Maraschin, Jhonatan Christian, et al. "Participation of Dorsal Periaqueductal Gray 5-HT1A Receptors in the Panicolytic-like Effect of the Κ-opioid Receptor Antagonist Nor-BNI." Behavioural Brain Research, vol. 327, 2017, pp. 75-82.
Maraschin JC, Almeida CB, Rangel MP, et al. Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the κ-opioid receptor antagonist Nor-BNI. Behav Brain Res. 2017;327:75-82.
Maraschin, J. C., Almeida, C. B., Rangel, M. P., Roncon, C. M., Sestile, C. C., Zangrossi, H., Graeff, F. G., & Audi, E. A. (2017). Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the κ-opioid receptor antagonist Nor-BNI. Behavioural Brain Research, 327, 75-82. https://doi.org/10.1016/j.bbr.2017.03.033
Maraschin JC, et al. Participation of Dorsal Periaqueductal Gray 5-HT1A Receptors in the Panicolytic-like Effect of the Κ-opioid Receptor Antagonist Nor-BNI. Behav Brain Res. 2017 06 1;327:75-82. PubMed PMID: 28347824.
TY - JOUR
T1 - Participation of dorsal periaqueductal gray 5-HT1A receptors in the panicolytic-like effect of the κ-opioid receptor antagonist Nor-BNI.
AU - Maraschin,Jhonatan Christian,
AU - Almeida,Camila Biesdorf,
AU - Rangel,Marcel Pereira,
AU - Roncon,Camila Marroni,
AU - Sestile,Caio César,
AU - Zangrossi,Hélio,Jr
AU - Graeff,Frederico Guilherme,
AU - Audi,Elisabeth Aparecida,
Y1 - 2017/03/24/
PY - 2016/12/06/received
PY - 2017/03/15/revised
PY - 2017/03/21/accepted
PY - 2017/3/30/pubmed
PY - 2017/12/20/medline
PY - 2017/3/29/entrez
KW - 8-OH-DPAT hydrobromide (PubChem CID: 6917794)
KW - CTOP (PubChem CID: 5311058)
KW - Dorsal periaqueductal gray
KW - Elevated T-maze
KW - Panic disorder
KW - WAY-100635 maleate salt (PubChem CID: 11957721)
KW - dPAG electrical stimulation
KW - nor-binaltorphimine dihydrochloride (PubChem CID: 11957626)
KW - κ-opioid receptor 5-HT(1A) receptor
SP - 75
EP - 82
JF - Behavioural brain research
JO - Behav Brain Res
VL - 327
N2 - Panic patients may have abnormalities in serotonergic and opioidergic neurotransmission. The dorsal periaqueductal gray (dPAG) plays an important role in organizing proximal defense, related to panic attacks. The 5-HT1A receptor (5-HT1A-R) is involved in regulating escape behavior that is organized in the dPAG. Activation of κ-opioid receptor (KOR) in this region causes anxiogenic effects. In this study, we investigated the involvement of KOR in regulating escape behavior, using systemic and intra-dPAG injection of the KOR antagonist Nor-BNI. As panic models, we used the elevated T-maze (ETM) and the dPAG electrical stimulation test (EST). We also evaluated whether activation of the 5-HT1A-R or the μ-opioid receptor (MOR) in the dPAG contributes to the Nor-BNI effects. The results showed that systemic administration of Nor-BNI, either subcutaneously (2.0 and 4.0mg/kg) or intraperitoneally (2.0mg/kg), impaired escape in the EST, indicating a panicolytic-like effect. Intra-dPAG injection of this antagonist (6.8nmol) caused the same effect in the EST and in the ETM. Association of ineffective doses of Nor-BNI and the 5-HT1A-R agonist 8-OH-DPAT caused panicolytic-like effect in these two tests. Previous administration of the 5-HT1A-R antagonist WAY-100635, but not of the MOR antagonist CTOP, blocked the panicolytic-like effect of Nor-BNI. These results indicate that KOR enhances proximal defense in the dPAG through 5-HT1A-R modulation, independently of MOR. Because former results indicate that the 5-HT1A-R is involved in the antipanic action of antidepressants, KOR antagonists may be useful as adjunctive or alternative drug treatment of panic disorder.
SN - 1872-7549
UR - https://www.unboundmedicine.com/medline/citation/28347824/Participation_of_dorsal_periaqueductal_gray_5_HT1A_receptors_in_the_panicolytic_like_effect_of_the_κ_opioid_receptor_antagonist_Nor_BNI_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(16)31211-6
DB - PRIME
DP - Unbound Medicine