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The role of diet in multiple sclerosis: A review.
Nutr Neurosci 2018; 21(6):377-390NN

Abstract

Multiple sclerosis (MS) is a multifactorial, inflammatory, and neurodegenerative disease of the central nervous system, where environmental factors interact with genetic susceptibility. The role of diet on MS has not been comprehensively elucidated; therefore, through an extensive search of relevant literature, this review reports the most significant evidence regarding nutrition as a possible co-factor influencing the inflammatory cascade by acting on both its molecular pathways and gut microbiota. Since nutritional status and dietary habits in MS patients have not been extensively reported, the lack of a scientific-based consensus on dietary recommendation in MS could encourage many patients to experiment alternative dietetic regimens, increasing the risk of malnutrition. This work investigates the health implications of an unbalanced diet in MS, and collects recent findings on nutrients of great interest among MS patients and physicians. The aim of this review is to elucidate the role of an accurate nutritional counseling in MS to move toward a multidisciplinary management of the disease and to encourage future studies demonstrating the role of a healthy diet on the onset and course of MS.

Authors+Show Affiliations

a I Clinic of Neurology, Second University of Naples , 80138 , Italy. b Department of Neuroscience, Psychology, Drug Research and Child Health , University of Florence , Italy.a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.a I Clinic of Neurology, Second University of Naples , 80138 , Italy.a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

28338444

Citation

Esposito, Sabrina, et al. "The Role of Diet in Multiple Sclerosis: a Review." Nutritional Neuroscience, vol. 21, no. 6, 2018, pp. 377-390.
Esposito S, Bonavita S, Sparaco M, et al. The role of diet in multiple sclerosis: A review. Nutr Neurosci. 2018;21(6):377-390.
Esposito, S., Bonavita, S., Sparaco, M., Gallo, A., & Tedeschi, G. (2018). The role of diet in multiple sclerosis: A review. Nutritional Neuroscience, 21(6), pp. 377-390. doi:10.1080/1028415X.2017.1303016.
Esposito S, et al. The Role of Diet in Multiple Sclerosis: a Review. Nutr Neurosci. 2018;21(6):377-390. PubMed PMID: 28338444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of diet in multiple sclerosis: A review. AU - Esposito,Sabrina, AU - Bonavita,Simona, AU - Sparaco,Maddalena, AU - Gallo,Antonio, AU - Tedeschi,Gioacchino, Y1 - 2017/03/24/ PY - 2017/3/25/pubmed PY - 2017/3/25/medline PY - 2017/3/25/entrez KW - Diet KW - Dietary recommendation KW - Gut microbiota KW - Inflammation KW - Malnutrition KW - Multiple sclerosis KW - Nutrients in multiple sclerosis KW - Nutritional assessment SP - 377 EP - 390 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 21 IS - 6 N2 - Multiple sclerosis (MS) is a multifactorial, inflammatory, and neurodegenerative disease of the central nervous system, where environmental factors interact with genetic susceptibility. The role of diet on MS has not been comprehensively elucidated; therefore, through an extensive search of relevant literature, this review reports the most significant evidence regarding nutrition as a possible co-factor influencing the inflammatory cascade by acting on both its molecular pathways and gut microbiota. Since nutritional status and dietary habits in MS patients have not been extensively reported, the lack of a scientific-based consensus on dietary recommendation in MS could encourage many patients to experiment alternative dietetic regimens, increasing the risk of malnutrition. This work investigates the health implications of an unbalanced diet in MS, and collects recent findings on nutrients of great interest among MS patients and physicians. The aim of this review is to elucidate the role of an accurate nutritional counseling in MS to move toward a multidisciplinary management of the disease and to encourage future studies demonstrating the role of a healthy diet on the onset and course of MS. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/28338444/The_role_of_diet_in_multiple_sclerosis:_A_review_ L2 - http://www.tandfonline.com/doi/full/10.1080/1028415X.2017.1303016 DB - PRIME DP - Unbound Medicine ER -