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Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis.
Pharm Biol. 2017 Dec; 55(1):1473-1482.PB

Abstract

CONTEXT

Helicteres vegae Cristóbal (Sterculiaceae) (Hv) and Heliopsis sinaloensis B.L. Turner (Asteraceae) (Hs) are endangered and poorly studied plant species; related plants have been used against chronic-degenerative and infectious diseases. Therefore, Hv and Hs could be sources of bioactive compounds against these illnesses.

OBJECTIVE

To determine the chemical composition and biological activities (antioxidant, antimutagenic and antimicrobial) of Hv and Hs leaves (L) and stems (S).

MATERIALS AND METHODS

Methanol extracts (ME) of each plant/tissue were evaluated for their phytochemicals; phenolics (HPLC-DAD-ESI-MS); antioxidant activity (AA) (0.125-4 mg/mL) (DPPH, ABTS, ORAC and β-carotene discoloration); antimutagenicity (0.5 and 1 mg/plate) (Ames assay, tester strain Salmonella enterica serovar Typhimurium YG1024, 1-nitropyrene as mutagen); activity against human pathogens (1 mg/mL); and toxicity (0.01-2 mg/mL) (Artemia salina assay).

RESULTS

All ME showed flavonoids and triterpenes/steroids. The ME-SHv had the highest content of total phenolics (TP) (2245.82 ± 21.45 mg GAE/100 g d.w.) and condensed tannins (603.71 ± 1.115 mg CE/100 g d.w.). The compounds identified were flavonoids (kaempferol 7-O-coumaroylhexoside, and two kaempferol 7-O-rhamnosylhexosides) and phenolics [rosmarinic acid, and 3'-O-(8″-Z-caffeoyl) rosmarinic acid]. The ME-LHs showed the highest content of flavonoids (357.88 mg RE/g d.w.) and phenolic acids (238.58 mg CAE/g d.w.) by HPLC. The ME-SHv showed the highest AA. All ME were strong antimutagens (63.3-85.7%). Only the Hs extracts were toxic (ME-LHs, LC50 = 94.9 ± 1.7 μg/mL; ME-SHs, LC50 = 89.03 ± 4.42 μg/mL).

DISCUSSION AND CONCLUSIONS

Both Hv and Hs are potential sources of preventive and therapeutic agents against chronic-degenerative diseases.

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Authors+Show Affiliations

Olivas-Quintero S
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
López-Angulo G
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
Montes-Avila J
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
Díaz-Camacho SP
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
Vega-Aviña R
b School of Agronomy, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
López-Valenzuela JÁ
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
Salazar-Salas NY
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.
Delgado-Vargas F
a School of Chemical and Biological Sciences, Autonomous University of Sinaloa , Culiacan , Sinaloa , Mexico.

MeSH

AnimalsAnti-Infective AgentsAntimutagenic AgentsAntioxidantsArtemiaAsteraceaeBacteriaBenzothiazolesBiphenyl CompoundsChromatography, High Pressure LiquidGiardia lambliaMalvaceaeMethanolMicrobial Sensitivity TestsMutagenicity TestsOxygen Radical Absorbance CapacityParasitic Sensitivity TestsPhytotherapyPicratesPlant ExtractsPlant LeavesPlant StemsPlants, MedicinalSalmonella typhimuriumSolventsSpectrometry, Mass, Electrospray IonizationSulfonic Acidsbeta Carotene

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28347185

Citation

Olivas-Quintero, Sandra, et al. "Chemical Composition and Biological Activities of Helicteres Vegae and Heliopsis Sinaloensis." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 1473-1482.
Olivas-Quintero S, López-Angulo G, Montes-Avila J, et al. Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis. Pharm Biol. 2017;55(1):1473-1482.
Olivas-Quintero, S., López-Angulo, G., Montes-Avila, J., Díaz-Camacho, S. P., Vega-Aviña, R., López-Valenzuela, J. Á., Salazar-Salas, N. Y., & Delgado-Vargas, F. (2017). Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis. Pharmaceutical Biology, 55(1), 1473-1482. https://doi.org/10.1080/13880209.2017.1306712
Olivas-Quintero S, et al. Chemical Composition and Biological Activities of Helicteres Vegae and Heliopsis Sinaloensis. Pharm Biol. 2017;55(1):1473-1482. PubMed PMID: 28347185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemical composition and biological activities of Helicteres vegae and Heliopsis sinaloensis. AU - Olivas-Quintero,Sandra, AU - López-Angulo,Gabriela, AU - Montes-Avila,Julio, AU - Díaz-Camacho,Sylvia Páz, AU - Vega-Aviña,Rito, AU - López-Valenzuela,José Ángel, AU - Salazar-Salas,Nancy Yareli, AU - Delgado-Vargas,Francisco, PY - 2017/3/29/entrez PY - 2017/3/30/pubmed PY - 2017/6/6/medline KW - Phenolics KW - antimicrobial KW - antimutagenic KW - antioxidant KW - electrospray ionization KW - flavonoids KW - liquid chromatography KW - mass spectrometry KW - toxicity SP - 1473 EP - 1482 JF - Pharmaceutical biology JO - Pharm Biol VL - 55 IS - 1 N2 - CONTEXT: Helicteres vegae Cristóbal (Sterculiaceae) (Hv) and Heliopsis sinaloensis B.L. Turner (Asteraceae) (Hs) are endangered and poorly studied plant species; related plants have been used against chronic-degenerative and infectious diseases. Therefore, Hv and Hs could be sources of bioactive compounds against these illnesses. OBJECTIVE: To determine the chemical composition and biological activities (antioxidant, antimutagenic and antimicrobial) of Hv and Hs leaves (L) and stems (S). MATERIALS AND METHODS: Methanol extracts (ME) of each plant/tissue were evaluated for their phytochemicals; phenolics (HPLC-DAD-ESI-MS); antioxidant activity (AA) (0.125-4 mg/mL) (DPPH, ABTS, ORAC and β-carotene discoloration); antimutagenicity (0.5 and 1 mg/plate) (Ames assay, tester strain Salmonella enterica serovar Typhimurium YG1024, 1-nitropyrene as mutagen); activity against human pathogens (1 mg/mL); and toxicity (0.01-2 mg/mL) (Artemia salina assay). RESULTS: All ME showed flavonoids and triterpenes/steroids. The ME-SHv had the highest content of total phenolics (TP) (2245.82 ± 21.45 mg GAE/100 g d.w.) and condensed tannins (603.71 ± 1.115 mg CE/100 g d.w.). The compounds identified were flavonoids (kaempferol 7-O-coumaroylhexoside, and two kaempferol 7-O-rhamnosylhexosides) and phenolics [rosmarinic acid, and 3'-O-(8″-Z-caffeoyl) rosmarinic acid]. The ME-LHs showed the highest content of flavonoids (357.88 mg RE/g d.w.) and phenolic acids (238.58 mg CAE/g d.w.) by HPLC. The ME-SHv showed the highest AA. All ME were strong antimutagens (63.3-85.7%). Only the Hs extracts were toxic (ME-LHs, LC50 = 94.9 ± 1.7 μg/mL; ME-SHs, LC50 = 89.03 ± 4.42 μg/mL). DISCUSSION AND CONCLUSIONS: Both Hv and Hs are potential sources of preventive and therapeutic agents against chronic-degenerative diseases. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/28347185/Chemical_composition_and_biological_activities_of_Helicteres_vegae_and_Heliopsis_sinaloensis_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1306712 DB - PRIME DP - Unbound Medicine ER -