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Antimicrobial sesquiterpene lactones from Artemisia sieberi.
J Asian Nat Prod Res. 2017 Nov; 19(11):1093-1101.JA

Abstract

Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3'-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities.

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Authors+Show Affiliations

Mohamed TA
a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
Hegazy MF
a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt.
Abd El Aty AA
b Chemistry of Natural and Microbial Products Department , National Research Centre , Giza 12622 , Egypt.
Ghabbour HA
c Department of Pharmaceutical Chemistry , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia. d Faculty of Pharmacy, Department of Medicinal Chemistry , University of Mansoura , Mansoura 35516 , Egypt.
Alsaid MS
e Pharmacognosy Department , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
Shahat AA
a Phytochemistry Department , National Research Centre , Giza 12622 , Egypt. e Pharmacognosy Department , College of Pharmacy, King Saud University , Riyadh 11451 , Saudi Arabia.
Paré PW
f Chemistry & Biochemistry Department , Texas Tech University , Lubbock , TX 79409 , USA.

MeSH

Anti-Bacterial AgentsArtemisiaAsteraceaeBacillus subtilisLactonesMicrobial Sensitivity TestsMolecular StructurePlant ExtractsSesquiterpenesStaphylococcus aureusStereoisomerism

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28361549

Citation

Mohamed, Tarik A., et al. "Antimicrobial Sesquiterpene Lactones From Artemisia Sieberi." Journal of Asian Natural Products Research, vol. 19, no. 11, 2017, pp. 1093-1101.
Mohamed TA, Hegazy MF, Abd El Aty AA, et al. Antimicrobial sesquiterpene lactones from Artemisia sieberi. J Asian Nat Prod Res. 2017;19(11):1093-1101.
Mohamed, T. A., Hegazy, M. F., Abd El Aty, A. A., Ghabbour, H. A., Alsaid, M. S., Shahat, A. A., & Paré, P. W. (2017). Antimicrobial sesquiterpene lactones from Artemisia sieberi. Journal of Asian Natural Products Research, 19(11), 1093-1101. https://doi.org/10.1080/10286020.2017.1302939
Mohamed TA, et al. Antimicrobial Sesquiterpene Lactones From Artemisia Sieberi. J Asian Nat Prod Res. 2017;19(11):1093-1101. PubMed PMID: 28361549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimicrobial sesquiterpene lactones from Artemisia sieberi. AU - Mohamed,Tarik A, AU - Hegazy,Mohamed-Elamir F, AU - Abd El Aty,Abeer A, AU - Ghabbour,Hazem A, AU - Alsaid,Mansour S, AU - Shahat,Abdelaaty A, AU - Paré,Paul W, Y1 - 2017/03/31/ PY - 2017/4/1/pubmed PY - 2017/12/5/medline PY - 2017/4/1/entrez KW - Artemisia sieberi KW - Asteraceae KW - Sesquiterpenes KW - X-rays analysis KW - antimicrobial activity SP - 1093 EP - 1101 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 19 IS - 11 N2 - Two new sesquiterpene lactones 3R, 8R-dihydroxygermacr-4(15),9(10)-dien-6S,7S,11RH,12,6-olide (1) and 1R, 8S-dihydroxy-11R,13-dihydrobalchanin(2), together with two known compounds 11-epiartapshin (3) and 3'-hydroxygenkwanin (4), were isolated from Artemisia sieberi. Their structures were elucidated by 1D, 2D NMR, MS, and X-ray diffraction. Compound 4 inhibited Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus with Minimal inhibitory concentration values of 50 and 25 μg/disk, respectively. All the isolated compounds exhibited moderate antifungal activities. SN - 1477-2213 UR - https://www.unboundmedicine.com/medline/citation/28361549/Antimicrobial_sesquiterpene_lactones_from_Artemisia_sieberi_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020.2017.1302939 DB - PRIME DP - Unbound Medicine ER -