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The anti-dermatophyte activity of Zataria multiflora essential oils.
J Mycol Med. 2017 Jun; 27(2):232-237.JM

Abstract

OBJECTIVE

Dermtophytes are a group of pathogenic fungi and the major cause of dermatophytosis in humans and animals. Fighting dermatophytes by natural essential oils is one important issue in new researches.

MATERIALS AND METHODS

In this investigation, we evaluated the anti-dermatophyte activities of three samples of Z. multiflora essential oils against dermatophytes along with analysis of chemical compositions of the essential oils and their anti-elastase activities on elastase production in dermatophytes.

RESULTS

Carvacrol (1.5-34.4%), thymol (25.8-41.2%), carvacrol methyl ether (1.9-28.3%) and p-cymene (2.3-8.3%) were the main components of Z. multiflora essential oils. Z. multiflora essential oils (100ppm) inhibited the mycelium growth of dermatophytes (6±1.7-47.0±1.4%) and had the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of 0.03-0.25μl/ml against dermatophytes. Essential oils inhibited elastase produced in dermatophytes and pure porcine elastase.

CONCLUSION

Z. multiflora essential oils can be used as natural anti-dermatophyte agent for fighting dermatophytes in further preclinical and clinical studies.

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Authors+Show Affiliations

Mahboubi M
Department of Microbiology, Medicinal Plants, Research Center of Barij, Kashan, Iran. Electronic address: mahboubi1357@yahoo.com.
HeidaryTabar R
Department of Microbiology, Medicinal Plants, Research Center of Barij, Kashan, Iran.
Mahdizadeh E
Department of Microbiology, Medicinal Plants, Research Center of Barij, Kashan, Iran.

MeSH

AnimalsAntifungal AgentsArthrodermataceaeHumansLamiaceaeMicrobial Sensitivity TestsOils, VolatilePancreatic ElastasePlant OilsSwineTinea

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28347599

Citation

Mahboubi, M, et al. "The Anti-dermatophyte Activity of Zataria Multiflora Essential Oils." Journal De Mycologie Medicale, vol. 27, no. 2, 2017, pp. 232-237.
Mahboubi M, HeidaryTabar R, Mahdizadeh E. The anti-dermatophyte activity of Zataria multiflora essential oils. J Mycol Med. 2017;27(2):232-237.
Mahboubi, M., HeidaryTabar, R., & Mahdizadeh, E. (2017). The anti-dermatophyte activity of Zataria multiflora essential oils. Journal De Mycologie Medicale, 27(2), 232-237. https://doi.org/10.1016/j.mycmed.2017.03.001
Mahboubi M, HeidaryTabar R, Mahdizadeh E. The Anti-dermatophyte Activity of Zataria Multiflora Essential Oils. J Mycol Med. 2017;27(2):232-237. PubMed PMID: 28347599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The anti-dermatophyte activity of Zataria multiflora essential oils. AU - Mahboubi,M, AU - HeidaryTabar,R, AU - Mahdizadeh,E, Y1 - 2017/03/24/ PY - 2016/02/02/received PY - 2017/02/04/revised PY - 2017/03/02/accepted PY - 2017/3/30/pubmed PY - 2018/4/3/medline PY - 2017/3/29/entrez KW - Antifungal KW - Dermatophyte KW - Elastase KW - Essential oil KW - Zataria multiflora SP - 232 EP - 237 JF - Journal de mycologie medicale JO - J Mycol Med VL - 27 IS - 2 N2 - OBJECTIVE: Dermtophytes are a group of pathogenic fungi and the major cause of dermatophytosis in humans and animals. Fighting dermatophytes by natural essential oils is one important issue in new researches. MATERIALS AND METHODS: In this investigation, we evaluated the anti-dermatophyte activities of three samples of Z. multiflora essential oils against dermatophytes along with analysis of chemical compositions of the essential oils and their anti-elastase activities on elastase production in dermatophytes. RESULTS: Carvacrol (1.5-34.4%), thymol (25.8-41.2%), carvacrol methyl ether (1.9-28.3%) and p-cymene (2.3-8.3%) were the main components of Z. multiflora essential oils. Z. multiflora essential oils (100ppm) inhibited the mycelium growth of dermatophytes (6±1.7-47.0±1.4%) and had the minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) values of 0.03-0.25μl/ml against dermatophytes. Essential oils inhibited elastase produced in dermatophytes and pure porcine elastase. CONCLUSION: Z. multiflora essential oils can be used as natural anti-dermatophyte agent for fighting dermatophytes in further preclinical and clinical studies. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/28347599/The_anti_dermatophyte_activity_of_Zataria_multiflora_essential_oils_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1156-5233(17)30062-8 DB - PRIME DP - Unbound Medicine ER -