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Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis.
BMC Psychiatry 2017; 17(1):120BP

Abstract

BACKGROUND

Reports of frequent manifestation of allergic diseases in children with attention deficit hyperactivity disorder (ADHD) have been the subject of mounting clinical interest. However, evidence supporting the association between ADHD and allergies is inconsistent and has yet to be systematically reviewed. The objective of this study was to compile and assess available studies on the association between ADHD and allergic diseases in children.

METHODS

A comprehensive search using MEDLINE, EMBASE, the Cochrane library, and CINAHL databases was completed in 23 November 2015. The inclusion criteria for studies were that the research assessed allergic diseases in children, 18 years of age and younger, with a diagnosis of ADHD and that a distinct comparison group was incorporated. Any comparative studies, encompassing both randomized controlled trials and observational studies, were considered for inclusion. Two review authors independently assessed the quality of the selected studies by the use of validated assessment tools, performed data extraction and conducted meta-analysis according to Cochrane Collaboration guidelines.

RESULTS

Five eligible studies were included in this systematic review. Of these studies, three were case-control and two were cross sectional studies. A majority of information from the five studies was classified as having low or unclear risk of bias. The meta-analysis showed an association between children with ADHD and asthma compared with the control groups (OR: 1.80, 95% CI: 1.57 - 2.07; five studies, low quality of evidence), but did not indicate an association between food allergy and ADHD (OR: 1.13, 95% CI: 0.88 - 1.47; three studies very low quality of evidence). The odds of experiencing allergic rhinitis, atopic dermatitis, and allergic conjunctivitis were slightly higher in children with ADHD compared with control groups, though a substantial statistical heterogeneity was notable in the overall effect estimates.

CONCLUSIONS

The findings from this review and meta-analysis show that children with ADHD are more likely to have asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis than their counterparts. Interventions including strategies for managing allergies in children with ADHD would be beneficial.

Authors+Show Affiliations

Department of Health Policy, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.Department of Health Policy, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. ota@slcn.ac.jp. Global Health Nursing, Graduate School of Nursing Science, St. Luke's International University, 10-1 Akashicho, Chuo-ku, Tokyo, 104-0044, Japan. ota@slcn.ac.jp.Department of Health Policy, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. Graduate School of Human Sciences, Osaka University, 1-1 Yamadaoka Suita, Osaka Prefecture, 565-0871, Japan.Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.Department of Family Nursing, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8654, Japan.Department of Psychosocial Medicine, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.Department of Medical Specialties, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.Department of Health Policy, National Center for Child Health and Development, 10-1-2 Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

28359274

Citation

Miyazaki, Celine, et al. "Allergic Diseases in Children With Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-analysis." BMC Psychiatry, vol. 17, no. 1, 2017, p. 120.
Miyazaki C, Koyama M, Ota E, et al. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(1):120.
Miyazaki, C., Koyama, M., Ota, E., Swa, T., Mlunde, L. B., Amiya, R. M., ... Mori, R. (2017). Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry, 17(1), p. 120. doi:10.1186/s12888-017-1281-7.
Miyazaki C, et al. Allergic Diseases in Children With Attention Deficit Hyperactivity Disorder: a Systematic Review and Meta-analysis. BMC Psychiatry. 2017 03 31;17(1):120. PubMed PMID: 28359274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. AU - Miyazaki,Celine, AU - Koyama,Momoko, AU - Ota,Erika, AU - Swa,Toshiyuki, AU - Mlunde,Linda B, AU - Amiya,Rachel M, AU - Tachibana,Yoshiyuki, AU - Yamamoto-Hanada,Kiwako, AU - Mori,Rintaro, Y1 - 2017/03/31/ PY - 2016/06/03/received PY - 2017/03/23/accepted PY - 2017/4/1/entrez PY - 2017/4/1/pubmed PY - 2017/7/27/medline KW - Allergic conjunctivitis, Allergic disease, Allergic rhinitis, Asthma, Atopic dermatitis, Attention deficit hyper disorder, Coexisting condition, Food allergy, Meta-analysis SP - 120 EP - 120 JF - BMC psychiatry JO - BMC Psychiatry VL - 17 IS - 1 N2 - BACKGROUND: Reports of frequent manifestation of allergic diseases in children with attention deficit hyperactivity disorder (ADHD) have been the subject of mounting clinical interest. However, evidence supporting the association between ADHD and allergies is inconsistent and has yet to be systematically reviewed. The objective of this study was to compile and assess available studies on the association between ADHD and allergic diseases in children. METHODS: A comprehensive search using MEDLINE, EMBASE, the Cochrane library, and CINAHL databases was completed in 23 November 2015. The inclusion criteria for studies were that the research assessed allergic diseases in children, 18 years of age and younger, with a diagnosis of ADHD and that a distinct comparison group was incorporated. Any comparative studies, encompassing both randomized controlled trials and observational studies, were considered for inclusion. Two review authors independently assessed the quality of the selected studies by the use of validated assessment tools, performed data extraction and conducted meta-analysis according to Cochrane Collaboration guidelines. RESULTS: Five eligible studies were included in this systematic review. Of these studies, three were case-control and two were cross sectional studies. A majority of information from the five studies was classified as having low or unclear risk of bias. The meta-analysis showed an association between children with ADHD and asthma compared with the control groups (OR: 1.80, 95% CI: 1.57 - 2.07; five studies, low quality of evidence), but did not indicate an association between food allergy and ADHD (OR: 1.13, 95% CI: 0.88 - 1.47; three studies very low quality of evidence). The odds of experiencing allergic rhinitis, atopic dermatitis, and allergic conjunctivitis were slightly higher in children with ADHD compared with control groups, though a substantial statistical heterogeneity was notable in the overall effect estimates. CONCLUSIONS: The findings from this review and meta-analysis show that children with ADHD are more likely to have asthma, allergic rhinitis, atopic dermatitis, and allergic conjunctivitis than their counterparts. Interventions including strategies for managing allergies in children with ADHD would be beneficial. SN - 1471-244X UR - https://www.unboundmedicine.com/medline/citation/28359274/Allergic_diseases_in_children_with_attention_deficit_hyperactivity_disorder:_a_systematic_review_and_meta_analysis_ L2 - https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-017-1281-7 DB - PRIME DP - Unbound Medicine ER -