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P-selectin, endocan, and some adhesion molecules in obese children and adolescents with non-alcoholic fatty liver disease.
Scand J Clin Lab Invest 2017; 77(3):205-209SJ

Abstract

There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived from the endothelium and platelets in obese children and adolescents with NAFLD. One hundred obese patients and 40 lean controls were enrolled. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver. Blood samples were assayed for endocan, P-selectin, platelet-derived growth factor (PDGF), intercellular cell adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1. Obese patients with NAFLD presented higher ALT and insulin levels, as well as more profound dyslipidemia when compared with their counterparts without NAFLD. Serum levels of high-sensitivity C-reactive protein, VCAM-1 and ICAM-1 were found increased in both obese groups, regardless of NAFLD. In obese subjects with NAFLD, decreased P-selectin levels (51.6 ± 4.14 ng/mL) were detected as compared with the obese (72.3 ± 4.23) and control (74.2 ± 6.97) subjects. Furthermore, circulating P-selectin levels were closely associated with endocan levels (r = 0.852, p < 0.001). Childhood obesity leads to vascular inflammation and therefore may cause a predisposition to atherosclerosis at an early age. The possible outcome of decreased P-selectin levels with NAFLD development must be further investigated.

Authors+Show Affiliations

a Department of Pediatrics , Haseki Training and Research Hospital , Istanbul , Turkey.b Department of Biochemistry, Istanbul Faculty of Medicine , Istanbul University , Istanbul , Turkey.b Department of Biochemistry, Istanbul Faculty of Medicine , Istanbul University , Istanbul , Turkey.a Department of Pediatrics , Haseki Training and Research Hospital , Istanbul , Turkey.b Department of Biochemistry, Istanbul Faculty of Medicine , Istanbul University , Istanbul , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28318371

Citation

Ustyol, Ala, et al. "P-selectin, Endocan, and some Adhesion Molecules in Obese Children and Adolescents With Non-alcoholic Fatty Liver Disease." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 77, no. 3, 2017, pp. 205-209.
Ustyol A, Aycan Ustyol E, Gurdol F, et al. P-selectin, endocan, and some adhesion molecules in obese children and adolescents with non-alcoholic fatty liver disease. Scand J Clin Lab Invest. 2017;77(3):205-209.
Ustyol, A., Aycan Ustyol, E., Gurdol, F., Kokali, F., & Bekpınar, S. (2017). P-selectin, endocan, and some adhesion molecules in obese children and adolescents with non-alcoholic fatty liver disease. Scandinavian Journal of Clinical and Laboratory Investigation, 77(3), pp. 205-209. doi:10.1080/00365513.2017.1292363.
Ustyol A, et al. P-selectin, Endocan, and some Adhesion Molecules in Obese Children and Adolescents With Non-alcoholic Fatty Liver Disease. Scand J Clin Lab Invest. 2017;77(3):205-209. PubMed PMID: 28318371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - P-selectin, endocan, and some adhesion molecules in obese children and adolescents with non-alcoholic fatty liver disease. AU - Ustyol,Ala, AU - Aycan Ustyol,Esra, AU - Gurdol,Figen, AU - Kokali,Funda, AU - Bekpınar,Seldag, PY - 2017/3/21/entrez PY - 2017/3/21/pubmed PY - 2017/4/22/medline KW - Non-alcoholic fatty liver disease KW - P-selectin KW - endocan KW - intercellular cell adhesion molecule-1 KW - obesity KW - vascular cell adhesion molecule-1 SP - 205 EP - 209 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand. J. Clin. Lab. Invest. VL - 77 IS - 3 N2 - There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived from the endothelium and platelets in obese children and adolescents with NAFLD. One hundred obese patients and 40 lean controls were enrolled. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver. Blood samples were assayed for endocan, P-selectin, platelet-derived growth factor (PDGF), intercellular cell adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1. Obese patients with NAFLD presented higher ALT and insulin levels, as well as more profound dyslipidemia when compared with their counterparts without NAFLD. Serum levels of high-sensitivity C-reactive protein, VCAM-1 and ICAM-1 were found increased in both obese groups, regardless of NAFLD. In obese subjects with NAFLD, decreased P-selectin levels (51.6 ± 4.14 ng/mL) were detected as compared with the obese (72.3 ± 4.23) and control (74.2 ± 6.97) subjects. Furthermore, circulating P-selectin levels were closely associated with endocan levels (r = 0.852, p < 0.001). Childhood obesity leads to vascular inflammation and therefore may cause a predisposition to atherosclerosis at an early age. The possible outcome of decreased P-selectin levels with NAFLD development must be further investigated. SN - 1502-7686 UR - https://www.unboundmedicine.com/medline/citation/28318371/P_selectin_endocan_and_some_adhesion_molecules_in_obese_children_and_adolescents_with_non_alcoholic_fatty_liver_disease_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365513.2017.1292363 DB - PRIME DP - Unbound Medicine ER -