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Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis.
Nutrients 2017; 9(4)N

Abstract

Abstract: Evidence suggests that reduced intake of fruit and vegetables may play a critical role in the development of asthma and allergies. The present review aimed to summarize the evidence for the association between fruit and vegetable intake, risk of asthma/wheeze and immune responses. Databases including PubMed, Cochrane, CINAHL and EMBASE were searched up to June 2016. Studies that investigated the effects of fruit and vegetable intake on risk of asthma/wheeze and immune responses were considered eligible (n = 58). Studies used cross-sectional (n = 30), cohort (n = 13), case-control (n = 8) and experimental (n = 7) designs. Most of the studies (n = 30) reported beneficial associations of fruit and vegetable consumption with risk of asthma and/or respiratory function, while eight studies found no significant relationship. Some studies (n = 20) reported mixed results, as they found a negative association between fruit only or vegetable only, and asthma. In addition, the meta-analyses in both adults and children showed inverse associations between fruit intake and risk of prevalent wheeze and asthma severity (p < 0.05). Likewise, vegetable intake was negatively associated with risk of prevalent asthma (p < 0.05). Seven studies examined immune responses in relation to fruit and vegetable intake in asthma, with n = 6 showing a protective effect against either systemic or airway inflammation. Fruit and vegetable consumption appears to be protective against asthma.

Authors+Show Affiliations

School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan NSW 2308, Australia. b.hosseini.bh@gmail.com. Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle NSW 2308, Australia. b.hosseini.bh@gmail.com.School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan NSW 2308, Australia. bronwyn.berthon@newcastle.edu.au. Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle NSW 2308, Australia. bronwyn.berthon@newcastle.edu.au.Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle NSW 2308, Australia. Peter.Wark@hnehealth.nsw.gov.au.School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan NSW 2308, Australia. lisa.wood@newcastle.edu.au. Centre for Healthy Lungs, Hunter Medical Research Institute, Newcastle NSW 2308, Australia. lisa.wood@newcastle.edu.au.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28353635

Citation

Hosseini, Banafshe, et al. "Effects of Fruit and Vegetable Consumption On Risk of Asthma, Wheezing and Immune Responses: a Systematic Review and Meta-Analysis." Nutrients, vol. 9, no. 4, 2017.
Hosseini B, Berthon BS, Wark P, et al. Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis. Nutrients. 2017;9(4).
Hosseini, B., Berthon, B. S., Wark, P., & Wood, L. G. (2017). Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis. Nutrients, 9(4), doi:10.3390/nu9040341.
Hosseini B, et al. Effects of Fruit and Vegetable Consumption On Risk of Asthma, Wheezing and Immune Responses: a Systematic Review and Meta-Analysis. Nutrients. 2017 Mar 29;9(4) PubMed PMID: 28353635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Fruit and Vegetable Consumption on Risk of Asthma, Wheezing and Immune Responses: A Systematic Review and Meta-Analysis. AU - Hosseini,Banafshe, AU - Berthon,Bronwyn S, AU - Wark,Peter, AU - Wood,Lisa G, Y1 - 2017/03/29/ PY - 2016/12/08/received PY - 2017/03/09/revised PY - 2017/03/24/accepted PY - 2017/3/30/entrez PY - 2017/3/30/pubmed PY - 2017/9/2/medline KW - antioxidant KW - asthma KW - fruit KW - immune response KW - vegetable KW - wheezing JF - Nutrients JO - Nutrients VL - 9 IS - 4 N2 - Abstract: Evidence suggests that reduced intake of fruit and vegetables may play a critical role in the development of asthma and allergies. The present review aimed to summarize the evidence for the association between fruit and vegetable intake, risk of asthma/wheeze and immune responses. Databases including PubMed, Cochrane, CINAHL and EMBASE were searched up to June 2016. Studies that investigated the effects of fruit and vegetable intake on risk of asthma/wheeze and immune responses were considered eligible (n = 58). Studies used cross-sectional (n = 30), cohort (n = 13), case-control (n = 8) and experimental (n = 7) designs. Most of the studies (n = 30) reported beneficial associations of fruit and vegetable consumption with risk of asthma and/or respiratory function, while eight studies found no significant relationship. Some studies (n = 20) reported mixed results, as they found a negative association between fruit only or vegetable only, and asthma. In addition, the meta-analyses in both adults and children showed inverse associations between fruit intake and risk of prevalent wheeze and asthma severity (p < 0.05). Likewise, vegetable intake was negatively associated with risk of prevalent asthma (p < 0.05). Seven studies examined immune responses in relation to fruit and vegetable intake in asthma, with n = 6 showing a protective effect against either systemic or airway inflammation. Fruit and vegetable consumption appears to be protective against asthma. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/28353635/Effects_of_Fruit_and_Vegetable_Consumption_on_Risk_of_Asthma_Wheezing_and_Immune_Responses:_A_Systematic_Review_and_Meta_Analysis_ L2 - http://www.mdpi.com/resolver?pii=nu9040341 DB - PRIME DP - Unbound Medicine ER -