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Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium.
Sci Rep. 2017 03 24; 7:45115.SR

Abstract

Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and pterygium is controversial. Meibomian gland dysfunction (MGD) is a common cause of dry eye and ocular discomfort but is often neglected, which may be the missing link between dry eye and pterygium. In this study, our data firstly revealed increased abnormality of meibomian gland structure and function in pterygium patients, representing with increased abnormality of MGD parameters such as meibum expression (P < 0.001) and meibomian gland loss (P < 0.001). Besides, the scores of MGD severity in patients with progressive pterygium were higher than those in patients with resting pterygium. The correlation between MGD parameters and ocular discomfort as well as dry eye indexes is also established. These findings suggest that MGD correlates to the tear film instability and ocular discomfort in patients with pterygium.

Authors+Show Affiliations

Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China. Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, 361005, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China. Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, 361005, China.Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, Xiamen, Fujian, 361001, China. Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian, 361005, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28338041

Citation

Wu, Huping, et al. "Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients With Pterygium." Scientific Reports, vol. 7, 2017, p. 45115.
Wu H, Lin Z, Yang F, et al. Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium. Sci Rep. 2017;7:45115.
Wu, H., Lin, Z., Yang, F., Fang, X., Dong, N., Luo, S., Shang, X., Li, W., & Liu, Z. (2017). Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium. Scientific Reports, 7, 45115. https://doi.org/10.1038/srep45115
Wu H, et al. Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients With Pterygium. Sci Rep. 2017 03 24;7:45115. PubMed PMID: 28338041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meibomian Gland Dysfunction Correlates to the Tear Film Instability and Ocular Discomfort in Patients with Pterygium. AU - Wu,Huping, AU - Lin,Zhirong, AU - Yang,Fan, AU - Fang,Xie, AU - Dong,Nuo, AU - Luo,Shunrong, AU - Shang,Xumin, AU - Li,Wei, AU - Liu,Zuguo, Y1 - 2017/03/24/ PY - 2016/11/14/received PY - 2017/02/16/accepted PY - 2017/3/25/entrez PY - 2017/3/25/pubmed PY - 2018/11/9/medline SP - 45115 EP - 45115 JF - Scientific reports JO - Sci Rep VL - 7 N2 - Pterygium is a very common disease in an eye clinic characterized by a benign proliferation of local conjunctiva that often crosses the limber of cornea and extends into corneal surface. Variety of studies has showed that pterygium is able to result in ocular discomfort and the change of ocular surface environment, such as dry eye. However, the link between abnormal tear film function and pterygium is controversial. Meibomian gland dysfunction (MGD) is a common cause of dry eye and ocular discomfort but is often neglected, which may be the missing link between dry eye and pterygium. In this study, our data firstly revealed increased abnormality of meibomian gland structure and function in pterygium patients, representing with increased abnormality of MGD parameters such as meibum expression (P < 0.001) and meibomian gland loss (P < 0.001). Besides, the scores of MGD severity in patients with progressive pterygium were higher than those in patients with resting pterygium. The correlation between MGD parameters and ocular discomfort as well as dry eye indexes is also established. These findings suggest that MGD correlates to the tear film instability and ocular discomfort in patients with pterygium. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28338041/Meibomian_Gland_Dysfunction_Correlates_to_the_Tear_Film_Instability_and_Ocular_Discomfort_in_Patients_with_Pterygium L2 - https://doi.org/10.1038/srep45115 DB - PRIME DP - Unbound Medicine ER -