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The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma.
Adv Exp Med Biol. 2017; 964:299-307.AE

Abstract

The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer's and Parkinson's disease . S1R modulates multiple cellular functions associated with neurodegeneration . These include Ca[2+] ion homeostasis, endoplasmic reticulum (ER) and oxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Mysona B
Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Kansara N
Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. The James and Jean Culver Vision Discovery Institute, Augusta, GA, 30912, USA.
Zhao J
The James and Jean Culver Vision Discovery Institute, Augusta, GA, 30912, USA. Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.
Bollinger K
Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. kbollinger@augusta.edu. The James and Jean Culver Vision Discovery Institute, Augusta, GA, 30912, USA. kbollinger@augusta.edu. Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA. kbollinger@augusta.edu. Department of Cellular Biology and Anatomy, Augusta University, Augusta, GA, 30912, USA. kbollinger@augusta.edu.

MeSH

AnimalsEndoplasmic ReticulumGlaucomaHumansNeurodegenerative DiseasesNeuroprotectionNeuroprotective AgentsReceptors, sigmaSignal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28315279

Citation

Mysona, Barbara, et al. "The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma." Advances in Experimental Medicine and Biology, vol. 964, 2017, pp. 299-307.
Mysona B, Kansara N, Zhao J, et al. The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma. Adv Exp Med Biol. 2017;964:299-307.
Mysona, B., Kansara, N., Zhao, J., & Bollinger, K. (2017). The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma. Advances in Experimental Medicine and Biology, 964, 299-307. https://doi.org/10.1007/978-3-319-50174-1_20
Mysona B, et al. The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma. Adv Exp Med Biol. 2017;964:299-307. PubMed PMID: 28315279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Sigma 1 Receptor as a Neuroprotective Target in Glaucoma. AU - Mysona,Barbara, AU - Kansara,Neil, AU - Zhao,Jing, AU - Bollinger,Kathryn, PY - 2017/3/19/entrez PY - 2017/3/21/pubmed PY - 2017/9/28/medline KW - Glaucoma KW - Neurodegeneration KW - Neuroprotection KW - Optic nerve KW - Retinal ganglion cell SP - 299 EP - 307 JF - Advances in experimental medicine and biology JO - Adv Exp Med Biol VL - 964 N2 - The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer's and Parkinson's disease . S1R modulates multiple cellular functions associated with neurodegeneration . These include Ca[2+] ion homeostasis, endoplasmic reticulum (ER) and oxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth. Recent studies using agonists for S1R within the eye provide hope that it could be a therapeutic target for glaucoma. Understanding the role of S1R in glaucoma may help us to stop the progression of this sight threatening disease. SN - 0065-2598 UR - https://www.unboundmedicine.com/medline/citation/28315279/The_Role_of_Sigma_1_Receptor_as_a_Neuroprotective_Target_in_Glaucoma_ DB - PRIME DP - Unbound Medicine ER -