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Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats.
Environ Sci Pollut Res Int. 2017 May; 24(13):12372-12383.ES

Abstract

Our objective was to explore the protective effect of artichoke leaf extract (ALE) against cadmium (Cd) toxicity-induced oxidative organ damage in rats. Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl2, 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks. After treatment with Cd, the liver and kidney malondialdehyde (MDA) increased significantly compared with the control rats. The sera interleukin (IL)-1β, tumor necrosis factor (TNF-α), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. The reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) decreased in the liver and kidney in Cd-exposed group. In combination treatment, Cd and ALE significantly improved immune response, an antioxidant system, and hepatorenal function with a significant decline in MDA. In conclusion, ALE ameliorates the immunosuppressive and hepatorenal oxidative injury stimulated by Cd in rats. These results suggest that artichoke has shown promising effects against adverse effects of Cd toxicity.

Authors+Show Affiliations

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. dr_elboshy@yahoo.com. Department of Clinical Pathology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt. dr_elboshy@yahoo.com.Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.Department of Immunology and Hematology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Giza, Egypt. Department of Laboratory and Blood Bank, King Abdullah Medical City, Makkah, Saudi Arabia.Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, 21955, Saudi Arabia. Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28357802

Citation

El-Boshy, Mohamed, et al. "Studies On the Protective Effect of the Artichoke (Cynara Scolymus) Leaf Extract Against Cadmium Toxicity-induced Oxidative Stress, Hepatorenal Damage, and Immunosuppressive and Hematological Disorders in Rats." Environmental Science and Pollution Research International, vol. 24, no. 13, 2017, pp. 12372-12383.
El-Boshy M, Ashshi A, Gaith M, et al. Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int. 2017;24(13):12372-12383.
El-Boshy, M., Ashshi, A., Gaith, M., Qusty, N., Bokhary, T., AlTaweel, N., & Abdelhady, M. (2017). Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environmental Science and Pollution Research International, 24(13), 12372-12383. https://doi.org/10.1007/s11356-017-8876-x
El-Boshy M, et al. Studies On the Protective Effect of the Artichoke (Cynara Scolymus) Leaf Extract Against Cadmium Toxicity-induced Oxidative Stress, Hepatorenal Damage, and Immunosuppressive and Hematological Disorders in Rats. Environ Sci Pollut Res Int. 2017;24(13):12372-12383. PubMed PMID: 28357802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. AU - El-Boshy,Mohamed, AU - Ashshi,Ahmad, AU - Gaith,Mazen, AU - Qusty,Naeem, AU - Bokhary,Thalat, AU - AlTaweel,Nagwa, AU - Abdelhady,Mohamed, Y1 - 2017/03/29/ PY - 2016/10/30/received PY - 2017/03/20/accepted PY - 2017/3/31/pubmed PY - 2017/6/6/medline PY - 2017/3/31/entrez KW - Artichoke KW - Cadmium KW - Immunosuppressive KW - Oxidative stress KW - Rats SP - 12372 EP - 12383 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 24 IS - 13 N2 - Our objective was to explore the protective effect of artichoke leaf extract (ALE) against cadmium (Cd) toxicity-induced oxidative organ damage in rats. Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl2, 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks. After treatment with Cd, the liver and kidney malondialdehyde (MDA) increased significantly compared with the control rats. The sera interleukin (IL)-1β, tumor necrosis factor (TNF-α), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. The reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) decreased in the liver and kidney in Cd-exposed group. In combination treatment, Cd and ALE significantly improved immune response, an antioxidant system, and hepatorenal function with a significant decline in MDA. In conclusion, ALE ameliorates the immunosuppressive and hepatorenal oxidative injury stimulated by Cd in rats. These results suggest that artichoke has shown promising effects against adverse effects of Cd toxicity. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/28357802/Studies_on_the_protective_effect_of_the_artichoke__Cynara_scolymus__leaf_extract_against_cadmium_toxicity_induced_oxidative_stress_hepatorenal_damage_and_immunosuppressive_and_hematological_disorders_in_rats_ DB - PRIME DP - Unbound Medicine ER -