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Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection.
Ophthalmic Res 2017; 58(1):1-7OR

Abstract

AIM

We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators.

METHODS

The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores.

RESULTS

Mean best-corrected visual acuity was significantly improved at the control visit 0.15 ± 0.10 versus baseline 0.40 ± 0.20 logMAR (p < 0.05). Six eyes showed intraocular pressure spikes requiring topical antiglaucomatous treatment. Mean CFT and FA scores were significantly decreased versus baseline (CFT: 345 ± 50 μm; FA score: 3.4 ± 1.0) compared with the 12-week control visit (CFT: 219 ± 35 μm; FA score: 1.6 ± 1.1; p < 0.001).

CONCLUSION

Posterior sub-Tenon injection of triamcinolone acetonide significantly improved visual acuity and decrease macular edema in patients with intermediate uveitis associated with multiple sclerosis.

Authors+Show Affiliations

Department of Ophthalmology, Clinical Center Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28324879

Citation

Jovanović, Svetlana, et al. "Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection." Ophthalmic Research, vol. 58, no. 1, 2017, pp. 1-7.
Jovanović S, Šarenac Vulović T, Radotić F, et al. Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection. Ophthalmic Res. 2017;58(1):1-7.
Jovanović, S., Šarenac Vulović, T., Radotić, F., Tončić, Z., Živković, M., & Petrović, N. (2017). Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection. Ophthalmic Research, 58(1), pp. 1-7. doi:10.1159/000458157.
Jovanović S, et al. Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection. Ophthalmic Res. 2017;58(1):1-7. PubMed PMID: 28324879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection. AU - Jovanović,Svetlana, AU - Šarenac Vulović,Tatjana, AU - Radotić,Filip, AU - Tončić,Zorica, AU - Živković,Maja, AU - Petrović,Nenad, Y1 - 2017/03/22/ PY - 2016/11/28/received PY - 2017/01/25/accepted PY - 2017/3/23/pubmed PY - 2017/9/2/medline PY - 2017/3/22/entrez KW - Intermediate uveitis KW - Macular edema KW - Multiple sclerosis KW - Sub-Tenon capsule KW - Triamcinolone acetonide SP - 1 EP - 7 JF - Ophthalmic research JO - Ophthalmic Res. VL - 58 IS - 1 N2 - AIM: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators. METHODS: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores. RESULTS: Mean best-corrected visual acuity was significantly improved at the control visit 0.15 ± 0.10 versus baseline 0.40 ± 0.20 logMAR (p < 0.05). Six eyes showed intraocular pressure spikes requiring topical antiglaucomatous treatment. Mean CFT and FA scores were significantly decreased versus baseline (CFT: 345 ± 50 μm; FA score: 3.4 ± 1.0) compared with the 12-week control visit (CFT: 219 ± 35 μm; FA score: 1.6 ± 1.1; p < 0.001). CONCLUSION: Posterior sub-Tenon injection of triamcinolone acetonide significantly improved visual acuity and decrease macular edema in patients with intermediate uveitis associated with multiple sclerosis. SN - 1423-0259 UR - https://www.unboundmedicine.com/medline/citation/28324879/Quantitative_Analysis_of_Uveitis_Macular_Edema_in_Multiple_Sclerosis_Patients_Receiving_Deep_Posterior_Sub_Tenon_Triamcinolone_Acetonide_Injection_ L2 - https://www.karger.com?DOI=10.1159/000458157 DB - PRIME DP - Unbound Medicine ER -