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Fasting but not casual blood glucose is associated with pancreatic cancer mortality in Japanese: EPOCH-JAPAN.

Abstract

PURPOSE

The dose-response relationship between fasting blood glucose levels and risk of pancreatic cancer has been investigated, but the association between casual blood glucose levels and pancreatic cancer death has not been examined. We examined the association between casual and fasting blood glucose levels and death due to pancreatic cancer in Japanese.

METHODS

We performed a pooled analysis of the individual Japanese including 46,387 participants aged 40-79 years from ten cohorts. Participants were classified into five groups: low normal, middle normal, high normal, prediabetes (casual blood glucose 140-199 mg/dl, or fasting blood glucose 110-125 mg/dl), and diabetes (casual blood glucose ≥200 mg/dl, fasting blood glucose ≥126 mg/dl, or anti-diabetic drug use). Low normal, middle normal, and high normal were defined according to tertiles of casual or fasting normal blood glucose levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for pancreatic cancer mortality were estimated stratifying casual and fasting blood glucose by cohort-stratified Cox proportional hazards regression analysis, with low normal (casual blood glucose <94 mg/dl, or fasting blood glucose <90 mg/dl) as a reference.

RESULTS

Fasting blood glucose showed a dose-response relationship with pancreatic cancer mortality (p for trend = 0.005). After adjusting for covariates, HRs (95% CIs) were 2.83 (1.18-6.76) for prediabetes and 3.96 (1.56-10.08) for diabetes. However, there were no significant associations with casual blood glucose. These tendencies were observed after the exclusion of participants who were censored for the first 5 years of follow-up.

CONCLUSIONS

Fasting blood glucose is a better predictor of pancreatic cancer death than casual blood glucose.

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  • Authors+Show Affiliations

    ,

    Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8573, Japan. m-nagai@med.tohoku.ac.jp. Graduate School of Medicine, Tohoku University, Sendai, Japan. m-nagai@med.tohoku.ac.jp.

    ,

    Department of Medical Statistics, Toho University School of Medicine, Tokyo, Japan.

    ,

    Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

    ,

    Departments of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

    ,

    Department of Clinical Studies, Radiation Effects Research Foundation, Hiroshima, Japan.

    ,

    Department of Public Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

    ,

    Center for Supercentenarian Medical Research, Keio University School of Medicine, Tokyo, Japan.

    ,

    Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan. Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Public Health, Shiga University of Medical Science, Otsu, Japan. Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.

    ,

    Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan.

    Source

    Cancer causes & control : CCC 28:6 2017 Jun pg 625-633

    MeSH

    Adult
    Aged
    Blood Glucose
    Diabetes Mellitus
    Fasting
    Female
    Humans
    Japan
    Male
    Middle Aged
    Pancreatic Neoplasms
    Predictive Value of Tests
    Risk Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    28352981

    Citation

    Nagai, Masato, et al. "Fasting but Not Casual Blood Glucose Is Associated With Pancreatic Cancer Mortality in Japanese: EPOCH-JAPAN." Cancer Causes & Control : CCC, vol. 28, no. 6, 2017, pp. 625-633.
    Nagai M, Murakami Y, Tamakoshi A, et al. Fasting but not casual blood glucose is associated with pancreatic cancer mortality in Japanese: EPOCH-JAPAN. Cancer Causes Control. 2017;28(6):625-633.
    Nagai, M., Murakami, Y., Tamakoshi, A., Kiyohara, Y., Yamada, M., Ukawa, S., ... Okamura, T. (2017). Fasting but not casual blood glucose is associated with pancreatic cancer mortality in Japanese: EPOCH-JAPAN. Cancer Causes & Control : CCC, 28(6), pp. 625-633. doi:10.1007/s10552-017-0884-0.
    Nagai M, et al. Fasting but Not Casual Blood Glucose Is Associated With Pancreatic Cancer Mortality in Japanese: EPOCH-JAPAN. Cancer Causes Control. 2017;28(6):625-633. PubMed PMID: 28352981.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fasting but not casual blood glucose is associated with pancreatic cancer mortality in Japanese: EPOCH-JAPAN. AU - Nagai,Masato, AU - Murakami,Yoshitaka, AU - Tamakoshi,Akiko, AU - Kiyohara,Yutaka, AU - Yamada,Michiko, AU - Ukawa,Shigekazu, AU - Hirata,Takumi, AU - Tanaka,Sachiko, AU - Miura,Katsuyuki, AU - Ueshima,Hirotsugu, AU - Okamura,Tomonori, AU - ,, Y1 - 2017/03/28/ PY - 2016/09/01/received PY - 2017/03/11/accepted PY - 2017/3/30/pubmed PY - 2017/6/9/medline PY - 2017/3/30/entrez KW - Blood glucose KW - EPOCH-JAPAN KW - Japanese KW - Meta-analysis KW - Pancreatic cancer SP - 625 EP - 633 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 28 IS - 6 N2 - PURPOSE: The dose-response relationship between fasting blood glucose levels and risk of pancreatic cancer has been investigated, but the association between casual blood glucose levels and pancreatic cancer death has not been examined. We examined the association between casual and fasting blood glucose levels and death due to pancreatic cancer in Japanese. METHODS: We performed a pooled analysis of the individual Japanese including 46,387 participants aged 40-79 years from ten cohorts. Participants were classified into five groups: low normal, middle normal, high normal, prediabetes (casual blood glucose 140-199 mg/dl, or fasting blood glucose 110-125 mg/dl), and diabetes (casual blood glucose ≥200 mg/dl, fasting blood glucose ≥126 mg/dl, or anti-diabetic drug use). Low normal, middle normal, and high normal were defined according to tertiles of casual or fasting normal blood glucose levels. Hazard ratios (HRs) and 95% confidence intervals (CIs) for pancreatic cancer mortality were estimated stratifying casual and fasting blood glucose by cohort-stratified Cox proportional hazards regression analysis, with low normal (casual blood glucose <94 mg/dl, or fasting blood glucose <90 mg/dl) as a reference. RESULTS: Fasting blood glucose showed a dose-response relationship with pancreatic cancer mortality (p for trend = 0.005). After adjusting for covariates, HRs (95% CIs) were 2.83 (1.18-6.76) for prediabetes and 3.96 (1.56-10.08) for diabetes. However, there were no significant associations with casual blood glucose. These tendencies were observed after the exclusion of participants who were censored for the first 5 years of follow-up. CONCLUSIONS: Fasting blood glucose is a better predictor of pancreatic cancer death than casual blood glucose. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/28352981/Fasting_but_not_casual_blood_glucose_is_associated_with_pancreatic_cancer_mortality_in_Japanese:_EPOCH_JAPAN_ L2 - https://doi.org/10.1007/s10552-017-0884-0 DB - PRIME DP - Unbound Medicine ER -