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Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma.
Clinics (Sao Paulo). 2017 Mar; 72(3):150-153.C

Abstract

OBJECTIVE:

Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy.

METHOD:

The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively.

RESULTS:

The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively).

CONCLUSION:

These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy.

Authors+Show Affiliations

Lokman Hekim Hospital, General Surgery, Van, Turkey.Yuzuncu Yil University, School of Medicine, Department of Gastroenterology, Van, Turkey.Bezmialem Vakif University, School of Medicine, Microbiology, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28355360

Citation

Poyrazoglu, Omer Bilgehan, et al. "Helicobacter Pylory Infection in Patients With Esophageal Squamous Cell Carcinoma." Clinics (Sao Paulo, Brazil), vol. 72, no. 3, 2017, pp. 150-153.
Poyrazoglu OB, Dulger AC, Gultepe BS. Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma. Clinics (Sao Paulo). 2017;72(3):150-153.
Poyrazoglu, O. B., Dulger, A. C., & Gultepe, B. S. (2017). Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma. Clinics (Sao Paulo, Brazil), 72(3), 150-153. https://doi.org/10.6061/clinics/2017(03)04
Poyrazoglu OB, Dulger AC, Gultepe BS. Helicobacter Pylory Infection in Patients With Esophageal Squamous Cell Carcinoma. Clinics (Sao Paulo). 2017;72(3):150-153. PubMed PMID: 28355360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter Pylory infection in patients with esophageal squamous cell carcinoma. AU - Poyrazoglu,Omer Bilgehan, AU - Dulger,Ahmet Cumhur, AU - Gultepe,Bilge Sumbul, PY - 2016/07/12/received PY - 2016/12/19/accepted PY - 2017/3/30/entrez PY - 2017/3/30/pubmed PY - 2017/9/7/medline SP - 150 EP - 153 JF - Clinics (Sao Paulo, Brazil) JO - Clinics (Sao Paulo) VL - 72 IS - 3 N2 - OBJECTIVE:: Esophageal squamous cell carcinoma is one of the most common esophageal diseases in the developing world, but the relationship between esophageal squamous cell carcinoma and Helicobacter pylori infection remains a neglected topic. The primary objective of this study was to determine the association between Helicobacter pylori infection and esophageal squamous cell carcinoma. A second purpose was to determine the incidence and factors associated with Helicobacter pylori infection following esophagectomy. METHOD:: The microorganism was identified by testing the gastric biopsy materials from 95 esophageal squamous cell carcinoma patients (66 females; 39 were esophagectomized) for urease activity in a medium containing urea and a power of hydrogen detection reagent and comparing the results with those from a healthy population. Differences in patient characteristics were assessed with chi-square tests and t-tests for categorical and continuous factors, respectively. RESULTS:: The patients with esophageal squamous cell carcinoma had a significantly lower prevalence of Helicobacter pylori compared with the healthy population (p<0.001). The naive and esophagectomized patients, in contrast, showed no significant differences in Helicobacter pylori infection (p>0.005). Patients with esophageal squamous cell carcinoma showed a significant association between leukocytosis and hypoglobulinemia and the presence of Helicobacter pylori infection (p=0.023 and p=0.045, respectively). CONCLUSION:: These results suggest that Helicobacter pylori is not an etiological factor in patients with esophageal squamous cell carcinoma. We found a statistically significant negative correlation between esophageal squamous cell cancer and Helicobacter pylori infection. These findings may guide new strategies for esophageal squamous cell carcinoma therapy. SN - 1980-5322 UR - https://www.unboundmedicine.com/medline/citation/28355360/Helicobacter_Pylory_infection_in_patients_with_esophageal_squamous_cell_carcinoma_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&amp;pid=S1807-59322017000300150&amp;lng=en&amp;nrm=iso&amp;tlng=en DB - PRIME DP - Unbound Medicine ER -