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The role of diet in multiple sclerosis: A review.

Abstract

Multiple sclerosis (MS) is a multifactorial, inflammatory, and neurodegenerative disease of the central nervous system, where environmental factors interact with genetic susceptibility. The role of diet on MS has not been comprehensively elucidated; therefore, through an extensive search of relevant literature, this review reports the most significant evidence regarding nutrition as a possible co-factor influencing the inflammatory cascade by acting on both its molecular pathways and gut microbiota. Since nutritional status and dietary habits in MS patients have not been extensively reported, the lack of a scientific-based consensus on dietary recommendation in MS could encourage many patients to experiment alternative dietetic regimens, increasing the risk of malnutrition. This work investigates the health implications of an unbalanced diet in MS, and collects recent findings on nutrients of great interest among MS patients and physicians. The aim of this review is to elucidate the role of an accurate nutritional counseling in MS to move toward a multidisciplinary management of the disease and to encourage future studies demonstrating the role of a healthy diet on the onset and course of MS.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    a I Clinic of Neurology, Second University of Naples , 80138 , Italy. b Department of Neuroscience, Psychology, Drug Research and Child Health , University of Florence , Italy.

    ,

    a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.

    ,

    a I Clinic of Neurology, Second University of Naples , 80138 , Italy.

    ,

    a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.

    a I Clinic of Neurology, Second University of Naples , 80138 , Italy. c MRI Research Center SUN-FISM, Second University of Naples , Italy. d Institute for Diagnosis and Care "Hermitage Capodimonte" , Naples , Italy.

    Source

    Nutritional neuroscience 21:6 2018 Jul pg 377-390

    MeSH

    Animals
    Antioxidants
    Body Composition
    Complementary Therapies
    Diet
    Disease Models, Animal
    Dysbiosis
    Fatty Acids
    Fatty Acids, Unsaturated
    Humans
    Inflammation
    Leptin
    Lipopolysaccharides
    Malnutrition
    Micronutrients
    Multiple Sclerosis
    Nutritional Status
    Obesity
    Osteoporosis
    Randomized Controlled Trials as Topic
    Recommended Dietary Allowances
    Risk Factors
    Vitamin D

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    28338444

    Citation

    Esposito, Sabrina, et al. "The Role of Diet in Multiple Sclerosis: a Review." Nutritional Neuroscience, vol. 21, no. 6, 2018, pp. 377-390.
    Esposito S, Bonavita S, Sparaco M, et al. The role of diet in multiple sclerosis: A review. Nutr Neurosci. 2018;21(6):377-390.
    Esposito, S., Bonavita, S., Sparaco, M., Gallo, A., & Tedeschi, G. (2018). The role of diet in multiple sclerosis: A review. Nutritional Neuroscience, 21(6), pp. 377-390. doi:10.1080/1028415X.2017.1303016.
    Esposito S, et al. The Role of Diet in Multiple Sclerosis: a Review. Nutr Neurosci. 2018;21(6):377-390. PubMed PMID: 28338444.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The role of diet in multiple sclerosis: A review. AU - Esposito,Sabrina, AU - Bonavita,Simona, AU - Sparaco,Maddalena, AU - Gallo,Antonio, AU - Tedeschi,Gioacchino, Y1 - 2017/03/24/ PY - 2017/3/25/pubmed PY - 2018/12/26/medline PY - 2017/3/25/entrez KW - Diet KW - Dietary recommendation KW - Gut microbiota KW - Inflammation KW - Malnutrition KW - Multiple sclerosis KW - Nutrients in multiple sclerosis KW - Nutritional assessment SP - 377 EP - 390 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 21 IS - 6 N2 - Multiple sclerosis (MS) is a multifactorial, inflammatory, and neurodegenerative disease of the central nervous system, where environmental factors interact with genetic susceptibility. The role of diet on MS has not been comprehensively elucidated; therefore, through an extensive search of relevant literature, this review reports the most significant evidence regarding nutrition as a possible co-factor influencing the inflammatory cascade by acting on both its molecular pathways and gut microbiota. Since nutritional status and dietary habits in MS patients have not been extensively reported, the lack of a scientific-based consensus on dietary recommendation in MS could encourage many patients to experiment alternative dietetic regimens, increasing the risk of malnutrition. This work investigates the health implications of an unbalanced diet in MS, and collects recent findings on nutrients of great interest among MS patients and physicians. The aim of this review is to elucidate the role of an accurate nutritional counseling in MS to move toward a multidisciplinary management of the disease and to encourage future studies demonstrating the role of a healthy diet on the onset and course of MS. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/28338444/The_role_of_diet_in_multiple_sclerosis:_A_review_ L2 - http://www.tandfonline.com/doi/full/10.1080/1028415X.2017.1303016 DB - PRIME DP - Unbound Medicine ER -