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The neuroprotective effects of caffeine in neurodegenerative diseases.
CNS Neurosci Ther. 2017 Apr; 23(4):272-290.CN

Abstract

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A2A R antagonism. A study found caffeine to be associated with earlier age of onset of Huntington's disease (HD) at intakes >190 mg/d, but studies in animal models have found equivocal results. Caffeine is protective in AD and PD at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effects of caffeine on PD in women. As well, the effects of caffeine in ALS, HD and Machado-Joseph disease need to be further investigated. Caffeine's most salient mechanisms of action relevant to neurodegenerative diseases need to be further explored.

Authors+Show Affiliations

School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada. Muscle Health Research Centre, York University, Toronto, ON, Canada.School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, ON, Canada. Muscle Health Research Centre, York University, Toronto, ON, Canada.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28317317

Citation

Kolahdouzan, Mahshad, and Mazen J. Hamadeh. "The Neuroprotective Effects of Caffeine in Neurodegenerative Diseases." CNS Neuroscience & Therapeutics, vol. 23, no. 4, 2017, pp. 272-290.
Kolahdouzan M, Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neurosci Ther. 2017;23(4):272-290.
Kolahdouzan, M., & Hamadeh, M. J. (2017). The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neuroscience & Therapeutics, 23(4), 272-290. https://doi.org/10.1111/cns.12684
Kolahdouzan M, Hamadeh MJ. The Neuroprotective Effects of Caffeine in Neurodegenerative Diseases. CNS Neurosci Ther. 2017;23(4):272-290. PubMed PMID: 28317317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuroprotective effects of caffeine in neurodegenerative diseases. AU - Kolahdouzan,Mahshad, AU - Hamadeh,Mazen J, PY - 2016/11/10/received PY - 2017/02/05/revised PY - 2017/02/07/accepted PY - 2017/3/21/entrez PY - 2017/3/21/pubmed PY - 2017/10/19/medline KW - Alzheimer disease KW - Huntington disease KW - Parkinson disease KW - adenosine receptor KW - amyotrophic lateral sclerosis KW - caffeine KW - dosage KW - neurodegenerative disease KW - neuroprotection SP - 272 EP - 290 JF - CNS neuroscience & therapeutics JO - CNS Neurosci Ther VL - 23 IS - 4 N2 - Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A2A R antagonism. A study found caffeine to be associated with earlier age of onset of Huntington's disease (HD) at intakes >190 mg/d, but studies in animal models have found equivocal results. Caffeine is protective in AD and PD at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effects of caffeine on PD in women. As well, the effects of caffeine in ALS, HD and Machado-Joseph disease need to be further investigated. Caffeine's most salient mechanisms of action relevant to neurodegenerative diseases need to be further explored. SN - 1755-5949 UR - https://www.unboundmedicine.com/medline/citation/28317317/The_neuroprotective_effects_of_caffeine_in_neurodegenerative_diseases_ L2 - https://doi.org/10.1111/cns.12684 DB - PRIME DP - Unbound Medicine ER -