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Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells.
Food Funct 2017; 8(4):1672-1679FF

Abstract

The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1β and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source.

Authors+Show Affiliations

REQUIMTE/LAQV, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal. iva.fernandes@fc.up.pt.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28322405

Citation

Oliveira, Hélder, et al. "Gastrointestinal Absorption, Antiproliferative and Anti-inflammatory Effect of the Major Carotenoids of Gardenia Jasminoides Ellis On Cancer Cells." Food & Function, vol. 8, no. 4, 2017, pp. 1672-1679.
Oliveira H, Cai X, Zhang Q, et al. Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells. Food Funct. 2017;8(4):1672-1679.
Oliveira, H., Cai, X., Zhang, Q., de Freitas, V., Mateus, N., He, J., & Fernandes, I. (2017). Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells. Food & Function, 8(4), pp. 1672-1679. doi:10.1039/c7fo00091j.
Oliveira H, et al. Gastrointestinal Absorption, Antiproliferative and Anti-inflammatory Effect of the Major Carotenoids of Gardenia Jasminoides Ellis On Cancer Cells. Food Funct. 2017 Apr 19;8(4):1672-1679. PubMed PMID: 28322405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal absorption, antiproliferative and anti-inflammatory effect of the major carotenoids of Gardenia jasminoides Ellis on cancer cells. AU - Oliveira,Hélder, AU - Cai,Xiaoshuang, AU - Zhang,Qian, AU - de Freitas,Victor, AU - Mateus,Nuno, AU - He,Jingren, AU - Fernandes,Iva, PY - 2017/3/23/pubmed PY - 2017/7/18/medline PY - 2017/3/22/entrez SP - 1672 EP - 1679 JF - Food & function JO - Food Funct VL - 8 IS - 4 N2 - The gastrointestinal absorption of the main carotenoids present in Gardenia jasminoides Ellis, crocetin, crocin-1 and crocin-2, was assayed through transport studies on MKN-28 and Caco-2 cell lines. Overall, crocetin was the compound that presented the highest gastrointestinal transport efficiency. Additionally, and since after absorption crocins are metabolized into crocetin, the antiproliferative capacity of crocetin was assayed in MKN-28 (stomach), MCF-7 (breast) and Caco-2 (colon) cancer cell lines. The results point to an antiproliferative effect of crocetin on the three cell lines tested. Anti-inflammatory properties were also assayed. Overall, crocetin showed a potential involvement in the downregulation of IL-1β and TNF-α but not IL-6. Altogether, these results suggest that these compounds can have an important role against cancer proliferation, highlighting the importance of Gardenia jasminoides Ellis as a nutraceutical food source. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/28322405/Gastrointestinal_absorption_antiproliferative_and_anti_inflammatory_effect_of_the_major_carotenoids_of_Gardenia_jasminoides_Ellis_on_cancer_cells_ L2 - https://doi.org/10.1039/c7fo00091j DB - PRIME DP - Unbound Medicine ER -