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Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma.
Anticancer Res. 2017 04; 37(4):1859-1863.AR

Abstract

AIM

To report clinical outcomes of transarterial chemoembolization (TACE) using drug-eluting beads (DEBs) loaded with doxorubicin for the treatment of unresectable intrahepatic cholangiocarcinoma (CCA).

PATIENTS AND METHODS

We treated 127 patients with doxorubicin via TACE. Inclusion criteria were: diagnosis of unresectable CCA; indication for TACE, performance status (PS) 0-2, >3 months of life expectancy, >18 years old, written consent. TACE was performed using DEBs for 109 (86%) patients and polythylene glycol drug-elutable microspheres (PEG) loaded with doxorubicin for 18 (14%) patients.

RESULTS

Tumor response of the whole sample of 127 patients was partial response (PR) in 19 (15%) patients, stable disease (SD) in 101 (80%) and progressive disease (PD) in seven (5%) 3 months after therapy, with no complete responses. There were differences between type of embolics: PR was 7% and 77%, SD was 88% and 8%, and PD was 5% and 15%, and the disease control rate was 95% and 85% in the DEB and PEG groups, respectively. Most frequent side-effects were: abdominal pain, fever, nausea, and transaminase rise.

CONCLUSION

TACE was effective and safe for CCA treatment, with a high disease control rate. The best response of PEG-TACE was PR, whereas it was SD for DEB-TACE.

Authors+Show Affiliations

Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.Oncology Unit, Agency Reunited Hospital of North Marche, Pesaro, Italy.Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.Oncology Radiodiagnostics, Oncology Institute of Veneto, Institute for the Research and Treatment of Cancer (IRCC), Padua, Italy.Diagnostics for Images Unit and Interventional Radiology, Agency Reunited Hospital of North Marche, Pesaro, Italy.Diagnostics for Images Unit and Interventional Radiology, Agency Reunited Hospital of North Marche, Pesaro, Italy.Oncology Unit, Agency Reunited Hospital of North Marche, Pesaro, Italy giammaria.fiorentini@ospedalimarchenord.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28373452

Citation

Aliberti, Camillo, et al. "Chemoembolization With Drug-eluting Microspheres Loaded With Doxorubicin for the Treatment of Cholangiocarcinoma." Anticancer Research, vol. 37, no. 4, 2017, pp. 1859-1863.
Aliberti C, Carandina R, Sarti D, et al. Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma. Anticancer Res. 2017;37(4):1859-1863.
Aliberti, C., Carandina, R., Sarti, D., Pizzirani, E., Ramondo, G., Mulazzani, L., Mattioli, G. M., & Fiorentini, G. (2017). Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma. Anticancer Research, 37(4), 1859-1863.
Aliberti C, et al. Chemoembolization With Drug-eluting Microspheres Loaded With Doxorubicin for the Treatment of Cholangiocarcinoma. Anticancer Res. 2017;37(4):1859-1863. PubMed PMID: 28373452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chemoembolization with Drug-eluting Microspheres Loaded with Doxorubicin for the Treatment of Cholangiocarcinoma. AU - Aliberti,Camillo, AU - Carandina,Riccardo, AU - Sarti,Donatella, AU - Pizzirani,Enrico, AU - Ramondo,Gaetano, AU - Mulazzani,Luca, AU - Mattioli,Gian Maria, AU - Fiorentini,Giammaria, PY - 2017/02/23/received PY - 2017/02/27/revised PY - 2017/03/02/accepted PY - 2017/4/5/entrez PY - 2017/4/5/pubmed PY - 2017/4/14/medline KW - Cholangiocarcinoma KW - chemoembolization KW - intra-arterial chemotherapy KW - safety KW - tumor response SP - 1859 EP - 1863 JF - Anticancer research JO - Anticancer Res. VL - 37 IS - 4 N2 - AIM: To report clinical outcomes of transarterial chemoembolization (TACE) using drug-eluting beads (DEBs) loaded with doxorubicin for the treatment of unresectable intrahepatic cholangiocarcinoma (CCA). PATIENTS AND METHODS: We treated 127 patients with doxorubicin via TACE. Inclusion criteria were: diagnosis of unresectable CCA; indication for TACE, performance status (PS) 0-2, >3 months of life expectancy, >18 years old, written consent. TACE was performed using DEBs for 109 (86%) patients and polythylene glycol drug-elutable microspheres (PEG) loaded with doxorubicin for 18 (14%) patients. RESULTS: Tumor response of the whole sample of 127 patients was partial response (PR) in 19 (15%) patients, stable disease (SD) in 101 (80%) and progressive disease (PD) in seven (5%) 3 months after therapy, with no complete responses. There were differences between type of embolics: PR was 7% and 77%, SD was 88% and 8%, and PD was 5% and 15%, and the disease control rate was 95% and 85% in the DEB and PEG groups, respectively. Most frequent side-effects were: abdominal pain, fever, nausea, and transaminase rise. CONCLUSION: TACE was effective and safe for CCA treatment, with a high disease control rate. The best response of PEG-TACE was PR, whereas it was SD for DEB-TACE. SN - 1791-7530 UR - https://www.unboundmedicine.com/medline/citation/28373452/Chemoembolization_with_Drug_eluting_Microspheres_Loaded_with_Doxorubicin_for_the_Treatment_of_Cholangiocarcinoma_ L2 - http://ar.iiarjournals.org/cgi/pmidlookup?view=long&pmid=28373452 DB - PRIME DP - Unbound Medicine ER -