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Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro.
Pharmacology. 1988; 36 Suppl 1:98-103.P

Abstract

Rhein, an aglucone of a laxative-acting anthraquinone, which induces net secretion in the human jejunum and colon, does not induce net secretion under open circuit current in in vitro conditions but reduces net absorption of electrolytes and water. In the stripped rat descending colon at a concentration of 2.10(-4) mol/l, the Na+, K+-ATPase is almost completely inhibited resulting in a decreased net absorption of electrolytes and water. There are no changes of the diffusional resistance of the paracellular pathway. Results point to a cellular mechanism of rhein by which absorption is inhibited so that physiological cellular secretion dominates. This does not rule out an additional activation of cellular secretion but net secretion can be explained solely by inhibition of absorption without the assumption of any additional secretory mechanism.

Authors+Show Affiliations

First Medical Clinic, University of Mainz, FRG.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2835785

Citation

Wanitschke, R, and U Karbach. "Influence of Rhein On Rat Colonic Na+,K+-ATPase and Permeability in Vitro." Pharmacology, vol. 36 Suppl 1, 1988, pp. 98-103.
Wanitschke R, Karbach U. Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro. Pharmacology. 1988;36 Suppl 1:98-103.
Wanitschke, R., & Karbach, U. (1988). Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro. Pharmacology, 36 Suppl 1, 98-103.
Wanitschke R, Karbach U. Influence of Rhein On Rat Colonic Na+,K+-ATPase and Permeability in Vitro. Pharmacology. 1988;36 Suppl 1:98-103. PubMed PMID: 2835785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of rhein on rat colonic Na+,K+-ATPase and permeability in vitro. AU - Wanitschke,R, AU - Karbach,U, PY - 1988/1/1/pubmed PY - 1988/1/1/medline PY - 1988/1/1/entrez SP - 98 EP - 103 JF - Pharmacology JO - Pharmacology VL - 36 Suppl 1 N2 - Rhein, an aglucone of a laxative-acting anthraquinone, which induces net secretion in the human jejunum and colon, does not induce net secretion under open circuit current in in vitro conditions but reduces net absorption of electrolytes and water. In the stripped rat descending colon at a concentration of 2.10(-4) mol/l, the Na+, K+-ATPase is almost completely inhibited resulting in a decreased net absorption of electrolytes and water. There are no changes of the diffusional resistance of the paracellular pathway. Results point to a cellular mechanism of rhein by which absorption is inhibited so that physiological cellular secretion dominates. This does not rule out an additional activation of cellular secretion but net secretion can be explained solely by inhibition of absorption without the assumption of any additional secretory mechanism. SN - 0031-7012 UR - https://www.unboundmedicine.com/medline/citation/2835785/Influence_of_rhein_on_rat_colonic_Na+K+_ATPase_and_permeability_in_vitro_ L2 - https://www.karger.com?DOI=10.1159/000138427 DB - PRIME DP - Unbound Medicine ER -