TY - JOUR T1 - Older Men With Anemia Have Increased Fracture Risk Independent of Bone Mineral Density. AU - Valderrábano,Rodrigo J, AU - Lee,Jennifer, AU - Lui,Li-Yung, AU - Hoffman,Andrew R, AU - Cummings,Steven R, AU - Orwoll,Eric S, AU - Wu,Joy Y, AU - ,, PY - 2017/01/26/received PY - 2017/03/15/accepted PY - 2017/4/4/pubmed PY - 2017/10/3/medline PY - 2017/4/4/entrez SP - 2199 EP - 2206 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 102 IS - 7 N2 - Context: Extremely low hemoglobin (Hgb) values have been linked to increased fracture risk at different sites. However, careful assessment of clinically defined anemia and fracture risk is lacking. Objective: To determine whether men with anemia were at increased risk of fracture after accounting for bone mineral density (BMD) and bone loss. Design: Cross-sectional analysis (at visit 3) and prospective analysis (from baseline to visit 3) in the Osteoporotic Fractures in Men (MrOS), a multisite, longitudinal cohort study. Setting: Six communities in the United States. Participants: A total of 3632 community-dwelling men (age ≥65 years) in MrOS at baseline (2000 through 2002) who were able to walk unassisted, did not have hip replacement or fracture, and had complete blood cell counts at visit 3 (2007 through 2009). Outcomes: Adjudicated spine and nonspine fractures during a median 7.2 years of follow-up. Results: Analytic baseline characteristics associated with fractures or anemia (defined as Hgb <12 g/dL) were included in multivariable models. Anemia was associated with increased risk of any fracture [hazard ratio (HR), 1.67; 95% confidence interval (CI), 1.26 to 2.21] and nonspine fracture (HR, 1.70; 95% CI, 1.25 to 2.31). A model including change in BMD slightly attenuated the association with any (HR, 1.60; 95% CI, 1.20 to 2.13) and nonspine fractures (HR, 1.57; 95% CI, 1.14 to 2.15). Including absolute BMD did not significantly alter the anemia-fracture association. Anemia was not associated with spine fracture. Conclusions: Community-dwelling older men with anemia had a 57% to 72% increase in nonspine fracture risk independent of BMD and bone loss. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/28368469/Older_Men_With_Anemia_Have_Increased_Fracture_Risk_Independent_of_Bone_Mineral_Density_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2017-00266 DB - PRIME DP - Unbound Medicine ER -