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Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study.
BMC Urol. 2017 Apr 04; 17(1):22.BU

Abstract

BACKGROUND

In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in men surgically treated for BPE.

METHODS

Overall, 379 men were prospectively enrolled in two tertiary referral centers. Calculated prostate volume (PV) was measured with transrectal US defining the antero-posterior (AP), the cranio-caudal (CC) and the latero-lateral (LL) diameters through the ellipsoid formula, while raw PV was calculated by suprapubic US. MetS was defined according to the NCEP-ATPIII criteria.

RESULTS

One-hundred and forty men (36.9%) were affected by MetS. The number of MetS parameters (0 to 5) and the presence of MetS were correlated with the calculated PV. The number of MetS parameters were also directly related to increasing prostate diameters. At the binary logistic regression, MetS resulted associated to high (>60 cc) raw and calculated PV. Moreover, multivariate analysis suggested that AP diameter was mainly correlated with HDL cholesterol (r:-0.3103, p = 0.002) CC diameter with triglycerides (r:-0.191, p = 0.050) and LL diameter with systolic blood pressure (r:0.154, p = 0.044). However, at the binary logistic regression, only low HDL Cholesterol was the main determinant for the enlargement of all diameters and consequently of the whole PV.

CONCLUSIONS

Metabolic factors, specially dyslipidemia, could play a central role in the pathogenesis and progression of BPE/LUTS. Interventional studies are needed to evaluate the impact of early treatment of dyslipidemia on progression of LUTS/BPH.

Authors+Show Affiliations

Department of Urology, University of Florence, Careggi Hospital, Florence, Italy. maurogacci@yahoo.it.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.Department of Urology, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.Department of Clinical Physiopathology, University of Florence, Florence, Italy.Endocrinology Unit, Maggiore-Bellaria Hospital, Bologna, Italy.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.Department of Urology, Policlinico Hospital, University of Catania, Catania, Italy.Department of Clinical Physiopathology, University of Florence, Florence, Italy.Department of Urology, Policlinico Hospital, University of Catania, Catania, Italy.Department of Urology, Sant'Andrea Hospital, University "La Sapienza", Rome, Italy.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.Department of Urology, University of Florence, Careggi Hospital, Florence, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

28376747

Citation

Gacci, Mauro, et al. "Benign Prostatic Enlargement Can Be Influenced By Metabolic Profile: Results of a Multicenter Prospective Study." BMC Urology, vol. 17, no. 1, 2017, p. 22.
Gacci M, Sebastianelli A, Salvi M, et al. Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study. BMC Urol. 2017;17(1):22.
Gacci, M., Sebastianelli, A., Salvi, M., De Nunzio, C., Vignozzi, L., Corona, G., Jaeger, T., Chini, T., Russo, G. I., Maggi, M., Morgia, G., Tubaro, A., Carini, M., & Serni, S. (2017). Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study. BMC Urology, 17(1), 22. https://doi.org/10.1186/s12894-017-0211-9
Gacci M, et al. Benign Prostatic Enlargement Can Be Influenced By Metabolic Profile: Results of a Multicenter Prospective Study. BMC Urol. 2017 Apr 4;17(1):22. PubMed PMID: 28376747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benign prostatic enlargement can be influenced by metabolic profile: results of a multicenter prospective study. AU - Gacci,Mauro, AU - Sebastianelli,Arcangelo, AU - Salvi,Matteo, AU - De Nunzio,Cosimo, AU - Vignozzi,Linda, AU - Corona,Giovanni, AU - Jaeger,Tommaso, AU - Chini,Tommaso, AU - Russo,Giorgio Ivan, AU - Maggi,Mario, AU - Morgia,Giuseppe, AU - Tubaro,Andrea, AU - Carini,Marco, AU - Serni,Sergio, Y1 - 2017/04/04/ PY - 2016/02/18/received PY - 2017/03/22/accepted PY - 2017/4/6/entrez PY - 2017/4/6/pubmed PY - 2017/8/22/medline KW - Benign prostatic enlargement KW - Benign prostatic hyperplasia KW - Dyslipidemia KW - Lower urinary tract symptoms KW - Metabolic syndrome SP - 22 EP - 22 JF - BMC urology JO - BMC Urol VL - 17 IS - 1 N2 - BACKGROUND: In last years Metabolic Syndrome (MetS) has been closely associated to Benign Prostatic Enlargement (BPE) Aim of our study is to evaluate the effect of MetS and each single MetS parameter on prostate growth in men surgically treated for BPE. METHODS: Overall, 379 men were prospectively enrolled in two tertiary referral centers. Calculated prostate volume (PV) was measured with transrectal US defining the antero-posterior (AP), the cranio-caudal (CC) and the latero-lateral (LL) diameters through the ellipsoid formula, while raw PV was calculated by suprapubic US. MetS was defined according to the NCEP-ATPIII criteria. RESULTS: One-hundred and forty men (36.9%) were affected by MetS. The number of MetS parameters (0 to 5) and the presence of MetS were correlated with the calculated PV. The number of MetS parameters were also directly related to increasing prostate diameters. At the binary logistic regression, MetS resulted associated to high (>60 cc) raw and calculated PV. Moreover, multivariate analysis suggested that AP diameter was mainly correlated with HDL cholesterol (r:-0.3103, p = 0.002) CC diameter with triglycerides (r:-0.191, p = 0.050) and LL diameter with systolic blood pressure (r:0.154, p = 0.044). However, at the binary logistic regression, only low HDL Cholesterol was the main determinant for the enlargement of all diameters and consequently of the whole PV. CONCLUSIONS: Metabolic factors, specially dyslipidemia, could play a central role in the pathogenesis and progression of BPE/LUTS. Interventional studies are needed to evaluate the impact of early treatment of dyslipidemia on progression of LUTS/BPH. SN - 1471-2490 UR - https://www.unboundmedicine.com/medline/citation/28376747/Benign_prostatic_enlargement_can_be_influenced_by_metabolic_profile:_results_of_a_multicenter_prospective_study_ L2 - https://bmcurol.biomedcentral.com/articles/10.1186/s12894-017-0211-9 DB - PRIME DP - Unbound Medicine ER -