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Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection.
J Int Med Res. 2016 Dec; 44(6):1283-1291.JI

Abstract

Objective To investigate the effect of sperm DNA fragmentation on the fertilization rate, embryo development and pregnancy outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in a cohort of Chinese couples. Methods Infertile couples that had undergone assisted reproductive technology at our centre between January 2011 and December 2013 were included in this retrospective study. Fractions of prepared sperm samples were evaluated for sperm DNA fragmentation on the day of oocyte recovery. Results Of the 550 couples selected, 415 had undergone IVF and 135 ICSI. Sperm DNA fragmentation rate was significantly negatively correlated with the fertilization rate in the ICSI cycles but not the IVF cycles. No association was found between sperm DNA fragmentation and cleavage rate or good quality embryo formation rates in IVF or ICSI cycles. Receiver operating characteristic (ROC) curve analysis showed that the sperm DNA fragmentation rate was a statistically significant prognostic indicator of the clinical fertilization rate in ICSI cycles; a rate > 22.3% was associated with a lower fertilization rate following ICSI compared with a rate ≤ 22.3%. Conclusions High values of sperm DNA fragmentation were associated with a low fertilization rate following ICSI but were not associated with alterations in pregnancy or live birth rates in either ICSI or IVF in this cohort of Chinese couples.

Authors+Show Affiliations

1 Center for Reproductive Medicine, First Hospital, Jilin University, Changchun, China. 2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.1 Center for Reproductive Medicine, First Hospital, Jilin University, Changchun, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.2 Reproductive Medical and Genetic Centre, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.1 Center for Reproductive Medicine, First Hospital, Jilin University, Changchun, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28322098

Citation

Xue, Lin-Tao, et al. "Effect of Sperm DNA Fragmentation On Clinical Outcomes for Chinese Couples Undergoing in Vitro Fertilization or Intracytoplasmic Sperm Injection." The Journal of International Medical Research, vol. 44, no. 6, 2016, pp. 1283-1291.
Xue LT, Wang RX, He B, et al. Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection. J Int Med Res. 2016;44(6):1283-1291.
Xue, L. T., Wang, R. X., He, B., Mo, W. Y., Huang, L., Wang, S. K., Mao, X. B., Cheng, J. P., Huang, Y. Y., & Liu, R. (2016). Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection. The Journal of International Medical Research, 44(6), 1283-1291. https://doi.org/10.1177/0300060516664240
Xue LT, et al. Effect of Sperm DNA Fragmentation On Clinical Outcomes for Chinese Couples Undergoing in Vitro Fertilization or Intracytoplasmic Sperm Injection. J Int Med Res. 2016;44(6):1283-1291. PubMed PMID: 28322098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection. AU - Xue,Lin-Tao, AU - Wang,Rui-Xue, AU - He,Bing, AU - Mo,Wei-Ying, AU - Huang,Li, AU - Wang,Shi-Kai, AU - Mao,Xian-Bao, AU - Cheng,Jun-Ping, AU - Huang,Yue-Yue, AU - Liu,RuiZhi, Y1 - 2016/11/11/ PY - 2017/3/22/entrez PY - 2016/1/1/pubmed PY - 2017/7/1/medline KW - Sperm DNA fragmentation KW - fertilization rate KW - intracytoplasmic sperm injection KW - in vitro fertilization SP - 1283 EP - 1291 JF - The Journal of international medical research JO - J. Int. Med. Res. VL - 44 IS - 6 N2 - Objective To investigate the effect of sperm DNA fragmentation on the fertilization rate, embryo development and pregnancy outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in a cohort of Chinese couples. Methods Infertile couples that had undergone assisted reproductive technology at our centre between January 2011 and December 2013 were included in this retrospective study. Fractions of prepared sperm samples were evaluated for sperm DNA fragmentation on the day of oocyte recovery. Results Of the 550 couples selected, 415 had undergone IVF and 135 ICSI. Sperm DNA fragmentation rate was significantly negatively correlated with the fertilization rate in the ICSI cycles but not the IVF cycles. No association was found between sperm DNA fragmentation and cleavage rate or good quality embryo formation rates in IVF or ICSI cycles. Receiver operating characteristic (ROC) curve analysis showed that the sperm DNA fragmentation rate was a statistically significant prognostic indicator of the clinical fertilization rate in ICSI cycles; a rate > 22.3% was associated with a lower fertilization rate following ICSI compared with a rate ≤ 22.3%. Conclusions High values of sperm DNA fragmentation were associated with a low fertilization rate following ICSI but were not associated with alterations in pregnancy or live birth rates in either ICSI or IVF in this cohort of Chinese couples. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/28322098/Effect_of_sperm_DNA_fragmentation_on_clinical_outcomes_for_Chinese_couples_undergoing_in_vitro_fertilization_or_intracytoplasmic_sperm_injection_ L2 - http://journals.sagepub.com/doi/full/10.1177/0300060516664240?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -