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Red blood cells galactose-1-P-urydil transferase in senile and presenile cataracts.

Abstract

There are conflicting reports in the literature regarding the role of partial deficiency of "galactosemic" enzymes (galactose-1-P-urydil transferase and galactokinase) in the development of infantile and presenile cataract. The AA. have investigated the levels of Red Blood Cell Galactose-1-P-urydil transferase in 39 cataractous patients and in 22 age matched controls. A weak correlation between the enzymatic activity deficiency and the presenile cataract has been identified. The results suggest that a chronic impairment of galactose metabolism may be a contributory risk factor in the pathogenesis of presenile cataracts; however, further investigations are required to assess the actual significance of the findings of the present paper.

Authors+Show Affiliations

Eye Clinic, 1st School of Medicine, University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2836694

Citation

Auricchio, G, et al. "Red Blood Cells galactose-1-P-urydil Transferase in Senile and Presenile Cataracts." Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985), vol. 8, no. 4, 1985, pp. 160-1.
Auricchio G, Rinaldi E, Simonelli F, et al. Red blood cells galactose-1-P-urydil transferase in senile and presenile cataracts. Metab Pediatr Syst Ophthalmol (1985). 1985;8(4):160-1.
Auricchio, G., Rinaldi, E., Simonelli, F., & De Rosa, G. (1985). Red blood cells galactose-1-P-urydil transferase in senile and presenile cataracts. Metabolic, Pediatric, and Systemic Ophthalmology (New York, N.Y. : 1985), 8(4), pp. 160-1.
Auricchio G, et al. Red Blood Cells galactose-1-P-urydil Transferase in Senile and Presenile Cataracts. Metab Pediatr Syst Ophthalmol (1985). 1985;8(4):160-1. PubMed PMID: 2836694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red blood cells galactose-1-P-urydil transferase in senile and presenile cataracts. AU - Auricchio,G, AU - Rinaldi,E, AU - Simonelli,F, AU - De Rosa,G, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 160 EP - 1 JF - Metabolic, pediatric, and systemic ophthalmology (New York, N.Y. : 1985) JO - Metab Pediatr Syst Ophthalmol (1985) VL - 8 IS - 4 N2 - There are conflicting reports in the literature regarding the role of partial deficiency of "galactosemic" enzymes (galactose-1-P-urydil transferase and galactokinase) in the development of infantile and presenile cataract. The AA. have investigated the levels of Red Blood Cell Galactose-1-P-urydil transferase in 39 cataractous patients and in 22 age matched controls. A weak correlation between the enzymatic activity deficiency and the presenile cataract has been identified. The results suggest that a chronic impairment of galactose metabolism may be a contributory risk factor in the pathogenesis of presenile cataracts; however, further investigations are required to assess the actual significance of the findings of the present paper. SN - 0882-889X UR - https://www.unboundmedicine.com/medline/citation/2836694/Red_blood_cells_galactose_1_P_urydil_transferase_in_senile_and_presenile_cataracts_ L2 - http://www.diseaseinfosearch.org/result/1165 DB - PRIME DP - Unbound Medicine ER -