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Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice.
J Sleep Res. 2017 06; 26(3):386-393.JS

Abstract

Natural helicid (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. In the current study, mechanical allodynia tests, electroencephalograms, electromyogram recordings and c-Fos expression in neuropathic pain-like model mice of partial sciatic nerve ligation were used to investigate the effect of helicid on neuropathic pain and co-morbid insomnia. Our results showed that helicid at a dose of 100, 200 or 400 mg kg-1 could increase the mechanical threshold by 2.5-, 2.8- and 3.1-fold for 3 h after administration, respectively. Helicid at 200 and 400 mg kg-1 given at 07:00 hours increased the amount of non-rapid eye movement sleep in a 3-h period by 1.27- and 1.35-fold in partial sciatic nerve ligated mice. However, helicid (400 mg kg-1) given at 21:00 hours did not change the sleep pattern in normal mice. Immunohistochemical study showed that helicid (400 mg kg-1) administration could reverse the increase of c-Fos expression in the neurons of the rostral anterior cingulate cortex and tuberomammillary nucleus, and the decrease of c-Fos expression in the ventrolateral preoptic area caused by partial sciatic nerve ligation. These results indicate that helicid is an effective agent for both neuropathic pain and sleep disturbances in partial sciatic nerve ligated mice.

Authors+Show Affiliations

Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, Kunming, China.Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, Kunming, China.Department of Pharmacology and Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28318068

Citation

Zhang, Meng-Qi, et al. "Helicid Alleviates Pain and Sleep Disturbances in a Neuropathic Pain-like Model in Mice." Journal of Sleep Research, vol. 26, no. 3, 2017, pp. 386-393.
Zhang MQ, Wang TX, Li R, et al. Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice. J Sleep Res. 2017;26(3):386-393.
Zhang, M. Q., Wang, T. X., Li, R., Huang, Z. L., Han, W. J., Dai, X. C., & Wang, Y. Q. (2017). Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice. Journal of Sleep Research, 26(3), 386-393. https://doi.org/10.1111/jsr.12518
Zhang MQ, et al. Helicid Alleviates Pain and Sleep Disturbances in a Neuropathic Pain-like Model in Mice. J Sleep Res. 2017;26(3):386-393. PubMed PMID: 28318068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicid alleviates pain and sleep disturbances in a neuropathic pain-like model in mice. AU - Zhang,Meng-Qi, AU - Wang,Tian-Xiao, AU - Li,Rui, AU - Huang,Zhi-Li, AU - Han,Wu-Jian, AU - Dai,Xiao-Chang, AU - Wang,Yi-Qun, Y1 - 2017/03/20/ PY - 2016/11/22/received PY - 2017/02/01/accepted PY - 2017/3/21/pubmed PY - 2017/11/11/medline PY - 2017/3/21/entrez KW - 4-formylphenyl-O-b-D-allopyranoside KW - EEG KW - PSL KW - hyposomnia KW - pain threshold SP - 386 EP - 393 JF - Journal of sleep research JO - J Sleep Res VL - 26 IS - 3 N2 - Natural helicid (4-formylphenyl-O-β-d-allopyranoside), a main active constituent from seeds of the Chinese herb Helicia nilagirica, has been reported to exert a sedative, analgesic and hypnotic effect, and is used clinically to treat neurasthenic syndrome, vascular headaches and trigeminal neuralgia. In the current study, mechanical allodynia tests, electroencephalograms, electromyogram recordings and c-Fos expression in neuropathic pain-like model mice of partial sciatic nerve ligation were used to investigate the effect of helicid on neuropathic pain and co-morbid insomnia. Our results showed that helicid at a dose of 100, 200 or 400 mg kg-1 could increase the mechanical threshold by 2.5-, 2.8- and 3.1-fold for 3 h after administration, respectively. Helicid at 200 and 400 mg kg-1 given at 07:00 hours increased the amount of non-rapid eye movement sleep in a 3-h period by 1.27- and 1.35-fold in partial sciatic nerve ligated mice. However, helicid (400 mg kg-1) given at 21:00 hours did not change the sleep pattern in normal mice. Immunohistochemical study showed that helicid (400 mg kg-1) administration could reverse the increase of c-Fos expression in the neurons of the rostral anterior cingulate cortex and tuberomammillary nucleus, and the decrease of c-Fos expression in the ventrolateral preoptic area caused by partial sciatic nerve ligation. These results indicate that helicid is an effective agent for both neuropathic pain and sleep disturbances in partial sciatic nerve ligated mice. SN - 1365-2869 UR - https://www.unboundmedicine.com/medline/citation/28318068/Helicid_alleviates_pain_and_sleep_disturbances_in_a_neuropathic_pain_like_model_in_mice_ L2 - https://doi.org/10.1111/jsr.12518 DB - PRIME DP - Unbound Medicine ER -