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Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration.
Cell Physiol Biochem. 2017; 41(4):1413-1423.CP

Abstract

Backgroud: Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness of the elder people. This research was intended to demonstrate the different expression of microRNAs (miRNA) in AMD patients and whether they can be used as biomarkers for AMD.

METHODS

MiRNAs expression was measured by microarray of 6 AMD cases and 6 gender matched controls. In a larger-sample case-control study with 126 AMD cases and 140 controls, whole blood samples were detected for the differences of miRNA expression.

RESULTS

A total of 216 differentially expressed miRNAs (111 increased and 105 decreased miRNAs) were detected from circulating miRNA microarray. Expanded case-control study results showed that the expression of miR-27a-3p, miR-29b-3p and miR-195-5p was increased significantly. Moreover, the level of miR-27a is higher in patients with wet AMD compared to patients with dry AMD. All 3 miRNAs showed a potential diagnostic value for AMD.

CONCLUSION

Circulating miRNA levels were significantly varied in AMD patients. Three miRNAs, miR-27a-3p, miR-29b-3p and the miR-195-5p, might be potential diagnostic biomarkers for AMD.

Links

Publisher Full Text
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Authors+Show Affiliations

Ren C
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.
Liu Q
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.
Wei Q
Department of Ophthalmology, Shanghai Tenth people's hospital, Nanchang University, Nanchang, China.
Cai W
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.
He M
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.
Du Y
Department of Ophthalmology, Shanghai Tenth People's hospital, Department of First Clinical Medical College, Nanjing Medical University, Nanjing, China.
Xu D
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.
Wu Y
Department of Ophthalmology, First Affiliated Hospital of Soochow University, Suzhou, China.
Yu J
Department of Ophthalmology, Shanghai Tenth people's hospital, Tongji University School of Medicine, Shanghai, China.

MeSH

AgedBiomarkersFemaleHumansMacular DegenerationMaleMicroRNAsMiddle Aged

Pub Type(s)

Clinical Trial
Journal Article
Validation Study

Language

eng

PubMed ID

28315863

Citation

Ren, Chengda, et al. "Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration." Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, vol. 41, no. 4, 2017, pp. 1413-1423.
Ren C, Liu Q, Wei Q, et al. Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration. Cell Physiol Biochem. 2017;41(4):1413-1423.
Ren, C., Liu, Q., Wei, Q., Cai, W., He, M., Du, Y., Xu, D., Wu, Y., & Yu, J. (2017). Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology, 41(4), 1413-1423. https://doi.org/10.1159/000467941
Ren C, et al. Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration. Cell Physiol Biochem. 2017;41(4):1413-1423. PubMed PMID: 28315863.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating miRNAs as Potential Biomarkers of Age-Related Macular Degeneration. AU - Ren,Chengda, AU - Liu,Qingyu, AU - Wei,Qingquan, AU - Cai,Wenting, AU - He,Mengmei, AU - Du,Yaru, AU - Xu,Ding, AU - Wu,Yan, AU - Yu,Jing, Y1 - 2017/03/16/ PY - 2016/08/30/received PY - 2017/01/26/accepted PY - 2017/3/21/pubmed PY - 2017/6/22/medline PY - 2017/3/20/entrez KW - Age-related macular degeneration KW - Case-control KW - Diagnosis KW - Microarray KW - microRNA SP - 1413 EP - 1423 JF - Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology JO - Cell Physiol Biochem VL - 41 IS - 4 N2 - : Backgroud: Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness of the elder people. This research was intended to demonstrate the different expression of microRNAs (miRNA) in AMD patients and whether they can be used as biomarkers for AMD. METHODS: MiRNAs expression was measured by microarray of 6 AMD cases and 6 gender matched controls. In a larger-sample case-control study with 126 AMD cases and 140 controls, whole blood samples were detected for the differences of miRNA expression. RESULTS: A total of 216 differentially expressed miRNAs (111 increased and 105 decreased miRNAs) were detected from circulating miRNA microarray. Expanded case-control study results showed that the expression of miR-27a-3p, miR-29b-3p and miR-195-5p was increased significantly. Moreover, the level of miR-27a is higher in patients with wet AMD compared to patients with dry AMD. All 3 miRNAs showed a potential diagnostic value for AMD. CONCLUSION: Circulating miRNA levels were significantly varied in AMD patients. Three miRNAs, miR-27a-3p, miR-29b-3p and the miR-195-5p, might be potential diagnostic biomarkers for AMD. SN - 1421-9778 UR - https://www.unboundmedicine.com/medline/citation/28315863/Circulating_miRNAs_as_Potential_Biomarkers_of_Age_Related_Macular_Degeneration_ L2 - https://www.karger.com?DOI=10.1159/000467941 DB - PRIME DP - Unbound Medicine ER -