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Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage.
Sci Rep. 2017 03 28; 7:45342.SR

Abstract

To systematically study the chemical constituents in Magnolia officinalis var. biloba fruits, nine phenylethanoid glycosides were isolated by solvent extraction, silica gel, and preparative high-performance liquid chromatography (HPLC). Their structures were elucidated by 1D and 2D NMR analyses, including COSY, HMQC and HMBC correlations, and HPLC analysis of sugar residue. Nine phenylethanoid glycosides, namely, magnoloside Ia (1), magnoloside Ic (2), crassifolioside (3), magnoloside Ib (4), magnoloside IIIa (5), magnoloside IVa (6), magnoloside IIa (7), magnoloside IIb (8) and magnoloside Va (9), were first isolated from the n-butanol fraction of Magnolia officinalis var. biloba fruits alcohol extract. Free radical scavenging activities of the nine phenylethanoid glycosides were assessed using the DPPH, ABTS, and superoxide anion radical scavenging assays. Simultaneously, protective effects of all compounds against free radical-induced oxidative damage were evaluated by two different kinds of mitochondrial damage model. The protective effects were assessed by mitochondrial swelling, the formations of malondialdehyde (MDA) and lipid hydroperoxide (LOOH), the activities of catalase (CAT), glutathione reductase (GR) and superoxide dismutase (SOD). All phenylethanoid glycosides showed significant protective effects.

Authors+Show Affiliations

Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China.Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, P. R. China. MOE Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University, Wuhan 430072, P. R. China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28349971

Citation

Ge, Lanlan, et al. "Nine Phenylethanoid Glycosides From Magnolia Officinalis Var. Biloba Fruits and Their Protective Effects Against Free Radical-induced Oxidative Damage." Scientific Reports, vol. 7, 2017, p. 45342.
Ge L, Zhang W, Zhou G, et al. Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage. Sci Rep. 2017;7:45342.
Ge, L., Zhang, W., Zhou, G., Ma, B., Mo, Q., Chen, Y., & Wang, Y. (2017). Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage. Scientific Reports, 7, 45342. https://doi.org/10.1038/srep45342
Ge L, et al. Nine Phenylethanoid Glycosides From Magnolia Officinalis Var. Biloba Fruits and Their Protective Effects Against Free Radical-induced Oxidative Damage. Sci Rep. 2017 03 28;7:45342. PubMed PMID: 28349971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nine phenylethanoid glycosides from Magnolia officinalis var. biloba fruits and their protective effects against free radical-induced oxidative damage. AU - Ge,Lanlan, AU - Zhang,Wenhui, AU - Zhou,Gao, AU - Ma,Bingxin, AU - Mo,Qigui, AU - Chen,Yuxin, AU - Wang,Youwei, Y1 - 2017/03/28/ PY - 2016/11/08/received PY - 2017/02/23/accepted PY - 2017/3/29/entrez PY - 2017/3/30/pubmed PY - 2018/11/14/medline SP - 45342 EP - 45342 JF - Scientific reports JO - Sci Rep VL - 7 N2 - To systematically study the chemical constituents in Magnolia officinalis var. biloba fruits, nine phenylethanoid glycosides were isolated by solvent extraction, silica gel, and preparative high-performance liquid chromatography (HPLC). Their structures were elucidated by 1D and 2D NMR analyses, including COSY, HMQC and HMBC correlations, and HPLC analysis of sugar residue. Nine phenylethanoid glycosides, namely, magnoloside Ia (1), magnoloside Ic (2), crassifolioside (3), magnoloside Ib (4), magnoloside IIIa (5), magnoloside IVa (6), magnoloside IIa (7), magnoloside IIb (8) and magnoloside Va (9), were first isolated from the n-butanol fraction of Magnolia officinalis var. biloba fruits alcohol extract. Free radical scavenging activities of the nine phenylethanoid glycosides were assessed using the DPPH, ABTS, and superoxide anion radical scavenging assays. Simultaneously, protective effects of all compounds against free radical-induced oxidative damage were evaluated by two different kinds of mitochondrial damage model. The protective effects were assessed by mitochondrial swelling, the formations of malondialdehyde (MDA) and lipid hydroperoxide (LOOH), the activities of catalase (CAT), glutathione reductase (GR) and superoxide dismutase (SOD). All phenylethanoid glycosides showed significant protective effects. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28349971/Nine_phenylethanoid_glycosides_from_Magnolia_officinalis_var__biloba_fruits_and_their_protective_effects_against_free_radical_induced_oxidative_damage_ L2 - http://dx.doi.org/10.1038/srep45342 DB - PRIME DP - Unbound Medicine ER -