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Characteristics and management of mirror syndrome: a systematic review (1956-2016).
J Perinat Med 2017; 45(9):1013-1021JP

Abstract

OBJECTIVES

To describe the clinical features of mirror syndrome and to correlate the effects of different treatments with the fetal outcomes.

DATA SOURCES

Online search up to May 2016 was conducted in the PubMed, Embase (Ovid platform) and clinicalTrials.gov without restrictions of language, date or journal. Only papers providing both fetal and maternal presentations and outcomes were included.

RESULTS

The study included 74 papers (n=111), with an additional two patients diagnosed at our center (n=113). The mean gestational age at diagnosis was 27 weeks±30 days (16-39 weeks). Whether early or late gestational age at diagnosis, and whether mother and fetus show symptoms simultaneously or on different dates, has insignificant impact on fetal outcome (P=0.06 and P=0.46, respectively). Edema (84%) followed by hypertension (60.1%) were the leading maternal findings. Fetal hydrops (94.7%) and placental edema (62.8%) were the commonest sonographic features. Procedures correcting fetal hydrops/anemia in utero as well as labor induction were the only treatment options correlated with improved fetal survival (χ2 analysis, P=0.01 and Fisher's exact test, P=0.02; respectively). The overall rate of fetal/neonatal mortality was 67.26%.

CONCLUSION

The gestational age at diagnosis and sequence of presentation have insignificant impact on fetal outcome. Improved fetal survival was associated with procedural interventions that correct fetal hydrops as well as labor induction.

Pub Type(s)

Case Reports
Journal Article
Review
Systematic Review

Language

eng

PubMed ID

28315852

Citation

Allarakia, Sabah, et al. "Characteristics and Management of Mirror Syndrome: a Systematic Review (1956-2016)." Journal of Perinatal Medicine, vol. 45, no. 9, 2017, pp. 1013-1021.
Allarakia S, Khayat HA, Karami MM, et al. Characteristics and management of mirror syndrome: a systematic review (1956-2016). J Perinat Med. 2017;45(9):1013-1021.
Allarakia, S., Khayat, H. A., Karami, M. M., Aldakhil, A. M., Kashi, A. M., Algain, A. H., ... Alsulami, R. E. (2017). Characteristics and management of mirror syndrome: a systematic review (1956-2016). Journal of Perinatal Medicine, 45(9), pp. 1013-1021. doi:10.1515/jpm-2016-0422.
Allarakia S, et al. Characteristics and Management of Mirror Syndrome: a Systematic Review (1956-2016). J Perinat Med. 2017 Dec 20;45(9):1013-1021. PubMed PMID: 28315852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics and management of mirror syndrome: a systematic review (1956-2016). AU - Allarakia,Sabah, AU - Khayat,Hassan A, AU - Karami,Moyassar M, AU - Aldakhil,Abdulaziz M, AU - Kashi,Ahmed M, AU - Algain,Abdulrahman H, AU - Khan,Mohammad A, AU - Alghifees,Loai S, AU - Alsulami,Raed E, PY - 2016/12/27/received PY - 2017/01/17/accepted PY - 2017/3/21/pubmed PY - 2018/7/20/medline PY - 2017/3/20/entrez KW - Acute second trimester gestosis KW - ballantyne syndrome KW - fetal hydrops KW - fetal survival KW - maternal edema KW - maternal hydrops syndrome KW - maternal recovery KW - mirror syndrome KW - placental hydrops KW - pseudotoxemia KW - triple edema SP - 1013 EP - 1021 JF - Journal of perinatal medicine JO - J Perinat Med VL - 45 IS - 9 N2 - OBJECTIVES: To describe the clinical features of mirror syndrome and to correlate the effects of different treatments with the fetal outcomes. DATA SOURCES: Online search up to May 2016 was conducted in the PubMed, Embase (Ovid platform) and clinicalTrials.gov without restrictions of language, date or journal. Only papers providing both fetal and maternal presentations and outcomes were included. RESULTS: The study included 74 papers (n=111), with an additional two patients diagnosed at our center (n=113). The mean gestational age at diagnosis was 27 weeks±30 days (16-39 weeks). Whether early or late gestational age at diagnosis, and whether mother and fetus show symptoms simultaneously or on different dates, has insignificant impact on fetal outcome (P=0.06 and P=0.46, respectively). Edema (84%) followed by hypertension (60.1%) were the leading maternal findings. Fetal hydrops (94.7%) and placental edema (62.8%) were the commonest sonographic features. Procedures correcting fetal hydrops/anemia in utero as well as labor induction were the only treatment options correlated with improved fetal survival (χ2 analysis, P=0.01 and Fisher's exact test, P=0.02; respectively). The overall rate of fetal/neonatal mortality was 67.26%. CONCLUSION: The gestational age at diagnosis and sequence of presentation have insignificant impact on fetal outcome. Improved fetal survival was associated with procedural interventions that correct fetal hydrops as well as labor induction. SN - 1619-3997 UR - https://www.unboundmedicine.com/medline/citation/28315852/Characteristics_and_management_of_mirror_syndrome:_a_systematic_review_(1956-2016) L2 - https://www.degruyter.com/doi/10.1515/jpm-2016-0422 DB - PRIME DP - Unbound Medicine ER -