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Immunological studies of pancytopenia in visceral leishmaniasis.
Isr J Med Sci. 1988 Feb; 24(2):70-4.IJ

Abstract

We report three cases of combined anemia, neutropenia and thrombocytopenia in patients with visceral leishmaniasis (kala-azar). Using immunofluorescence techniques and the common antiglobulin (Coombs') test, we showed membrane-associated antiplatelet, antineutrophil and antierythrocytic IgG antibodies in all three cases. Treatment with sodium stibogluconate raised the patients' platelet, neutrophil and erythrocyte count. At that time no antibodies were detected on peripheral blood cells. Immunological studies performed on these patients did not show marked abnormalities except for reduced T-helper cells and elevated OKM1-positive cells, which normalized after recovery. As bone marrow suppression was not found, it is suggested that pancytopenia resulted from rapid destruction of antibody-coated blood cells. Whether these antibodies are specific is not clear.

Authors+Show Affiliations

Pollack S
Division of Clinical Immunology, Rambam Medical Center, Haifa, Israel.
Nagler A
No affiliation info available
Liberman D
No affiliation info available
Oren I
No affiliation info available
Alroy G
No affiliation info available
Katz R
No affiliation info available
Schechter Y
No affiliation info available

MeSH

AdolescentAdultAntimony Sodium GluconateAutoantibodiesBlood Cell CountChild, PreschoolCoombs TestFemaleFluorescent Antibody TechniqueHumansImmunodiffusionImmunoglobulin GLeishmaniasis, VisceralMalePancytopenia

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

2833465

Citation

Pollack, S, et al. "Immunological Studies of Pancytopenia in Visceral Leishmaniasis." Israel Journal of Medical Sciences, vol. 24, no. 2, 1988, pp. 70-4.
Pollack S, Nagler A, Liberman D, et al. Immunological studies of pancytopenia in visceral leishmaniasis. Isr J Med Sci. 1988;24(2):70-4.
Pollack, S., Nagler, A., Liberman, D., Oren, I., Alroy, G., Katz, R., & Schechter, Y. (1988). Immunological studies of pancytopenia in visceral leishmaniasis. Israel Journal of Medical Sciences, 24(2), 70-4.
Pollack S, et al. Immunological Studies of Pancytopenia in Visceral Leishmaniasis. Isr J Med Sci. 1988;24(2):70-4. PubMed PMID: 2833465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunological studies of pancytopenia in visceral leishmaniasis. AU - Pollack,S, AU - Nagler,A, AU - Liberman,D, AU - Oren,I, AU - Alroy,G, AU - Katz,R, AU - Schechter,Y, PY - 1988/2/1/pubmed PY - 1988/2/1/medline PY - 1988/2/1/entrez SP - 70 EP - 4 JF - Israel journal of medical sciences JO - Isr J Med Sci VL - 24 IS - 2 N2 - We report three cases of combined anemia, neutropenia and thrombocytopenia in patients with visceral leishmaniasis (kala-azar). Using immunofluorescence techniques and the common antiglobulin (Coombs') test, we showed membrane-associated antiplatelet, antineutrophil and antierythrocytic IgG antibodies in all three cases. Treatment with sodium stibogluconate raised the patients' platelet, neutrophil and erythrocyte count. At that time no antibodies were detected on peripheral blood cells. Immunological studies performed on these patients did not show marked abnormalities except for reduced T-helper cells and elevated OKM1-positive cells, which normalized after recovery. As bone marrow suppression was not found, it is suggested that pancytopenia resulted from rapid destruction of antibody-coated blood cells. Whether these antibodies are specific is not clear. SN - 0021-2180 UR - https://www.unboundmedicine.com/medline/citation/2833465/Immunological_studies_of_pancytopenia_in_visceral_leishmaniasis_ DB - PRIME DP - Unbound Medicine ER -