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Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles.
Clin Breast Cancer. 2017 11; 17(7):536-543.CB

Abstract

INTRODUCTION

The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance.

PATIENTS AND METHODS

All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed. The inclusion criterion was the surgical histopathologic examination findings of the entire lesion or radiologic follow-up data for ≥ 24 months. The exclusion criterion was the use of preoperative neoadjuvant therapy. The US-CNB results were compared with the surgical pathologic results or with the follow-up findings in the 3 needle size groups (14-, 16-, and 18-gauge). The needle size- and lesion characteristic-specific diagnostic accuracy parameters were evaluated. Statistical analysis was performed using a dedicated software program, and P ≤ .01 was considered significant.

RESULTS

A total of 1118 US-CNB cases (1042 patients) were included. Of the 1118 cases, 630 (56.3%) were in the 14-gauge group, 136 (12.2%) in the 16-gauge, and 352 (31.5%) in the 18-gauge needle group. Surgery was performed on 800 lesions (71.6%). Of these, 619 were malignant, 77 were high risk, and 104 were benign. The remaining 318 lesions (28.4%) underwent follow-up imaging studies. All the lesions were stable and, therefore, were considered benign. No differences were observed in the diagnostic accuracy parameters among the 3 needle size groups (P > .01). The false-negative rate was greater for lesions < 10 mm (7.2%) (P < .01) but without statistically significant differences among the 3 gauges (P > .01).

CONCLUSION

US-CNB performed with small needles (16 and 18 gauge) had the same diagnostic accuracy as that performed with 14-gauge needles, regardless of the lesion characteristics.

Authors+Show Affiliations

Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy. Electronic address: micgiuli@yahoo.it.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of General Surgery, Catholic University of the Sacred Heart, Rome, Italy.Department of Pathologic Anatomy, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.Department of Radiology, Catholic University of the Sacred Heart, Rome, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28342776

Citation

Giuliani, Michela, et al. "Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles." Clinical Breast Cancer, vol. 17, no. 7, 2017, pp. 536-543.
Giuliani M, Rinaldi P, Rella R, et al. Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles. Clin Breast Cancer. 2017;17(7):536-543.
Giuliani, M., Rinaldi, P., Rella, R., Fabrizi, G., Petta, F., Carlino, G., Di Leone, A., Mulè, A., Bufi, E., Romani, M., Belli, P., & Bonomo, L. (2017). Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles. Clinical Breast Cancer, 17(7), 536-543. https://doi.org/10.1016/j.clbc.2017.02.008
Giuliani M, et al. Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles. Clin Breast Cancer. 2017;17(7):536-543. PubMed PMID: 28342776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of Needle Size in Ultrasound-guided Core Needle Breast Biopsy: Comparison of 14-, 16-, and 18-Gauge Needles. AU - Giuliani,Michela, AU - Rinaldi,Pierluigi, AU - Rella,Rossella, AU - Fabrizi,Gina, AU - Petta,Federica, AU - Carlino,Giorgio, AU - Di Leone,Alba, AU - Mulè,Antonino, AU - Bufi,Enida, AU - Romani,Maurizio, AU - Belli,Paolo, AU - Bonomo,Lorenzo, Y1 - 2017/03/06/ PY - 2016/10/30/received PY - 2017/02/26/revised PY - 2017/02/27/accepted PY - 2017/3/28/pubmed PY - 2018/6/28/medline PY - 2017/3/27/entrez KW - Breast KW - Core needle biopsy KW - Diagnosis KW - Needles KW - Ultrasound SP - 536 EP - 543 JF - Clinical breast cancer JO - Clin Breast Cancer VL - 17 IS - 7 N2 - INTRODUCTION: The aim of the present study was to assess the diagnostic accuracy of ultrasound-guided core needle biopsy (US-CNB) of breast lesions, comparing smaller needles (16- and 18-gauge) with the 14-gauge needle, and to analyze the lesion characteristics influencing US-CNB diagnostic performance. PATIENTS AND METHODS: All the patients provided informed consent before the biopsy procedure. The data from breast lesions that had undergone US-CNB in our institution from January 2011 to January 2015 were retrospectively reviewed. The inclusion criterion was the surgical histopathologic examination findings of the entire lesion or radiologic follow-up data for ≥ 24 months. The exclusion criterion was the use of preoperative neoadjuvant therapy. The US-CNB results were compared with the surgical pathologic results or with the follow-up findings in the 3 needle size groups (14-, 16-, and 18-gauge). The needle size- and lesion characteristic-specific diagnostic accuracy parameters were evaluated. Statistical analysis was performed using a dedicated software program, and P ≤ .01 was considered significant. RESULTS: A total of 1118 US-CNB cases (1042 patients) were included. Of the 1118 cases, 630 (56.3%) were in the 14-gauge group, 136 (12.2%) in the 16-gauge, and 352 (31.5%) in the 18-gauge needle group. Surgery was performed on 800 lesions (71.6%). Of these, 619 were malignant, 77 were high risk, and 104 were benign. The remaining 318 lesions (28.4%) underwent follow-up imaging studies. All the lesions were stable and, therefore, were considered benign. No differences were observed in the diagnostic accuracy parameters among the 3 needle size groups (P > .01). The false-negative rate was greater for lesions < 10 mm (7.2%) (P < .01) but without statistically significant differences among the 3 gauges (P > .01). CONCLUSION: US-CNB performed with small needles (16 and 18 gauge) had the same diagnostic accuracy as that performed with 14-gauge needles, regardless of the lesion characteristics. SN - 1938-0666 UR - https://www.unboundmedicine.com/medline/citation/28342776/Effect_of_Needle_Size_in_Ultrasound_guided_Core_Needle_Breast_Biopsy:_Comparison_of_14__16__and_18_Gauge_Needles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-8209(16)30423-2 DB - PRIME DP - Unbound Medicine ER -