and Nino Goguadze. "Role of Σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia." Advances in Experimental Medicine and Biology, vol. 964, 2017, pp. 213-233.
Maurice T, Goguadze N. Role of σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia. Adv Exp Med Biol. 2017;964:213-233.
Maurice, T., & Goguadze, N. (2017). Role of σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia. Advances in Experimental Medicine and Biology, 964, 213-233. https://doi.org/10.1007/978-3-319-50174-1_15
Maurice T, Goguadze N. Role of Σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia. Adv Exp Med Biol. 2017;964:213-233. PubMed PMID: 28315274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia. AU - Maurice,Tangui, AU - Goguadze,Nino, PY - 2017/3/19/entrez PY - 2017/3/21/pubmed PY - 2017/9/28/medline KW - Alzheimer’s disease KW - Learning and memory KW - Neuroprotection KW - Oxidative stress KW - Positive allosteric modulators KW - Sigma-1 receptor SP - 213 EP - 233 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 964 N2 - The present chapter will review the role of σ1 receptor in learning and memory and neuroprotection , against Alzheimer's type dementia. σ1 Receptor agonists have been tested in a variety of pharmacological and pathological models of learning impairments in rodents these last past 20 years. Their anti-amnesic effects have been explained by the wide-range modulatory role of σ1 receptors on Ca2+ mobilizations, neurotransmitter responses, and particularly glutamate and acetylcholine systems, and neurotrophic factors. Recent observations from genetic and pharmacological studies have shown that σ1 receptor can also be targeted in neurodegenerative diseases, and particularly Alzheimer's disease . Several compounds, acting partly through the σ1 receptor, have showed effective neuroprotection in transgenic mouse models of Alzheimer's disease . We will review the data and discuss the possible mechanisms of action, particularly focusing on oxidative stress and mitochondrial integrity, trophic factors and a novel hypothesis suggesting a functional interaction between the σ1 receptor and α7 nicotinic acetylcholine receptor. Finally, we will discuss the pharmacological peculiarities of non-selective σ1 receptor ligands, now developed as neuroprotectants in Alzheimer's disease , and positive modulators, recently described and that showed efficacy against learning and memory deficits. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/28315274/Role_of_σ1_Receptors_in_Learning_and_Memory_and_Alzheimer's_Disease_Type_Dementia_ L2 - https://dx.doi.org/10.1007/978-3-319-50174-1_15 DB - PRIME DP - Unbound Medicine ER -