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Sex differences in the effects of prenatal lead exposure on birth outcomes.
Environ Pollut. 2017 Jun; 225:193-200.EP

Abstract

Studies on the associations between prenatal lead exposure and birth outcomes have been inconsistent, and few data are available on the sex differences in these associations. We measured the cord blood lead levels of newborns in Shanghai and determined their associations with birth outcomes, which included birth weight, birth length, head circumference, and the ponderal index, in the total sample and within sex subgroups. A total of 1009 mother-infant pairs were enrolled from 10 hospitals in Shanghai between September 2008 and October 2009. The geometric mean of the cord blood lead concentrations was 4.07 μg/dl (95% CI: 3.98-4.17 μg/dl). A significant inverse association was found between cord blood lead levels and head circumference only in the male subgroup, and increasing cord blood lead levels were related to significant decreases in the ponderal index only in females. The birth weights of the male infants were positively associated with cord blood lead levels; after adjusting for the maternal intake frequency of preserved eggs, the estimated mean differences in birth weights decreased by 11.7% for each 1-unit increase in the log10-transformed cord blood lead concentration. Our findings suggest that prenatal lead exposure may have sex-specific effects on birth outcomes and that maternal dietary intake may be a potential confounder in these relationships. Further studies on this topic are highly warranted.

Authors+Show Affiliations

School of Public Health, Shanghai Jiao Tong University, Shanghai, China; Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.School of Public Health and Social Work, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yanch@shkeylab-ceh.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28371734

Citation

Wang, Ju, et al. "Sex Differences in the Effects of Prenatal Lead Exposure On Birth Outcomes." Environmental Pollution (Barking, Essex : 1987), vol. 225, 2017, pp. 193-200.
Wang J, Gao ZY, Yan J, et al. Sex differences in the effects of prenatal lead exposure on birth outcomes. Environ Pollut. 2017;225:193-200.
Wang, J., Gao, Z. Y., Yan, J., Ying, X. L., Tong, S. L., & Yan, C. H. (2017). Sex differences in the effects of prenatal lead exposure on birth outcomes. Environmental Pollution (Barking, Essex : 1987), 225, 193-200. https://doi.org/10.1016/j.envpol.2017.03.031
Wang J, et al. Sex Differences in the Effects of Prenatal Lead Exposure On Birth Outcomes. Environ Pollut. 2017;225:193-200. PubMed PMID: 28371734.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in the effects of prenatal lead exposure on birth outcomes. AU - Wang,Ju, AU - Gao,Zhen-Yan, AU - Yan,Jin, AU - Ying,Xiao-Lan, AU - Tong,Shi-Lu, AU - Yan,Chong-Huai, Y1 - 2017/04/01/ PY - 2016/12/24/received PY - 2017/03/10/revised PY - 2017/03/10/accepted PY - 2017/4/4/pubmed PY - 2017/7/29/medline PY - 2017/4/4/entrez KW - Birth outcomes KW - Lead KW - Prenatal exposure KW - Sex difference SP - 193 EP - 200 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 225 N2 - Studies on the associations between prenatal lead exposure and birth outcomes have been inconsistent, and few data are available on the sex differences in these associations. We measured the cord blood lead levels of newborns in Shanghai and determined their associations with birth outcomes, which included birth weight, birth length, head circumference, and the ponderal index, in the total sample and within sex subgroups. A total of 1009 mother-infant pairs were enrolled from 10 hospitals in Shanghai between September 2008 and October 2009. The geometric mean of the cord blood lead concentrations was 4.07 μg/dl (95% CI: 3.98-4.17 μg/dl). A significant inverse association was found between cord blood lead levels and head circumference only in the male subgroup, and increasing cord blood lead levels were related to significant decreases in the ponderal index only in females. The birth weights of the male infants were positively associated with cord blood lead levels; after adjusting for the maternal intake frequency of preserved eggs, the estimated mean differences in birth weights decreased by 11.7% for each 1-unit increase in the log10-transformed cord blood lead concentration. Our findings suggest that prenatal lead exposure may have sex-specific effects on birth outcomes and that maternal dietary intake may be a potential confounder in these relationships. Further studies on this topic are highly warranted. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/28371734/Sex_differences_in_the_effects_of_prenatal_lead_exposure_on_birth_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(16)32836-6 DB - PRIME DP - Unbound Medicine ER -