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Protein-coding genes in B chromosomes of the grasshopper Eyprepocnemis plorans.
Sci Rep. 2017 04 03; 7:45200.SR

Abstract

For many years, parasitic B chromosomes have been considered genetically inert elements. Here we show the presence of ten protein-coding genes in the B chromosome of the grasshopper Eyprepocnemis plorans. Four of these genes (CIP2A, GTPB6, KIF20A, and MTG1) were complete in the B chromosome whereas the six remaining (CKAP2, CAP-G, HYI, MYCB2, SLIT and TOP2A) were truncated. Five of these genes (CIP2A, CKAP2, CAP-G, KIF20A, and MYCB2) were significantly up-regulated in B-carrying individuals, as expected if they were actively transcribed from the B chromosome. This conclusion is supported by three truncated genes (CKAP2, CAP-G and MYCB2) which showed up-regulation only in the regions being present in the B chromosome. Our results indicate that B chromosomes are not so silenced as was hitherto believed. Interestingly, the five active genes in the B chromosome code for functions related with cell division, which is the main arena where B chromosome destiny is played. This suggests that B chromosome evolutionary success can lie on its gene content.

Authors+Show Affiliations

Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.Leibniz Institute for Plant Genetics and Crop Plant Research (IPK), D-06466 Gatersleben, Germany. Department of Bioanalytics, Coburg University of Applied Sciences and Arts, Coburg, Germany.Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.Leibniz Institute for Plant Genetics and Crop Plant Research (IPK), D-06466 Gatersleben, Germany. Global Institute for Food Security, 110 Gymnasium Place, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 4J8, Canada.Departamento de Genética, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

28367986

Citation

Navarro-Domínguez, Beatriz, et al. "Protein-coding Genes in B Chromosomes of the Grasshopper Eyprepocnemis Plorans." Scientific Reports, vol. 7, 2017, p. 45200.
Navarro-Domínguez B, Ruiz-Ruano FJ, Cabrero J, et al. Protein-coding genes in B chromosomes of the grasshopper Eyprepocnemis plorans. Sci Rep. 2017;7:45200.
Navarro-Domínguez, B., Ruiz-Ruano, F. J., Cabrero, J., Corral, J. M., López-León, M. D., Sharbel, T. F., & Camacho, J. P. (2017). Protein-coding genes in B chromosomes of the grasshopper Eyprepocnemis plorans. Scientific Reports, 7, 45200. https://doi.org/10.1038/srep45200
Navarro-Domínguez B, et al. Protein-coding Genes in B Chromosomes of the Grasshopper Eyprepocnemis Plorans. Sci Rep. 2017 04 3;7:45200. PubMed PMID: 28367986.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein-coding genes in B chromosomes of the grasshopper Eyprepocnemis plorans. AU - Navarro-Domínguez,Beatriz, AU - Ruiz-Ruano,Francisco J, AU - Cabrero,Josefa, AU - Corral,José María, AU - López-León,María Dolores, AU - Sharbel,Timothy F, AU - Camacho,Juan Pedro M, Y1 - 2017/04/03/ PY - 2016/09/06/received PY - 2017/02/22/accepted PY - 2017/4/4/entrez PY - 2017/4/4/pubmed PY - 2018/11/9/medline SP - 45200 EP - 45200 JF - Scientific reports JO - Sci Rep VL - 7 N2 - For many years, parasitic B chromosomes have been considered genetically inert elements. Here we show the presence of ten protein-coding genes in the B chromosome of the grasshopper Eyprepocnemis plorans. Four of these genes (CIP2A, GTPB6, KIF20A, and MTG1) were complete in the B chromosome whereas the six remaining (CKAP2, CAP-G, HYI, MYCB2, SLIT and TOP2A) were truncated. Five of these genes (CIP2A, CKAP2, CAP-G, KIF20A, and MYCB2) were significantly up-regulated in B-carrying individuals, as expected if they were actively transcribed from the B chromosome. This conclusion is supported by three truncated genes (CKAP2, CAP-G and MYCB2) which showed up-regulation only in the regions being present in the B chromosome. Our results indicate that B chromosomes are not so silenced as was hitherto believed. Interestingly, the five active genes in the B chromosome code for functions related with cell division, which is the main arena where B chromosome destiny is played. This suggests that B chromosome evolutionary success can lie on its gene content. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/28367986/Protein_coding_genes_in_B_chromosomes_of_the_grasshopper_Eyprepocnemis_plorans_ L2 - https://doi.org/10.1038/srep45200 DB - PRIME DP - Unbound Medicine ER -