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Association between lutein intake and lung function in adults: the Rotterdam Study.
Br J Nutr. 2017 Mar; 117(5):720-730.BJ

Abstract

Lutein, a fat-soluble carotenoid with antioxidant properties, may have an effect on respiratory health. However, the evidence is inconsistent. We aimed to cross-sectionally investigate the association between lutein intake and lung function by measuring forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC% in adults (aged 45-79 years). We included 4402 participants from the Rotterdam Study, a prospective cohort study in The Netherlands. Lutein intake was assessed using a validated FFQ. Lung function was assessed using spirometry around the same time point as the dietary assessment. No independent association was found between lutein intake and FEV1 (-12·17 (95 % CI -34·21, 9·87) ml per sd increase in lutein) after adjustment for age, sex, height, cohort effect, ethnicity, education, weight, total daily energy intake, smoking status, physical activity, and intakes of fatty acids, dietary fibre, alcohol, β-carotene, β-crypotoxanthin, lycopene and zeaxanthin. There was also no association between lutein and FVC or FEV1/FVC%. However, after stratification by smoking status, lutein intake was significantly associated with lower FEV1/FVC% in current smokers (-1·69 (95 % CI -2·93, -0·45) % per sd increase of lutein) independent of other carotenoids. The present study does not support an independent association between lutein intake and lung function in adults. However, future studies should focus on the potential inverse association between high lutein intake and lung function in specific risk groups such as smokers.

Authors+Show Affiliations

1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.1Department of Epidemiology,Erasmus MC University Medical Center,3000 CA, Rotterdam,The Netherlands.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

28376947

Citation

Melo van Lent, Debora, et al. "Association Between Lutein Intake and Lung Function in Adults: the Rotterdam Study." The British Journal of Nutrition, vol. 117, no. 5, 2017, pp. 720-730.
Melo van Lent D, Leermakers ET, Hofman A, et al. Association between lutein intake and lung function in adults: the Rotterdam Study. Br J Nutr. 2017;117(5):720-730.
Melo van Lent, D., Leermakers, E. T., Hofman, A., Stricker, B. H., Brusselle, G. G., Franco, O. H., Lahousse, L., & Kiefte-de Jong, J. C. (2017). Association between lutein intake and lung function in adults: the Rotterdam Study. The British Journal of Nutrition, 117(5), 720-730. https://doi.org/10.1017/S0007114517000319
Melo van Lent D, et al. Association Between Lutein Intake and Lung Function in Adults: the Rotterdam Study. Br J Nutr. 2017;117(5):720-730. PubMed PMID: 28376947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between lutein intake and lung function in adults: the Rotterdam Study. AU - Melo van Lent,Debora, AU - Leermakers,Elisabeth T M, AU - Hofman,Albert, AU - Stricker,Bruno H, AU - Brusselle,Guy G, AU - Franco,Oscar H, AU - Lahousse,Lies, AU - Kiefte-de Jong,Jessica C, Y1 - 2017/04/05/ PY - 2017/4/6/pubmed PY - 2017/4/21/medline PY - 2017/4/6/entrez KW - COPD chronic obstructive pulmonary disease KW - FEV1 forced expiratory volume in 1 s KW - FVC forced vital capacity KW - RS-I–III Rotterdam Study cohorts I–III KW - Adults KW - Antioxidants KW - Carotenoids KW - Elderly KW - Lung function KW - Lutein SP - 720 EP - 730 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 117 IS - 5 N2 - Lutein, a fat-soluble carotenoid with antioxidant properties, may have an effect on respiratory health. However, the evidence is inconsistent. We aimed to cross-sectionally investigate the association between lutein intake and lung function by measuring forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC% in adults (aged 45-79 years). We included 4402 participants from the Rotterdam Study, a prospective cohort study in The Netherlands. Lutein intake was assessed using a validated FFQ. Lung function was assessed using spirometry around the same time point as the dietary assessment. No independent association was found between lutein intake and FEV1 (-12·17 (95 % CI -34·21, 9·87) ml per sd increase in lutein) after adjustment for age, sex, height, cohort effect, ethnicity, education, weight, total daily energy intake, smoking status, physical activity, and intakes of fatty acids, dietary fibre, alcohol, β-carotene, β-crypotoxanthin, lycopene and zeaxanthin. There was also no association between lutein and FVC or FEV1/FVC%. However, after stratification by smoking status, lutein intake was significantly associated with lower FEV1/FVC% in current smokers (-1·69 (95 % CI -2·93, -0·45) % per sd increase of lutein) independent of other carotenoids. The present study does not support an independent association between lutein intake and lung function in adults. However, future studies should focus on the potential inverse association between high lutein intake and lung function in specific risk groups such as smokers. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/28376947/Association_between_lutein_intake_and_lung_function_in_adults:_the_Rotterdam_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114517000319/type/journal_article DB - PRIME DP - Unbound Medicine ER -