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Hypofibrinogenemia Caused by Hemocoagulase After Colon Polyps Excision.
Am J Case Rep. 2017 Mar 22; 18:291-293.AJ

Abstract

BACKGROUND

In patients with large colon polyps, late-onset bleeding may be more likely to occur because of the larger cutting surface. In these patients, hemostatic agents may be applied to prevent the late-onset bleeding. A total of 7 patients developed hypofibrinogenemia caused by hemocoagulase following excision of colon polyps in our center from November to December 2015. CASE REPORT Seven patients underwent excision of colon polyps in our center from November to December 2015. The cutting face was large in these patients after surgery; therefore, hemocoagulase was used to prevent potential late-onset bleeding. Evaluation of clotting function showed that the fibrinogen level was normal before surgery in all 7 patients. Hemocoagulase was intravenously administered twice daily beginning from postoperative day 1. Hypofibrinogenemia of varying severity occurred 2-4 d later. Three patients also had lower-gastrointestinal bleeding. After drug withdrawal and infusion of fibrinogen, blood fibrinogen level gradually returned to normal. In contrast, among 13 patients who had not received hemocoagulase treatment for preventing hemorrhage following excision of colon polyps, detection of blood fibrinogen before surgery and 2-4 d after showed normal results.

CONCLUSIONS

Routine use of Hemocoagulase For Injection for the prevention of late-onset bleeding is not recommended for patients who have undergone excision of colon polyps. Hemocoagulase following excision of colon polyps can cause hypofibrinogenemia and even lower-gastrointestinal bleeding.

Authors+Show Affiliations

Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland).

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

28325889

Citation

Zhou, Hai-Bo. "Hypofibrinogenemia Caused By Hemocoagulase After Colon Polyps Excision." The American Journal of Case Reports, vol. 18, 2017, pp. 291-293.
Zhou HB. Hypofibrinogenemia Caused by Hemocoagulase After Colon Polyps Excision. Am J Case Rep. 2017;18:291-293.
Zhou, H. B. (2017). Hypofibrinogenemia Caused by Hemocoagulase After Colon Polyps Excision. The American Journal of Case Reports, 18, 291-293.
Zhou HB. Hypofibrinogenemia Caused By Hemocoagulase After Colon Polyps Excision. Am J Case Rep. 2017 Mar 22;18:291-293. PubMed PMID: 28325889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypofibrinogenemia Caused by Hemocoagulase After Colon Polyps Excision. A1 - Zhou,Hai-Bo, Y1 - 2017/03/22/ PY - 2017/3/23/entrez PY - 2017/3/23/pubmed PY - 2017/12/2/medline SP - 291 EP - 293 JF - The American journal of case reports JO - Am J Case Rep VL - 18 N2 - BACKGROUND In patients with large colon polyps, late-onset bleeding may be more likely to occur because of the larger cutting surface. In these patients, hemostatic agents may be applied to prevent the late-onset bleeding. A total of 7 patients developed hypofibrinogenemia caused by hemocoagulase following excision of colon polyps in our center from November to December 2015. CASE REPORT Seven patients underwent excision of colon polyps in our center from November to December 2015. The cutting face was large in these patients after surgery; therefore, hemocoagulase was used to prevent potential late-onset bleeding. Evaluation of clotting function showed that the fibrinogen level was normal before surgery in all 7 patients. Hemocoagulase was intravenously administered twice daily beginning from postoperative day 1. Hypofibrinogenemia of varying severity occurred 2-4 d later. Three patients also had lower-gastrointestinal bleeding. After drug withdrawal and infusion of fibrinogen, blood fibrinogen level gradually returned to normal. In contrast, among 13 patients who had not received hemocoagulase treatment for preventing hemorrhage following excision of colon polyps, detection of blood fibrinogen before surgery and 2-4 d after showed normal results. CONCLUSIONS Routine use of Hemocoagulase For Injection for the prevention of late-onset bleeding is not recommended for patients who have undergone excision of colon polyps. Hemocoagulase following excision of colon polyps can cause hypofibrinogenemia and even lower-gastrointestinal bleeding. SN - 1941-5923 UR - https://www.unboundmedicine.com/medline/citation/28325889/Hypofibrinogenemia_Caused_by_Hemocoagulase_After_Colon_Polyps_Excision_ L2 - https://www.amjcaserep.com/download/index/idArt/902059 DB - PRIME DP - Unbound Medicine ER -