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The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies.
Nutrients 2017; 9(3)N

Abstract

Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR". Fifteen observational studies involving 17,664 subjects were included. In this meta-analysis, type 2 diabetes patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of DR (odds ratio (OR) = 2.03, 95% confidence intervals (CI): 1.07, 3.86), and an obvious decrease of 1.7 ng/mL (95% CI: -2.72, -0.66) in serum vitamin D was demonstrated in the patients with diabetic retinopathy. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In conclusion, the evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of diabetic retinopathy in type 2 diabetes patients.

Authors+Show Affiliations

Department of Mental Health, Brain Hospital of Hunan Province, Changsha 410007, Hunan, China. luo276@126.com.Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, China. gfydsl@163.com.Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, China. powerestlulu@163.com. Department of Prevention Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China. powerestlulu@163.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

28335514

Citation

Luo, Bang-An, et al. "The Association Between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: a Meta-Analysis of Observational Studies." Nutrients, vol. 9, no. 3, 2017.
Luo BA, Gao F, Qin LL. The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies. Nutrients. 2017;9(3).
Luo, B. A., Gao, F., & Qin, L. L. (2017). The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies. Nutrients, 9(3), doi:10.3390/nu9030307.
Luo BA, Gao F, Qin LL. The Association Between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: a Meta-Analysis of Observational Studies. Nutrients. 2017 Mar 20;9(3) PubMed PMID: 28335514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Association between Vitamin D Deficiency and Diabetic Retinopathy in Type 2 Diabetes: A Meta-Analysis of Observational Studies. AU - Luo,Bang-An, AU - Gao,Fan, AU - Qin,Lu-Lu, Y1 - 2017/03/20/ PY - 2017/01/22/received PY - 2017/03/02/revised PY - 2017/03/15/accepted PY - 2017/3/25/entrez PY - 2017/3/25/pubmed PY - 2017/8/26/medline KW - diabetic retinopathy KW - meta-analysis KW - type 2 diabetes KW - vitamin D JF - Nutrients JO - Nutrients VL - 9 IS - 3 N2 - Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR". Fifteen observational studies involving 17,664 subjects were included. In this meta-analysis, type 2 diabetes patients with vitamin D deficiency (serum 25(OH)D levels <20 ng/mL) experienced a significantly increased risk of DR (odds ratio (OR) = 2.03, 95% confidence intervals (CI): 1.07, 3.86), and an obvious decrease of 1.7 ng/mL (95% CI: -2.72, -0.66) in serum vitamin D was demonstrated in the patients with diabetic retinopathy. Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In conclusion, the evidence from this meta-analysis indicates an association between vitamin D deficiency and an increased risk of diabetic retinopathy in type 2 diabetes patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28335514/The_Association_between_Vitamin_D_Deficiency_and_Diabetic_Retinopathy_in_Type_2_Diabetes:_A_Meta_Analysis_of_Observational_Studies_ L2 - http://www.mdpi.com/resolver?pii=nu9030307 DB - PRIME DP - Unbound Medicine ER -