Tags

Type your tag names separated by a space and hit enter

Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline.
J Clin Endocrinol Metab. 2017 05 01; 102(5):1413-1439.JC

Abstract

Cosponsoring Associations

The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society.

Objective

To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA).

Participants

The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer.

Evidence

This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies.

Consensus Process

One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline.

Conclusions

FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation.

Authors+Show Affiliations

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229.Boston Children's Hospital, Boston, Massachusetts 02115. Massachusetts General Hospital, Boston, Massachusetts 02114.Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.Areteio Hospital, Medical School, National and Capodistrian University of Athens, Athens, Greece 10674.Massachusetts General Hospital, Boston, Massachusetts 02114.Division of Preventive Medicine, Mayo Clinic, Rochester, Minnesota 55905.University of Colorado School of Medicine, Aurora, Colorado 80045.Center for Menopause, Hormonal Disorders, and Women's Health, Columbia University Medical Center, New York, New York 10021.

Pub Type(s)

Consensus Development Conference
Journal Article
Practice Guideline

Language

eng

PubMed ID

28368518

Citation

Gordon, Catherine M., et al. "Functional Hypothalamic Amenorrhea: an Endocrine Society Clinical Practice Guideline." The Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 5, 2017, pp. 1413-1439.
Gordon CM, Ackerman KE, Berga SL, et al. Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017;102(5):1413-1439.
Gordon, C. M., Ackerman, K. E., Berga, S. L., Kaplan, J. R., Mastorakos, G., Misra, M., Murad, M. H., Santoro, N. F., & Warren, M. P. (2017). Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabolism, 102(5), 1413-1439. https://doi.org/10.1210/jc.2017-00131
Gordon CM, et al. Functional Hypothalamic Amenorrhea: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2017 05 1;102(5):1413-1439. PubMed PMID: 28368518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. AU - Gordon,Catherine M, AU - Ackerman,Kathryn E, AU - Berga,Sarah L, AU - Kaplan,Jay R, AU - Mastorakos,George, AU - Misra,Madhusmita, AU - Murad,M Hassan, AU - Santoro,Nanette F, AU - Warren,Michelle P, PY - 2017/01/13/received PY - 2017/02/23/accepted PY - 2017/4/4/pubmed PY - 2017/9/12/medline PY - 2017/4/4/entrez SP - 1413 EP - 1439 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 102 IS - 5 N2 - Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. Conclusions: FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. SN - 1945-7197 UR - https://www.unboundmedicine.com/medline/citation/28368518/Functional_Hypothalamic_Amenorrhea:_An_Endocrine_Society_Clinical_Practice_Guideline_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2017-00131 DB - PRIME DP - Unbound Medicine ER -