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Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation.
Clin Exp Allergy. 2017 Aug; 47(8):1014-1021.CE

Abstract

BACKGROUND

In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children.

OBJECTIVE

To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD.

METHODS

A total of 415 pregnant women were randomized to ingest a combination of Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. lactis Bb-12 (Bb-12) and Lactobacillus acidophilus La-5 (La-5) or placebo, and their offspring were assessed for AD during the first 2 years of life. Peripheral blood collected at 3 months of age was analysed for regulatory T cells (n=140) and Th subsets (n=77) including Th1, Th2, Th9, Th17 and Th22.

RESULTS

The proportion of Th22 cells was reduced in children in the probiotic group compared to the placebo group (median 0.038% vs 0.064%, P=.009). The difference between the probiotic and placebo groups was also observed in the children who did not develop AD during the 2-year follow-up. The proportion of Th22 cells was increased in children who developed AD compared to the children who did not develop AD (0.090% vs 0.044%, P<.001). Mediation analysis indicated that the preventive effect of probiotics was partially mediated through the reduction in Th22 cells.

CONCLUSION

Perinatal maternal probiotic supplementation with a combination of LGG, Bb-12 and La-5 reduced the proportion of Th22 cells in 3-month-old children. This may partially explain the preventive effect of probiotics on AD.

Authors+Show Affiliations

Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Department of Immunology and Transfusion Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.Department of Cancer Research and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway. Department of Pediatrics, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.Department of Immunology and Transfusion Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

28346719

Citation

Rø, A D B., et al. "Reduced Th22 Cell Proportion and Prevention of Atopic Dermatitis in Infants Following Maternal Probiotic Supplementation." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 47, no. 8, 2017, pp. 1014-1021.
Rø ADB, Simpson MR, Rø TB, et al. Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clin Exp Allergy. 2017;47(8):1014-1021.
Rø, A. D. B., Simpson, M. R., Rø, T. B., Storrø, O., Johnsen, R., Videm, V., & Øien, T. (2017). Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 47(8), 1014-1021. https://doi.org/10.1111/cea.12930
Rø ADB, et al. Reduced Th22 Cell Proportion and Prevention of Atopic Dermatitis in Infants Following Maternal Probiotic Supplementation. Clin Exp Allergy. 2017;47(8):1014-1021. PubMed PMID: 28346719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced Th22 cell proportion and prevention of atopic dermatitis in infants following maternal probiotic supplementation. AU - Rø,A D B, AU - Simpson,M R, AU - Rø,T B, AU - Storrø,O, AU - Johnsen,R, AU - Videm,V, AU - Øien,T, Y1 - 2017/04/21/ PY - 2016/09/21/received PY - 2017/01/19/revised PY - 2017/03/16/accepted PY - 2017/3/28/pubmed PY - 2018/4/18/medline PY - 2017/3/28/entrez KW - ProPACT KW - T cells KW - Th1 KW - Th17 KW - Th2 KW - Th22 KW - atopic dermatitis KW - probiotic KW - regulatory T cell SP - 1014 EP - 1021 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 47 IS - 8 N2 - BACKGROUND: In the randomized, controlled study Probiotics in the Prevention of Allergy among Children in Trondheim (ProPACT), maternal probiotic supplementation reduced the incidence of atopic dermatitis (AD) in the offspring. In the current study, we hypothesized that the effect was mediated by a shift in the T helper (Th) cells in the children. OBJECTIVE: To examine whether Th cell proportions were affected by maternal probiotic supplementation and thus could mediate the preventive effect of probiotics on AD. METHODS: A total of 415 pregnant women were randomized to ingest a combination of Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. lactis Bb-12 (Bb-12) and Lactobacillus acidophilus La-5 (La-5) or placebo, and their offspring were assessed for AD during the first 2 years of life. Peripheral blood collected at 3 months of age was analysed for regulatory T cells (n=140) and Th subsets (n=77) including Th1, Th2, Th9, Th17 and Th22. RESULTS: The proportion of Th22 cells was reduced in children in the probiotic group compared to the placebo group (median 0.038% vs 0.064%, P=.009). The difference between the probiotic and placebo groups was also observed in the children who did not develop AD during the 2-year follow-up. The proportion of Th22 cells was increased in children who developed AD compared to the children who did not develop AD (0.090% vs 0.044%, P<.001). Mediation analysis indicated that the preventive effect of probiotics was partially mediated through the reduction in Th22 cells. CONCLUSION: Perinatal maternal probiotic supplementation with a combination of LGG, Bb-12 and La-5 reduced the proportion of Th22 cells in 3-month-old children. This may partially explain the preventive effect of probiotics on AD. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/28346719/Reduced_Th22_cell_proportion_and_prevention_of_atopic_dermatitis_in_infants_following_maternal_probiotic_supplementation_ L2 - https://doi.org/10.1111/cea.12930 DB - PRIME DP - Unbound Medicine ER -